Facial asymmetry and genetic ancestry in Latin American admixed populations

Autores
Quinto Sanchez, Mirsha Emmanuel; Adhikari, Kaustubh; Acuña Alonzo, Victor; Cintas, Celia; Silva de Cerqueira, Caio Cesar; Ramallo, Virginia; Castillo, Lucía Daniela; Farrera, Arodi; Jaramillo, Claudia; Williams Arias; Fuentes, Macarena; Everardo, Paola; de Avila, Francisco; Gomez Valdés, Jorge; Hünemeier, Tábita; Gibbon, Shara; Gallo, Carla; Poletti, Giovanni; Rosique, Javier; Bortolini, Maria Cátira; Canizales Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Ruiz Linares, Andres; Gonzalez Jose, Rolando
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise.
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Adhikari, Kaustubh. University College London; Estados Unidos
Fil: Acuña Alonzo, Victor. University College London; Estados Unidos. Instituto Nacional de Antropología E Historia; México
Fil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Castillo, Lucía Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Farrera, Arodi. Universidad Nacional Autónoma de México; México
Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia
Fil: Williams Arias. Universidad de Antioquia; Colombia
Fil: Fuentes, Macarena. Universidad de Tarapacá; Chile
Fil: Everardo, Paola. Instituto Nacional de Antropología E Historia; México
Fil: de Avila, Francisco. Instituto Nacional de Antropología E Historia; México
Fil: Gomez Valdés, Jorge. Universidad Nacional Autónoma de México; México
Fil: Hünemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gibbon, Shara. University College London; Estados Unidos
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Ruiz Linares, Andres. University College London; Estados Unidos
Fil: Gonzalez Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Materia
Facial Directional Asymmetry
Facial Fluctuating Asymmetry
Genetic Ancestry
Latin America
Geometric Morphometrics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/19966
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Facial asymmetry and genetic ancestry in Latin American admixed populationsQuinto Sanchez, Mirsha EmmanuelAdhikari, KaustubhAcuña Alonzo, VictorCintas, CeliaSilva de Cerqueira, Caio CesarRamallo, VirginiaCastillo, Lucía DanielaFarrera, ArodiJaramillo, ClaudiaWilliams AriasFuentes, MacarenaEverardo, Paolade Avila, FranciscoGomez Valdés, JorgeHünemeier, TábitaGibbon, SharaGallo, CarlaPoletti, GiovanniRosique, JavierBortolini, Maria CátiraCanizales Quinteros, SamuelRothhammer, FranciscoBedoya, GabrielRuiz Linares, AndresGonzalez Jose, RolandoFacial Directional AsymmetryFacial Fluctuating AsymmetryGenetic AncestryLatin AmericaGeometric Morphometricshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise.Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Adhikari, Kaustubh. University College London; Estados UnidosFil: Acuña Alonzo, Victor. University College London; Estados Unidos. Instituto Nacional de Antropología E Historia; MéxicoFil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Castillo, Lucía Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Farrera, Arodi. Universidad Nacional Autónoma de México; MéxicoFil: Jaramillo, Claudia. Universidad de Antioquia; ColombiaFil: Williams Arias. Universidad de Antioquia; ColombiaFil: Fuentes, Macarena. Universidad de Tarapacá; ChileFil: Everardo, Paola. Instituto Nacional de Antropología E Historia; MéxicoFil: de Avila, Francisco. Instituto Nacional de Antropología E Historia; MéxicoFil: Gomez Valdés, Jorge. Universidad Nacional Autónoma de México; MéxicoFil: Hünemeier, Tábita. Universidade Federal do Rio Grande do Sul; BrasilFil: Gibbon, Shara. University College London; Estados UnidosFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Rosique, Javier. Universidad de Antioquia; ColombiaFil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; BrasilFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Bedoya, Gabriel. Universidad de Antioquia; ColombiaFil: Ruiz Linares, Andres. University College London; Estados UnidosFil: Gonzalez Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaWiley2015-01-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/19966Quinto Sanchez, Mirsha Emmanuel; Adhikari, Kaustubh; Acuña Alonzo, Victor; Cintas, Celia; Silva de Cerqueira, Caio Cesar; et al.; Facial asymmetry and genetic ancestry in Latin American admixed populations; Wiley; American Journal Of Physical Anthropology; 157; 1; 12-1-2015; 58-700002-9483CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22688/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.22688info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:27Zoai:ri.conicet.gov.ar:11336/19966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:28.203CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Facial asymmetry and genetic ancestry in Latin American admixed populations
