Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
- Autores
- Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; Antuna Puente, Bárbara; Macias Kauffer, Luis Rodrigo; Villalobos Comparán, Marisela; Ortiz Maldonado, Jair; Yu, Neng; Lebedeva, Tatiana V.; Alosco, Sharon M.; García Rodríguez, Juan Daniel; González Torres, Carolina; Rosas Madrigal, Sandra; Ordoñez, Graciela; Guerrero Camacho, Jorge Luis; Treviño Frenk, Irene; Escamilla Tilch, Monica; García Lechuga, Maricela; Tovar Méndez, Víctor Hugo; Pacheco Ubaldo, Hanna; Acuña Alonzo, Victor; Bortolini, María Cátira; Gallo, Carla; Bedoya Berrío, Gabriel; Rothhammer, Francisco; Gonzalez-Jose, Rolando; Ruiz Linares, Andrés; Canizales Quinteros, Samuel; Yunis, Edmond; Granados, Julio; Corona, Teresa
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; México
Fil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; México
Fil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; México
Fil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; México
Fil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; México
Fil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; México
Fil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Yu, Neng. American Red Cross; Estados Unidos
Fil: Lebedeva, Tatiana V.. American Red Cross; Estados Unidos
Fil: Alosco, Sharon M.. American Red Cross; Estados Unidos
Fil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; México
Fil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; México
Fil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; México
Fil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; México
Fil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Yunis, Edmond. Dana Farber Cancer Institute; Estados Unidos
Fil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; México - Materia
-
NEUROMIELITIS OPTICA
LATINOAMERICANOS
MESTIZAJE
MEXICO - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/126000
Ver los metadatos del registro completo
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spelling |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican populationRomero Hidalgo, SandraFlores Rivera, JoséRivas Alonso, VerónicaBarquera, RodrigoVillarreal Molina, María TeresaAntuna Puente, BárbaraMacias Kauffer, Luis RodrigoVillalobos Comparán, MariselaOrtiz Maldonado, JairYu, NengLebedeva, Tatiana V.Alosco, Sharon M.García Rodríguez, Juan DanielGonzález Torres, CarolinaRosas Madrigal, SandraOrdoñez, GracielaGuerrero Camacho, Jorge LuisTreviño Frenk, IreneEscamilla Tilch, MonicaGarcía Lechuga, MaricelaTovar Méndez, Víctor HugoPacheco Ubaldo, HannaAcuña Alonzo, VictorBortolini, María CátiraGallo, CarlaBedoya Berrío, GabrielRothhammer, FranciscoGonzalez-Jose, RolandoRuiz Linares, AndrésCanizales Quinteros, SamuelYunis, EdmondGranados, JulioCorona, TeresaNEUROMIELITIS OPTICALATINOAMERICANOSMESTIZAJEMEXICOhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; MéxicoFil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; MéxicoFil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; MéxicoFil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; MéxicoFil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; MéxicoFil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; MéxicoFil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Yu, Neng. American Red Cross; Estados UnidosFil: Lebedeva, Tatiana V.. American Red Cross; Estados UnidosFil: Alosco, Sharon M.. American Red Cross; Estados UnidosFil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; MéxicoFil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; MéxicoFil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; MéxicoFil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; BrasilFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Bedoya Berrío, Gabriel. Universidad de Antioquia; ColombiaFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino UnidoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Yunis, Edmond. Dana Farber Cancer Institute; Estados UnidosFil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; MéxicoNature Research2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/126000Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; et al.; Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-69224-3info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-69224-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:21Zoai:ri.conicet.gov.ar:11336/126000instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:21.898CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
title |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
spellingShingle |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population Romero Hidalgo, Sandra NEUROMIELITIS OPTICA LATINOAMERICANOS MESTIZAJE MEXICO |
