Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin

Autores
Rodriguez, Myriam E.; Fernández, Daniel A.; Awruch, Josefina; Braslavsky, Silvia E.; Dicelio, Lelia Elina
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role.
Fil: Rodriguez, Myriam E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Fernández, Daniel A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Awruch, Josefina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Braslavsky, Silvia E.. Max Planck Institute For Chemical Energy Conversion; Alemania
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Materia
AGGREGATION
ALBUMIN
HYDROPHOBIC INTERACTIONS
MICELLES
TETRAKIS(1,1- DIMETHYL-2-TRIMETHYLAMMONIUM)ETHYLPHTHALOCYANINATO ZINC(II) TETRAIODIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112794
Acceder
id CONICETDig_1cd3d95eba145f2d83231e572ac5da6b
oai_identifier_str oai:ri.conicet.gov.ar:11336/112794
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albuminRodriguez, Myriam E.Fernández, Daniel A.Awruch, JosefinaBraslavsky, Silvia E.Dicelio, Lelia ElinaAGGREGATIONALBUMINHYDROPHOBIC INTERACTIONSMICELLESTETRAKIS(1,1- DIMETHYL-2-TRIMETHYLAMMONIUM)ETHYLPHTHALOCYANINATO ZINC(II) TETRAIODIDEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role.Fil: Rodriguez, Myriam E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Fernández, Daniel A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Awruch, Josefina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Braslavsky, Silvia E.. Max Planck Institute For Chemical Energy Conversion; AlemaniaFil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaWorld Scientific2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112794Rodriguez, Myriam E.; Fernández, Daniel A.; Awruch, Josefina; Braslavsky, Silvia E.; Dicelio, Lelia Elina; Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin; World Scientific; Journal Of Porphyrins And Phthalocyanines; 10; 1; 12-2006; 33-421088-4246CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S1088424606000053info:eu-repo/semantics/altIdentifier/doi/10.1142/S1088424606000053info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:26Zoai:ri.conicet.gov.ar:11336/112794instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:26.442CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
spellingShingle Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
Rodriguez, Myriam E.
AGGREGATION
ALBUMIN
HYDROPHOBIC INTERACTIONS
MICELLES
TETRAKIS(1,1- DIMETHYL-2-TRIMETHYLAMMONIUM)ETHYLPHTHALOCYANINATO ZINC(II) TETRAIODIDE
title_short Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_full Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_fullStr Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_full_unstemmed Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_sort Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
dc.creator.none.fl_str_mv Rodriguez, Myriam E.
Fernández, Daniel A.
Awruch, Josefina
Braslavsky, Silvia E.
Dicelio, Lelia Elina
author Rodriguez, Myriam E.
author_facet Rodriguez, Myriam E.
Fernández, Daniel A.
Awruch, Josefina
Braslavsky, Silvia E.
Dicelio, Lelia Elina
author_role author
author2 Fernández, Daniel A.
Awruch, Josefina
Braslavsky, Silvia E.
Dicelio, Lelia Elina
author2_role author
author
author
author
dc.subject.none.fl_str_mv AGGREGATION
ALBUMIN
HYDROPHOBIC INTERACTIONS
MICELLES
TETRAKIS(1,1- DIMETHYL-2-TRIMETHYLAMMONIUM)ETHYLPHTHALOCYANINATO ZINC(II) TETRAIODIDE
topic AGGREGATION
ALBUMIN
HYDROPHOBIC INTERACTIONS
MICELLES
TETRAKIS(1,1- DIMETHYL-2-TRIMETHYLAMMONIUM)ETHYLPHTHALOCYANINATO ZINC(II) TETRAIODIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role.
Fil: Rodriguez, Myriam E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Fernández, Daniel A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Awruch, Josefina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Braslavsky, Silvia E.. Max Planck Institute For Chemical Energy Conversion; Alemania
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
description The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112794
Rodriguez, Myriam E.; Fernández, Daniel A.; Awruch, Josefina; Braslavsky, Silvia E.; Dicelio, Lelia Elina; Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin; World Scientific; Journal Of Porphyrins And Phthalocyanines; 10; 1; 12-2006; 33-42
1088-4246
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112794
identifier_str_mv Rodriguez, Myriam E.; Fernández, Daniel A.; Awruch, Josefina; Braslavsky, Silvia E.; Dicelio, Lelia Elina; Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin; World Scientific; Journal Of Porphyrins And Phthalocyanines; 10; 1; 12-2006; 33-42
1088-4246
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S1088424606000053
info:eu-repo/semantics/altIdentifier/doi/10.1142/S1088424606000053
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Scientific
publisher.none.fl_str_mv World Scientific
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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