title Facial asymmetry and genetic ancestry in Latin American admixed populations
spellingShingle Facial asymmetry and genetic ancestry in Latin American admixed populations
Quinto Sanchez, Mirsha Emmanuel
Facial Directional Asymmetry
Facial Fluctuating Asymmetry
Genetic Ancestry
Latin America
Geometric Morphometrics
title_short Facial asymmetry and genetic ancestry in Latin American admixed populations
title_full Facial asymmetry and genetic ancestry in Latin American admixed populations
title_fullStr Facial asymmetry and genetic ancestry in Latin American admixed populations
title_full_unstemmed Facial asymmetry and genetic ancestry in Latin American admixed populations
title_sort Facial asymmetry and genetic ancestry in Latin American admixed populations
dc.creator.none.fl_str_mv Quinto Sanchez, Mirsha Emmanuel
Adhikari, Kaustubh
Acuña Alonzo, Victor
Cintas, Celia
Silva de Cerqueira, Caio Cesar
Ramallo, Virginia
Castillo, Lucía Daniela
Farrera, Arodi
Jaramillo, Claudia
Williams Arias
Fuentes, Macarena
Everardo, Paola
de Avila, Francisco
Gomez Valdés, Jorge
Hünemeier, Tábita
Gibbon, Shara
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz Linares, Andres
Gonzalez Jose, Rolando
author Quinto Sanchez, Mirsha Emmanuel
author_facet Quinto Sanchez, Mirsha Emmanuel
Adhikari, Kaustubh
Acuña Alonzo, Victor
Cintas, Celia
Silva de Cerqueira, Caio Cesar
Ramallo, Virginia
Castillo, Lucía Daniela
Farrera, Arodi
Jaramillo, Claudia
Williams Arias
Fuentes, Macarena
Everardo, Paola
de Avila, Francisco
Gomez Valdés, Jorge
Hünemeier, Tábita
Gibbon, Shara
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz Linares, Andres
Gonzalez Jose, Rolando
author_role author
author2 Adhikari, Kaustubh
Acuña Alonzo, Victor
Cintas, Celia
Silva de Cerqueira, Caio Cesar
Ramallo, Virginia
Castillo, Lucía Daniela
Farrera, Arodi
Jaramillo, Claudia
Williams Arias
Fuentes, Macarena
Everardo, Paola
de Avila, Francisco
Gomez Valdés, Jorge
Hünemeier, Tábita
Gibbon, Shara
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz Linares, Andres
Gonzalez Jose, Rolando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Facial Directional Asymmetry
Facial Fluctuating Asymmetry
Genetic Ancestry
Latin America
Geometric Morphometrics
topic Facial Directional Asymmetry
Facial Fluctuating Asymmetry
Genetic Ancestry
Latin America
Geometric Morphometrics
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise.
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Adhikari, Kaustubh. University College London; Estados Unidos
Fil: Acuña Alonzo, Victor. University College London; Estados Unidos. Instituto Nacional de Antropología E Historia; México
Fil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Castillo, Lucía Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Farrera, Arodi. Universidad Nacional Autónoma de México; México
Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia
Fil: Williams Arias. Universidad de Antioquia; Colombia
Fil: Fuentes, Macarena. Universidad de Tarapacá; Chile
Fil: Everardo, Paola. Instituto Nacional de Antropología E Historia; México
Fil: de Avila, Francisco. Instituto Nacional de Antropología E Historia; México
Fil: Gomez Valdés, Jorge. Universidad Nacional Autónoma de México; México
Fil: Hünemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gibbon, Shara. University College London; Estados Unidos
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Ruiz Linares, Andres. University College London; Estados Unidos
Fil: Gonzalez Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
description Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/19966
Quinto Sanchez, Mirsha Emmanuel; Adhikari, Kaustubh; Acuña Alonzo, Victor; Cintas, Celia; Silva de Cerqueira, Caio Cesar; et al.; Facial asymmetry and genetic ancestry in Latin American admixed populations; Wiley; American Journal Of Physical Anthropology; 157; 1; 12-1-2015; 58-70
0002-9483
CONICET Digital
CONICET
url http://hdl.handle.net/11336/19966
identifier_str_mv Quinto Sanchez, Mirsha Emmanuel; Adhikari, Kaustubh; Acuña Alonzo, Victor; Cintas, Celia; Silva de Cerqueira, Caio Cesar; et al.; Facial asymmetry and genetic ancestry in Latin American admixed populations; Wiley; American Journal Of Physical Anthropology; 157; 1; 12-1-2015; 58-70
0002-9483
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22688/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.22688
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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