Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

Autores
Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; Antuna Puente, Bárbara; Macias Kauffer, Luis Rodrigo; Villalobos Comparán, Marisela; Ortiz Maldonado, Jair; Yu, Neng; Lebedeva, Tatiana V.; Alosco, Sharon M.; García Rodríguez, Juan Daniel; González Torres, Carolina; Rosas Madrigal, Sandra; Ordoñez, Graciela; Guerrero Camacho, Jorge Luis; Treviño Frenk, Irene; Escamilla Tilch, Monica; García Lechuga, Maricela; Tovar Méndez, Víctor Hugo; Pacheco Ubaldo, Hanna; Acuña Alonzo, Victor; Bortolini, María Cátira; Gallo, Carla; Bedoya Berrío, Gabriel; Rothhammer, Francisco; Gonzalez-Jose, Rolando; Ruiz Linares, Andrés; Canizales Quinteros, Samuel; Yunis, Edmond; Granados, Julio; Corona, Teresa
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; México
Fil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; México
Fil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; México
Fil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; México
Fil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; México
Fil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; México
Fil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Yu, Neng. American Red Cross; Estados Unidos
Fil: Lebedeva, Tatiana V.. American Red Cross; Estados Unidos
Fil: Alosco, Sharon M.. American Red Cross; Estados Unidos
Fil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; México
Fil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; México
Fil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; México
Fil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; México
Fil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Yunis, Edmond. Dana Farber Cancer Institute; Estados Unidos
Fil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; México
Materia
NEUROMIELITIS OPTICA
LATINOAMERICANOS
MESTIZAJE
MEXICO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/126000

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oai_identifier_str oai:ri.conicet.gov.ar:11336/126000
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican populationRomero Hidalgo, SandraFlores Rivera, JoséRivas Alonso, VerónicaBarquera, RodrigoVillarreal Molina, María TeresaAntuna Puente, BárbaraMacias Kauffer, Luis RodrigoVillalobos Comparán, MariselaOrtiz Maldonado, JairYu, NengLebedeva, Tatiana V.Alosco, Sharon M.García Rodríguez, Juan DanielGonzález Torres, CarolinaRosas Madrigal, SandraOrdoñez, GracielaGuerrero Camacho, Jorge LuisTreviño Frenk, IreneEscamilla Tilch, MonicaGarcía Lechuga, MaricelaTovar Méndez, Víctor HugoPacheco Ubaldo, HannaAcuña Alonzo, VictorBortolini, María CátiraGallo, CarlaBedoya Berrío, GabrielRothhammer, FranciscoGonzalez-Jose, RolandoRuiz Linares, AndrésCanizales Quinteros, SamuelYunis, EdmondGranados, JulioCorona, TeresaNEUROMIELITIS OPTICALATINOAMERICANOSMESTIZAJEMEXICOhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; MéxicoFil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; MéxicoFil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; MéxicoFil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; MéxicoFil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; MéxicoFil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; MéxicoFil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Yu, Neng. American Red Cross; Estados UnidosFil: Lebedeva, Tatiana V.. American Red Cross; Estados UnidosFil: Alosco, Sharon M.. American Red Cross; Estados UnidosFil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; MéxicoFil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; MéxicoFil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; MéxicoFil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; BrasilFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Bedoya Berrío, Gabriel. Universidad de Antioquia; ColombiaFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino UnidoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Yunis, Edmond. Dana Farber Cancer Institute; Estados UnidosFil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; MéxicoNature Research2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/126000Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; et al.; Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-69224-3info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-69224-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:21Zoai:ri.conicet.gov.ar:11336/126000instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:21.898CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
spellingShingle Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
Romero Hidalgo, Sandra
NEUROMIELITIS OPTICA
LATINOAMERICANOS
MESTIZAJE
MEXICO
title_short Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_full Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_fullStr Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_full_unstemmed Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_sort Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
dc.creator.none.fl_str_mv Romero Hidalgo, Sandra
Flores Rivera, José
Rivas Alonso, Verónica
Barquera, Rodrigo
Villarreal Molina, María Teresa
Antuna Puente, Bárbara
Macias Kauffer, Luis Rodrigo
Villalobos Comparán, Marisela
Ortiz Maldonado, Jair
Yu, Neng
Lebedeva, Tatiana V.
