Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents

Autores
Spampinato, Claudia Patricia; Leonardi, Darío
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal infections are often life-threatening, probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies. Here, we briefly review our current knowledge of pathogenic species of the genus Candida and yeast infection causes and then focus on current antifungal drugs and resistance mechanisms. An overview of new therapeutic alternatives for the treatment of Candida infections is also provided.
Fil: Spampinato, Claudia Patricia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Fil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Materia
CANDIDA INFECTIONS
ANTIFUNGAL AGENTS
RESISTANCE MECHANISMS
ALTERNATIVE AGENTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3438
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agentsSpampinato, Claudia PatriciaLeonardi, DaríoCANDIDA INFECTIONSANTIFUNGAL AGENTSRESISTANCE MECHANISMSALTERNATIVE AGENTShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal infections are often life-threatening, probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies. Here, we briefly review our current knowledge of pathogenic species of the genus Candida and yeast infection causes and then focus on current antifungal drugs and resistance mechanisms. An overview of new therapeutic alternatives for the treatment of Candida infections is also provided.Fil: Spampinato, Claudia Patricia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); ArgentinaFil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); ArgentinaHindawi Publishing Corporation2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3438Spampinato, Claudia Patricia; Leonardi, Darío; Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents; Hindawi Publishing Corporation; Journal Of Biomedicine And Biotechnology; 2013; 6-2013; 1-131110-7243http://dx.doi.org/10.1155/2013/204237enginfo:eu-repo/semantics/altIdentifier/ark/10.1155/2013/204237info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:54Zoai:ri.conicet.gov.ar:11336/3438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:54.43CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
title Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
spellingShingle Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
Spampinato, Claudia Patricia
CANDIDA INFECTIONS
ANTIFUNGAL AGENTS
RESISTANCE MECHANISMS
ALTERNATIVE AGENTS
title_short Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
title_full Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
title_fullStr Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
title_full_unstemmed Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
title_sort Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
dc.creator.none.fl_str_mv Spampinato, Claudia Patricia
Leonardi, Darío
author Spampinato, Claudia Patricia
author_facet Spampinato, Claudia Patricia
Leonardi, Darío
author_role author
author2 Leonardi, Darío
author2_role author
dc.subject.none.fl_str_mv CANDIDA INFECTIONS
ANTIFUNGAL AGENTS
RESISTANCE MECHANISMS
ALTERNATIVE AGENTS
topic CANDIDA INFECTIONS
ANTIFUNGAL AGENTS
RESISTANCE MECHANISMS
ALTERNATIVE AGENTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal infections are often life-threatening, probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies. Here, we briefly review our current knowledge of pathogenic species of the genus Candida and yeast infection causes and then focus on current antifungal drugs and resistance mechanisms. An overview of new therapeutic alternatives for the treatment of Candida infections is also provided.
Fil: Spampinato, Claudia Patricia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Fil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
description The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal infections are often life-threatening, probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies. Here, we briefly review our current knowledge of pathogenic species of the genus Candida and yeast infection causes and then focus on current antifungal drugs and resistance mechanisms. An overview of new therapeutic alternatives for the treatment of Candida infections is also provided.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3438
Spampinato, Claudia Patricia; Leonardi, Darío; Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents; Hindawi Publishing Corporation; Journal Of Biomedicine And Biotechnology; 2013; 6-2013; 1-13
1110-7243
http://dx.doi.org/10.1155/2013/204237
url http://hdl.handle.net/11336/3438
http://dx.doi.org/10.1155/2013/204237
identifier_str_mv Spampinato, Claudia Patricia; Leonardi, Darío; Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents; Hindawi Publishing Corporation; Journal Of Biomedicine And Biotechnology; 2013; 6-2013; 1-13
1110-7243
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/ark/10.1155/2013/204237
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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