title_short |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
title_full |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
title_fullStr |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
title_full_unstemmed |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
title_sort |
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population |
dc.creator.none.fl_str_mv |
Romero Hidalgo, Sandra Flores Rivera, José Rivas Alonso, Verónica Barquera, Rodrigo Villarreal Molina, María Teresa Antuna Puente, Bárbara Macias Kauffer, Luis Rodrigo Villalobos Comparán, Marisela Ortiz Maldonado, Jair Yu, Neng Lebedeva, Tatiana V. Alosco, Sharon M. García Rodríguez, Juan Daniel González Torres, Carolina Rosas Madrigal, Sandra Ordoñez, Graciela Guerrero Camacho, Jorge Luis Treviño Frenk, Irene Escamilla Tilch, Monica García Lechuga, Maricela Tovar Méndez, Víctor Hugo Pacheco Ubaldo, Hanna Acuña Alonzo, Victor Bortolini, María Cátira Gallo, Carla Bedoya Berrío, Gabriel Rothhammer, Francisco Gonzalez-Jose, Rolando Ruiz Linares, Andrés Canizales Quinteros, Samuel Yunis, Edmond Granados, Julio Corona, Teresa |
author |
Romero Hidalgo, Sandra |
author_facet |
Romero Hidalgo, Sandra Flores Rivera, José Rivas Alonso, Verónica Barquera, Rodrigo Villarreal Molina, María Teresa Antuna Puente, Bárbara Macias Kauffer, Luis Rodrigo Villalobos Comparán, Marisela Ortiz Maldonado, Jair Yu, Neng Lebedeva, Tatiana V. Alosco, Sharon M. García Rodríguez, Juan Daniel González Torres, Carolina Rosas Madrigal, Sandra Ordoñez, Graciela Guerrero Camacho, Jorge Luis Treviño Frenk, Irene Escamilla Tilch, Monica García Lechuga, Maricela Tovar Méndez, Víctor Hugo Pacheco Ubaldo, Hanna Acuña Alonzo, Victor Bortolini, María Cátira Gallo, Carla Bedoya Berrío, Gabriel Rothhammer, Francisco Gonzalez-Jose, Rolando Ruiz Linares, Andrés Canizales Quinteros, Samuel Yunis, Edmond Granados, Julio Corona, Teresa |
author_role |
author |
author2 |
Flores Rivera, José Rivas Alonso, Verónica Barquera, Rodrigo Villarreal Molina, María Teresa Antuna Puente, Bárbara Macias Kauffer, Luis Rodrigo Villalobos Comparán, Marisela Ortiz Maldonado, Jair Yu, Neng Lebedeva, Tatiana V. Alosco, Sharon M. García Rodríguez, Juan Daniel González Torres, Carolina Rosas Madrigal, Sandra Ordoñez, Graciela Guerrero Camacho, Jorge Luis Treviño Frenk, Irene Escamilla Tilch, Monica García Lechuga, Maricela Tovar Méndez, Víctor Hugo Pacheco Ubaldo, Hanna Acuña Alonzo, Victor Bortolini, María Cátira Gallo, Carla Bedoya Berrío, Gabriel Rothhammer, Francisco Gonzalez-Jose, Rolando Ruiz Linares, Andrés Canizales Quinteros, Samuel Yunis, Edmond Granados, Julio Corona, Teresa |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
NEUROMIELITIS OPTICA LATINOAMERICANOS MESTIZAJE MEXICO |
topic |
NEUROMIELITIS OPTICA LATINOAMERICANOS MESTIZAJE MEXICO |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America. Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; México Fil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; México Fil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; México Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; México Fil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; México Fil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; México Fil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; México Fil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; México Fil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; México Fil: Yu, Neng. American Red Cross; Estados Unidos Fil: Lebedeva, Tatiana V.. American Red Cross; Estados Unidos Fil: Alosco, Sharon M.. American Red Cross; Estados Unidos Fil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; México Fil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; México Fil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; México Fil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; México Fil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; México Fil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Yunis, Edmond. Dana Farber Cancer Institute; Estados Unidos Fil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; México |
description |
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/126000 Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; et al.; Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-12 2045-2322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/126000 |
identifier_str_mv |
Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; et al.; Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-12 2045-2322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-69224-3 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-69224-3 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614456411160576 |
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13.070432 |