Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats

Autores
Farah, Daniela; Nunes, Jonas; Sartori, Michelle; Da Silva Dias, Danielle; Sirvente, Raquel; Silva, Maikon B.; Fiorino, Patrícia; Morris, Mariana; Llesuy, Susana Francisca; Farah, Vera; Irigoyen, Maria Cláudia; De Angelis, Kátia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)-SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
Fil: Farah, Daniela. Universidade Presbiteriana Mackenzie; Brasil. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Nunes, Jonas. Universidade Presbiteriana Mackenzie; Brasil
Fil: Sartori, Michelle. Universidade Nove de Julho; Brasil. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Sirvente, Raquel. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Silva, Maikon B.. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Fiorino, Patrícia. Universidade Presbiteriana Mackenzie; Brasil
Fil: Morris, Mariana. Nova Southeastern University; Estados Unidos
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Farah, Vera. Universidade Presbiteriana Mackenzie; Brasil
Fil: Irigoyen, Maria Cláudia. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: De Angelis, Kátia. Universidade Nove de Julho; Brasil
Materia
SOBREDOSIS DE FRUCTOSA
PATOLOGIA CARDIOVASCULAR
ESTRES OXIDATIVO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47592
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47592
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exercise training prevents cardiovascular derangements induced by fructose overload in developing ratsFarah, DanielaNunes, JonasSartori, MichelleDa Silva Dias, DanielleSirvente, RaquelSilva, Maikon B.Fiorino, PatríciaMorris, MarianaLlesuy, Susana FranciscaFarah, VeraIrigoyen, Maria CláudiaDe Angelis, KátiaSOBREDOSIS DE FRUCTOSAPATOLOGIA CARDIOVASCULARESTRES OXIDATIVOhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)-SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.Fil: Farah, Daniela. Universidade Presbiteriana Mackenzie; Brasil. Hospital Das Clinicas. Instituto Do Coracao; BrasilFil: Nunes, Jonas. Universidade Presbiteriana Mackenzie; BrasilFil: Sartori, Michelle. Universidade Nove de Julho; Brasil. Hospital Das Clinicas. Instituto Do Coracao; BrasilFil: Da Silva Dias, Danielle. Universidade Nove de Julho; BrasilFil: Sirvente, Raquel. Hospital Das Clinicas. Instituto Do Coracao; BrasilFil: Silva, Maikon B.. Hospital Das Clinicas. Instituto Do Coracao; BrasilFil: Fiorino, Patrícia. Universidade Presbiteriana Mackenzie; BrasilFil: Morris, Mariana. Nova Southeastern University; Estados UnidosFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Farah, Vera. Universidade Presbiteriana Mackenzie; BrasilFil: Irigoyen, Maria Cláudia. Hospital Das Clinicas. Instituto Do Coracao; BrasilFil: De Angelis, Kátia. Universidade Nove de Julho; BrasilPublic Library of Science2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47592Farah, Daniela; Nunes, Jonas; Sartori, Michelle; Da Silva Dias, Danielle; Sirvente, Raquel; et al.; Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats; Public Library of Science; Plos One; 11; 12; 12-2016; 1-151932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0167291info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167291info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:38:08Zoai:ri.conicet.gov.ar:11336/47592instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:38:08.531CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
title Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
spellingShingle Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
Farah, Daniela
SOBREDOSIS DE FRUCTOSA
PATOLOGIA CARDIOVASCULAR
ESTRES OXIDATIVO
title_short Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
title_full Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
title_fullStr Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
title_full_unstemmed Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
title_sort Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats
dc.creator.none.fl_str_mv Farah, Daniela
Nunes, Jonas
Sartori, Michelle
Da Silva Dias, Danielle
Sirvente, Raquel
Silva, Maikon B.
Fiorino, Patrícia
Morris, Mariana
Llesuy, Susana Francisca
Farah, Vera
Irigoyen, Maria Cláudia
De Angelis, Kátia
author Farah, Daniela
author_facet Farah, Daniela
Nunes, Jonas
Sartori, Michelle
Da Silva Dias, Danielle
Sirvente, Raquel
Silva, Maikon B.
Fiorino, Patrícia
Morris, Mariana
Llesuy, Susana Francisca
Farah, Vera
Irigoyen, Maria Cláudia
De Angelis, Kátia
author_role author
author2 Nunes, Jonas
Sartori, Michelle
Da Silva Dias, Danielle
Sirvente, Raquel
Silva, Maikon B.
Fiorino, Patrícia
Morris, Mariana
Llesuy, Susana Francisca
Farah, Vera
Irigoyen, Maria Cláudia
De Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SOBREDOSIS DE FRUCTOSA
PATOLOGIA CARDIOVASCULAR
ESTRES OXIDATIVO
topic SOBREDOSIS DE FRUCTOSA
PATOLOGIA CARDIOVASCULAR
ESTRES OXIDATIVO
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)-SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
Fil: Farah, Daniela. Universidade Presbiteriana Mackenzie; Brasil. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Nunes, Jonas. Universidade Presbiteriana Mackenzie; Brasil
Fil: Sartori, Michelle. Universidade Nove de Julho; Brasil. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Sirvente, Raquel. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Silva, Maikon B.. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: Fiorino, Patrícia. Universidade Presbiteriana Mackenzie; Brasil
Fil: Morris, Mariana. Nova Southeastern University; Estados Unidos
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Farah, Vera. Universidade Presbiteriana Mackenzie; Brasil
Fil: Irigoyen, Maria Cláudia. Hospital Das Clinicas. Instituto Do Coracao; Brasil
Fil: De Angelis, Kátia. Universidade Nove de Julho; Brasil
description The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)-SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47592
Farah, Daniela; Nunes, Jonas; Sartori, Michelle; Da Silva Dias, Danielle; Sirvente, Raquel; et al.; Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats; Public Library of Science; Plos One; 11; 12; 12-2016; 1-15
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47592
identifier_str_mv Farah, Daniela; Nunes, Jonas; Sartori, Michelle; Da Silva Dias, Danielle; Sirvente, Raquel; et al.; Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats; Public Library of Science; Plos One; 11; 12; 12-2016; 1-15
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0167291
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167291
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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