Alosco, Sharon M.
García Rodríguez, Juan Daniel
González Torres, Carolina
Rosas Madrigal, Sandra
Ordoñez, Graciela
Guerrero Camacho, Jorge Luis
Treviño Frenk, Irene
Escamilla Tilch, Monica
García Lechuga, Maricela
Tovar Méndez, Víctor Hugo
Pacheco Ubaldo, Hanna
Acuña Alonzo, Victor
Bortolini, María Cátira
Gallo, Carla
Bedoya Berrío, Gabriel
Rothhammer, Francisco
Gonzalez-Jose, Rolando
Ruiz Linares, Andrés
Canizales Quinteros, Samuel
Yunis, Edmond
Granados, Julio
Corona, Teresa
author Romero Hidalgo, Sandra
author_facet Romero Hidalgo, Sandra
Flores Rivera, José
Rivas Alonso, Verónica
Barquera, Rodrigo
Villarreal Molina, María Teresa
Antuna Puente, Bárbara
Macias Kauffer, Luis Rodrigo
Villalobos Comparán, Marisela
Ortiz Maldonado, Jair
Yu, Neng
Lebedeva, Tatiana V.
Alosco, Sharon M.
García Rodríguez, Juan Daniel
González Torres, Carolina
Rosas Madrigal, Sandra
Ordoñez, Graciela
Guerrero Camacho, Jorge Luis
Treviño Frenk, Irene
Escamilla Tilch, Monica
García Lechuga, Maricela
Tovar Méndez, Víctor Hugo
Pacheco Ubaldo, Hanna
Acuña Alonzo, Victor
Bortolini, María Cátira
Gallo, Carla
Bedoya Berrío, Gabriel
Rothhammer, Francisco
Gonzalez-Jose, Rolando
Ruiz Linares, Andrés
Canizales Quinteros, Samuel
Yunis, Edmond
Granados, Julio
Corona, Teresa
author_role author
author2 Flores Rivera, José
Rivas Alonso, Verónica
Barquera, Rodrigo
Villarreal Molina, María Teresa
Antuna Puente, Bárbara
Macias Kauffer, Luis Rodrigo
Villalobos Comparán, Marisela
Ortiz Maldonado, Jair
Yu, Neng
Lebedeva, Tatiana V.
Alosco, Sharon M.
García Rodríguez, Juan Daniel
González Torres, Carolina
Rosas Madrigal, Sandra
Ordoñez, Graciela
Guerrero Camacho, Jorge Luis
Treviño Frenk, Irene
Escamilla Tilch, Monica
García Lechuga, Maricela
Tovar Méndez, Víctor Hugo
Pacheco Ubaldo, Hanna
Acuña Alonzo, Victor
Bortolini, María Cátira
Gallo, Carla
Bedoya Berrío, Gabriel
Rothhammer, Francisco
Gonzalez-Jose, Rolando
Ruiz Linares, Andrés
Canizales Quinteros, Samuel
Yunis, Edmond
Granados, Julio
Corona, Teresa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NEUROMIELITIS OPTICA
LATINOAMERICANOS
MESTIZAJE
MEXICO
topic NEUROMIELITIS OPTICA
LATINOAMERICANOS
MESTIZAJE
MEXICO
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; México
Fil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; México
Fil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; México
Fil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; México
Fil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; México
Fil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; México
Fil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Yu, Neng. American Red Cross; Estados Unidos
Fil: Lebedeva, Tatiana V.. American Red Cross; Estados Unidos
Fil: Alosco, Sharon M.. American Red Cross; Estados Unidos
Fil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; México
Fil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; México
Fil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; México
Fil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; México
Fil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Yunis, Edmond. Dana Farber Cancer Institute; Estados Unidos
Fil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; México
Fil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; México
description Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/126000
Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; et al.; Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-12
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/126000
identifier_str_mv Romero Hidalgo, Sandra; Flores Rivera, José; Rivas Alonso, Verónica; Barquera, Rodrigo; Villarreal Molina, María Teresa; et al.; Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-12
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-69224-3
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https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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