Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats

Autores
Peredo, Horacio Angel; Andrade, V.; Donoso, Adriana Susana; Lee, H. J.; Puyó, Ana María
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
1. Fructose (F) overload produces elevated blood pressure (BP), hyperglycaemia, hypertriglyceridemia and insulin resistance, resembling human metabolic syndrome. Previously, we found altered vascular prostanoid (PR) production in this model. 2. Sodium molybdate (Mo), as well as sodium tungstate, causes insulin-like effects and normalizes plasma glucose levels in streptozotocin-treated diabetic rats. We studied the effects of Mo on BP, metabolic parameters and release of PR from the mesenteric vascular bed (MVB) in F-overloaded rats. 3. Four groups of male Sprague-Dawley rats were analysed: Control, tap water to drink; F, F solution 10% W/V to drink; CMo, Mo 100 mg kg day 1 and FMo, both treatments. After 9 weeks, the animals were killed and MVBs removed and the released PRs measured. 4. F increased BP, glycemia, triglyceridemia and insulinemia. Mo treatment prevented the increases in BP and glycemia, but did not modify triglyceridemia or insulinemia. In addition, Mo decreased BP in controls. 5. Prostaglandins (PG) F2alpha and E2, PG 6-ketoF1alpha and thromboxane (TX) B2, as well as inactive metabolites of prostacyclin (PGI2) and TXA2 were detected. F decreased the production of vasodilator PRs PGI2 and PGE2 in MVB. Mo prevented these alterations and increased PGE2 in controls. Vasoconstrict or PRs PGF2alpha and TXA2 release was not modified. 6. Mo treatment, beyond its known lowering effect on glycemia, prevents the reduction in the vascular release of vasodilator PR observed in this model. This could be one of the mechanisms by which Mo avoids the increase in BP caused by F overload in the rat.
Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Fil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Fil: Lee, H. J.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Materia
Molybdate
Fructose
Hypertension
Prostanoids
Metabolic Syndrome
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1919
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/1919
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded ratsPeredo, Horacio AngelAndrade, V.Donoso, Adriana SusanaLee, H. J.Puyó, Ana MaríaMolybdateFructoseHypertensionProstanoidsMetabolic Syndromehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/31. Fructose (F) overload produces elevated blood pressure (BP), hyperglycaemia, hypertriglyceridemia and insulin resistance, resembling human metabolic syndrome. Previously, we found altered vascular prostanoid (PR) production in this model. 2. Sodium molybdate (Mo), as well as sodium tungstate, causes insulin-like effects and normalizes plasma glucose levels in streptozotocin-treated diabetic rats. We studied the effects of Mo on BP, metabolic parameters and release of PR from the mesenteric vascular bed (MVB) in F-overloaded rats. 3. Four groups of male Sprague-Dawley rats were analysed: Control, tap water to drink; F, F solution 10% W/V to drink; CMo, Mo 100 mg kg day 1 and FMo, both treatments. After 9 weeks, the animals were killed and MVBs removed and the released PRs measured. 4. F increased BP, glycemia, triglyceridemia and insulinemia. Mo treatment prevented the increases in BP and glycemia, but did not modify triglyceridemia or insulinemia. In addition, Mo decreased BP in controls. 5. Prostaglandins (PG) F2alpha and E2, PG 6-ketoF1alpha and thromboxane (TX) B2, as well as inactive metabolites of prostacyclin (PGI2) and TXA2 were detected. F decreased the production of vasodilator PRs PGI2 and PGE2 in MVB. Mo prevented these alterations and increased PGE2 in controls. Vasoconstrict or PRs PGF2alpha and TXA2 release was not modified. 6. Mo treatment, beyond its known lowering effect on glycemia, prevents the reduction in the vascular release of vasodilator PR observed in this model. This could be one of the mechanisms by which Mo avoids the increase in BP caused by F overload in the rat.Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;Fil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;Fil: Lee, H. J.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;Wiley2013-08-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1919Peredo, Horacio Angel; Andrade, V.; Donoso, Adriana Susana; Lee, H. J.; Puyó, Ana María; Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats; Wiley; Autonomic and Autacoid Pharmacology; 33; 3-4; 02-8-2013; 43-481474-8673enginfo:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/23906370info:eu-repo/semantics/altIdentifier/doi/DOI:10.1111/aap.12010info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aap.12010/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:30Zoai:ri.conicet.gov.ar:11336/1919instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:30.42CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
title Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
spellingShingle Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
Peredo, Horacio Angel
Molybdate
Fructose
Hypertension
Prostanoids
Metabolic Syndrome
title_short Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
title_full Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
title_fullStr Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
title_full_unstemmed Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
title_sort Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats
dc.creator.none.fl_str_mv Peredo, Horacio Angel
Andrade, V.
