Evolutionary trends in antifungal resistance: a meta-analysis.

Autores
Niu, Xueke; Al Hatmi, Abdullah M. S.; Vitale, Roxana Gabriela; Lackner, Micaela; Ahmed, Sarah A.; Verweij, Paul; Kang, Yingqian; de Hoog, Sybren
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders (Hypocreales, Microascales, and Mucorales) invariably showed resistance. Also the basidiomycetous orders Agaricales, Polyporales, Sporidiales, Tremellales, and Trichosporonales showed relatively high degrees of azole multi-resistance, while elsewhere in the fungal kingdom, including orders with numerous pathogenic and opportunistic species, that is, Onygenales, Chaetothyiales, Sordariales, and Malasseziales, in general were susceptible to azoles. In most cases, resistance vs susceptibility was consistently associated with phylogenetic distance, members of the same order showing similar behavior.
Fil: Niu, Xueke. Guizhou Medical University; China
Fil: Al Hatmi, Abdullah M. S.. University of Nizwa; Omán
Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Lackner, Micaela. Medical University of Innsbruck; Austria
Fil: Ahmed, Sarah A.. Canisius Wilhelmina Hospital; Países Bajos
Fil: Verweij, Paul. Canisius Wilhelmina Hospital; Países Bajos
Fil: Kang, Yingqian. Guizhou Medical University; China
Fil: de Hoog, Sybren. Guizhou Medical University; China
Materia
ANTIFUNGAL RESISTANCE
META ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/235153
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evolutionary trends in antifungal resistance: a meta-analysis.Niu, XuekeAl Hatmi, Abdullah M. S.Vitale, Roxana GabrielaLackner, MicaelaAhmed, Sarah A.Verweij, PaulKang, Yingqiande Hoog, SybrenANTIFUNGAL RESISTANCEMETA ANALYSIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders (Hypocreales, Microascales, and Mucorales) invariably showed resistance. Also the basidiomycetous orders Agaricales, Polyporales, Sporidiales, Tremellales, and Trichosporonales showed relatively high degrees of azole multi-resistance, while elsewhere in the fungal kingdom, including orders with numerous pathogenic and opportunistic species, that is, Onygenales, Chaetothyiales, Sordariales, and Malasseziales, in general were susceptible to azoles. In most cases, resistance vs susceptibility was consistently associated with phylogenetic distance, members of the same order showing similar behavior.Fil: Niu, Xueke. Guizhou Medical University; ChinaFil: Al Hatmi, Abdullah M. S.. University of Nizwa; OmánFil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Lackner, Micaela. Medical University of Innsbruck; AustriaFil: Ahmed, Sarah A.. Canisius Wilhelmina Hospital; Países BajosFil: Verweij, Paul. Canisius Wilhelmina Hospital; Países BajosFil: Kang, Yingqian. Guizhou Medical University; ChinaFil: de Hoog, Sybren. Guizhou Medical University; ChinaAmerican Society for Microbiology2024-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/235153Niu, Xueke; Al Hatmi, Abdullah M. S. ; Vitale, Roxana Gabriela; Lackner, Micaela; Ahmed, Sarah A.; et al.; Evolutionary trends in antifungal resistance: a meta-analysis.; American Society for Microbiology; Microbiology Spectrum; 12; 4; 5-2024; 1-192165-0497CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/spectrum.02127-23info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:02Zoai:ri.conicet.gov.ar:11336/235153instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:02.575CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evolutionary trends in antifungal resistance: a meta-analysis.
title Evolutionary trends in antifungal resistance: a meta-analysis.
spellingShingle Evolutionary trends in antifungal resistance: a meta-analysis.
Niu, Xueke
ANTIFUNGAL RESISTANCE
META ANALYSIS
title_short Evolutionary trends in antifungal resistance: a meta-analysis.
title_full Evolutionary trends in antifungal resistance: a meta-analysis.
title_fullStr Evolutionary trends in antifungal resistance: a meta-analysis.
title_full_unstemmed Evolutionary trends in antifungal resistance: a meta-analysis.
title_sort Evolutionary trends in antifungal resistance: a meta-analysis.
dc.creator.none.fl_str_mv Niu, Xueke
Al Hatmi, Abdullah M. S.
Vitale, Roxana Gabriela
Lackner, Micaela
Ahmed, Sarah A.
Verweij, Paul
Kang, Yingqian
de Hoog, Sybren
author Niu, Xueke
author_facet Niu, Xueke
Al Hatmi, Abdullah M. S.
Vitale, Roxana Gabriela
Lackner, Micaela
Ahmed, Sarah A.
Verweij, Paul
Kang, Yingqian
de Hoog, Sybren
author_role author
author2 Al Hatmi, Abdullah M. S.
Vitale, Roxana Gabriela
Lackner, Micaela
Ahmed, Sarah A.
Verweij, Paul
Kang, Yingqian
de Hoog, Sybren
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIFUNGAL RESISTANCE
META ANALYSIS
topic ANTIFUNGAL RESISTANCE
META ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders (Hypocreales, Microascales, and Mucorales) invariably showed resistance. Also the basidiomycetous orders Agaricales, Polyporales, Sporidiales, Tremellales, and Trichosporonales showed relatively high degrees of azole multi-resistance, while elsewhere in the fungal kingdom, including orders with numerous pathogenic and opportunistic species, that is, Onygenales, Chaetothyiales, Sordariales, and Malasseziales, in general were susceptible to azoles. In most cases, resistance vs susceptibility was consistently associated with phylogenetic distance, members of the same order showing similar behavior.
Fil: Niu, Xueke. Guizhou Medical University; China
Fil: Al Hatmi, Abdullah M. S.. University of Nizwa; Omán
Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Lackner, Micaela. Medical University of Innsbruck; Austria
Fil: Ahmed, Sarah A.. Canisius Wilhelmina Hospital; Países Bajos
Fil: Verweij, Paul. Canisius Wilhelmina Hospital; Países Bajos
Fil: Kang, Yingqian. Guizhou Medical University; China
Fil: de Hoog, Sybren. Guizhou Medical University; China
description The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders (Hypocreales, Microascales, and Mucorales) invariably showed resistance. Also the basidiomycetous orders Agaricales, Polyporales, Sporidiales, Tremellales, and Trichosporonales showed relatively high degrees of azole multi-resistance, while elsewhere in the fungal kingdom, including orders with numerous pathogenic and opportunistic species, that is, Onygenales, Chaetothyiales, Sordariales, and Malasseziales, in general were susceptible to azoles. In most cases, resistance vs susceptibility was consistently associated with phylogenetic distance, members of the same order showing similar behavior.
publishDate 2024
dc.date.none.fl_str_mv 2024-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/235153
Niu, Xueke; Al Hatmi, Abdullah M. S. ; Vitale, Roxana Gabriela; Lackner, Micaela; Ahmed, Sarah A.; et al.; Evolutionary trends in antifungal resistance: a meta-analysis.; American Society for Microbiology; Microbiology Spectrum; 12; 4; 5-2024; 1-19
2165-0497
CONICET Digital
CONICET
url http://hdl.handle.net/11336/235153
identifier_str_mv Niu, Xueke; Al Hatmi, Abdullah M. S. ; Vitale, Roxana Gabriela; Lackner, Micaela; Ahmed, Sarah A.; et al.; Evolutionary trends in antifungal resistance: a meta-analysis.; American Society for Microbiology; Microbiology Spectrum; 12; 4; 5-2024; 1-19
2165-0497
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/spectrum.02127-23
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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