Donoso, Adriana Susana
Lee, H. J.
Puyó, Ana María
author Peredo, Horacio Angel
author_facet Peredo, Horacio Angel
Andrade, V.
Donoso, Adriana Susana
Lee, H. J.
Puyó, Ana María
author_role author
author2 Andrade, V.
Donoso, Adriana Susana
Lee, H. J.
Puyó, Ana María
author2_role author
author
author
author
dc.subject.none.fl_str_mv Molybdate
Fructose
Hypertension
Prostanoids
Metabolic Syndrome
topic Molybdate
Fructose
Hypertension
Prostanoids
Metabolic Syndrome
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv 1. Fructose (F) overload produces elevated blood pressure (BP), hyperglycaemia, hypertriglyceridemia and insulin resistance, resembling human metabolic syndrome. Previously, we found altered vascular prostanoid (PR) production in this model. 2. Sodium molybdate (Mo), as well as sodium tungstate, causes insulin-like effects and normalizes plasma glucose levels in streptozotocin-treated diabetic rats. We studied the effects of Mo on BP, metabolic parameters and release of PR from the mesenteric vascular bed (MVB) in F-overloaded rats. 3. Four groups of male Sprague-Dawley rats were analysed: Control, tap water to drink; F, F solution 10% W/V to drink; CMo, Mo 100 mg kg day 1 and FMo, both treatments. After 9 weeks, the animals were killed and MVBs removed and the released PRs measured. 4. F increased BP, glycemia, triglyceridemia and insulinemia. Mo treatment prevented the increases in BP and glycemia, but did not modify triglyceridemia or insulinemia. In addition, Mo decreased BP in controls. 5. Prostaglandins (PG) F2alpha and E2, PG 6-ketoF1alpha and thromboxane (TX) B2, as well as inactive metabolites of prostacyclin (PGI2) and TXA2 were detected. F decreased the production of vasodilator PRs PGI2 and PGE2 in MVB. Mo prevented these alterations and increased PGE2 in controls. Vasoconstrict or PRs PGF2alpha and TXA2 release was not modified. 6. Mo treatment, beyond its known lowering effect on glycemia, prevents the reduction in the vascular release of vasodilator PR observed in this model. This could be one of the mechanisms by which Mo avoids the increase in BP caused by F overload in the rat.
Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Fil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Fil: Lee, H. J.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
description 1. Fructose (F) overload produces elevated blood pressure (BP), hyperglycaemia, hypertriglyceridemia and insulin resistance, resembling human metabolic syndrome. Previously, we found altered vascular prostanoid (PR) production in this model. 2. Sodium molybdate (Mo), as well as sodium tungstate, causes insulin-like effects and normalizes plasma glucose levels in streptozotocin-treated diabetic rats. We studied the effects of Mo on BP, metabolic parameters and release of PR from the mesenteric vascular bed (MVB) in F-overloaded rats. 3. Four groups of male Sprague-Dawley rats were analysed: Control, tap water to drink; F, F solution 10% W/V to drink; CMo, Mo 100 mg kg day 1 and FMo, both treatments. After 9 weeks, the animals were killed and MVBs removed and the released PRs measured. 4. F increased BP, glycemia, triglyceridemia and insulinemia. Mo treatment prevented the increases in BP and glycemia, but did not modify triglyceridemia or insulinemia. In addition, Mo decreased BP in controls. 5. Prostaglandins (PG) F2alpha and E2, PG 6-ketoF1alpha and thromboxane (TX) B2, as well as inactive metabolites of prostacyclin (PGI2) and TXA2 were detected. F decreased the production of vasodilator PRs PGI2 and PGE2 in MVB. Mo prevented these alterations and increased PGE2 in controls. Vasoconstrict or PRs PGF2alpha and TXA2 release was not modified. 6. Mo treatment, beyond its known lowering effect on glycemia, prevents the reduction in the vascular release of vasodilator PR observed in this model. This could be one of the mechanisms by which Mo avoids the increase in BP caused by F overload in the rat.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1919
Peredo, Horacio Angel; Andrade, V.; Donoso, Adriana Susana; Lee, H. J.; Puyó, Ana María; Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats; Wiley; Autonomic and Autacoid Pharmacology; 33; 3-4; 02-8-2013; 43-48
1474-8673
url http://hdl.handle.net/11336/1919
identifier_str_mv Peredo, Horacio Angel; Andrade, V.; Donoso, Adriana Susana; Lee, H. J.; Puyó, Ana María; Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose overloaded rats; Wiley; Autonomic and Autacoid Pharmacology; 33; 3-4; 02-8-2013; 43-48
1474-8673
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/23906370
info:eu-repo/semantics/altIdentifier/doi/DOI:10.1111/aap.12010
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aap.12010/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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