Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity

Autores
Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Deviggiano, Alejandro; Capunay, Carlos; De Zan, Macarena C.; Goldsmit, Alejandro; Campisi, Roxana
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: We sought to explore the relationship between pericardial fat volume (PFV) and both coronary atherosclerosis (CA) extent and severity using coronary artery calcium score (CAC), computed tomography coronary angiography (CTCA), and invasive coronary angiography in patients at high to intermediate likelihood of coronary artery disease (CAD). Methods and results: Patients clinically referred to invasive angiography who underwent CTCA and CAC within 1 month before the procedure comprised the study population. PFV, CAC, atherosclerotic burden indexes [segment involvement score (SIS); segment stenosis score; three-vessel plaque; and any left main plaque], and the invasive angiography-derived CAD index were evaluated independently. A total of 75 patients were included in the study. PFV did not differ between patients with or without obstructive (stenosis .70%) CAD defined by invasive angiography (86.4±31.7 vs. 77.1±42.8 cm3, P = 0.34), although patients with obstructive CAD had significantly higher CAC scores [636.0 (IQR 229.5-1101.0) vs. 206.0 (IQR 0.0-675), P<0.0001] than patients without obstructive CAD. Patients with extensive CA (SIS . 5) had significantly larger PFV (89.9±33.9 vs. 58.7±33.2 cm3, P = 0.003) than patients with non-extensive CA. Significant correlations were found between PFV and CAC (r = 0.49, P<0.0001), and SIS (r = 0.46, P<0.0001), whereas very weak correlations were observed between PFV and the CAD index (r = 0.27, P = 0.02), and between PFV and the body mass index (r = 0.33, P = 0.004). Conclusion: The main finding of the present study was the identification of PFV as more closely related to atherosclerotic plaque burden rather than to lesion severity in patients referred to invasive coronary angiography.
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Fil: Deviggiano, Alejandro. Diagnóstico Maipú; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú; Argentina
Fil: De Zan, Macarena C.. Diagnóstico Maipú; Argentina
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
Fil: Campisi, Roxana. Diagnóstico Maipú; Argentina
Materia
Adipose Tissue
Angiography
Atherosclerosis
Calcium
Computed Tomography
Stenosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59620
Acceder
id CONICETDig_1cd32017addc0e059a39ab08427b071d
oai_identifier_str oai:ri.conicet.gov.ar:11336/59620
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severityRodriguez Granillo, Gaston AlfredoCarrascosa, PatriciaDeviggiano, AlejandroCapunay, CarlosDe Zan, Macarena C.Goldsmit, AlejandroCampisi, RoxanaAdipose TissueAngiographyAtherosclerosisCalciumComputed TomographyStenosishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aims: We sought to explore the relationship between pericardial fat volume (PFV) and both coronary atherosclerosis (CA) extent and severity using coronary artery calcium score (CAC), computed tomography coronary angiography (CTCA), and invasive coronary angiography in patients at high to intermediate likelihood of coronary artery disease (CAD). Methods and results: Patients clinically referred to invasive angiography who underwent CTCA and CAC within 1 month before the procedure comprised the study population. PFV, CAC, atherosclerotic burden indexes [segment involvement score (SIS); segment stenosis score; three-vessel plaque; and any left main plaque], and the invasive angiography-derived CAD index were evaluated independently. A total of 75 patients were included in the study. PFV did not differ between patients with or without obstructive (stenosis .70%) CAD defined by invasive angiography (86.4±31.7 vs. 77.1±42.8 cm3, P = 0.34), although patients with obstructive CAD had significantly higher CAC scores [636.0 (IQR 229.5-1101.0) vs. 206.0 (IQR 0.0-675), P<0.0001] than patients without obstructive CAD. Patients with extensive CA (SIS . 5) had significantly larger PFV (89.9±33.9 vs. 58.7±33.2 cm3, P = 0.003) than patients with non-extensive CA. Significant correlations were found between PFV and CAC (r = 0.49, P<0.0001), and SIS (r = 0.46, P<0.0001), whereas very weak correlations were observed between PFV and the CAD index (r = 0.27, P = 0.02), and between PFV and the body mass index (r = 0.33, P = 0.004). Conclusion: The main finding of the present study was the identification of PFV as more closely related to atherosclerotic plaque burden rather than to lesion severity in patients referred to invasive coronary angiography.Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; ArgentinaFil: Carrascosa, Patricia. Diagnóstico Maipú; ArgentinaFil: Deviggiano, Alejandro. Diagnóstico Maipú; ArgentinaFil: Capunay, Carlos. Diagnóstico Maipú; ArgentinaFil: De Zan, Macarena C.. Diagnóstico Maipú; ArgentinaFil: Goldsmit, Alejandro. Sanatorio Güemes; ArgentinaFil: Campisi, Roxana. Diagnóstico Maipú; ArgentinaOxford University Press2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59620Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Deviggiano, Alejandro; Capunay, Carlos; De Zan, Macarena C.; et al.; Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity; Oxford University Press; European Heart Journal. Cardiovascular Imaging; 18; 7; 7-2017; 795-8012047-24042047-2412CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://academic.oup.com/ehjcimaging/article/18/7/795/3060605info:eu-repo/semantics/altIdentifier/doi/10.1093/ehjci/jew139info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:57Zoai:ri.conicet.gov.ar:11336/59620instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:57.495CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
title Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
spellingShingle Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
Rodriguez Granillo, Gaston Alfredo
Adipose Tissue
Angiography
Atherosclerosis
Calcium
Computed Tomography
Stenosis
title_short Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
title_full Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
title_fullStr Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
title_full_unstemmed Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
title_sort Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity
dc.creator.none.fl_str_mv Rodriguez Granillo, Gaston Alfredo
Carrascosa, Patricia
Deviggiano, Alejandro
Capunay, Carlos
De Zan, Macarena C.
Goldsmit, Alejandro
Campisi, Roxana
author Rodriguez Granillo, Gaston Alfredo
author_facet Rodriguez Granillo, Gaston Alfredo
Carrascosa, Patricia
Deviggiano, Alejandro
Capunay, Carlos
De Zan, Macarena C.
Goldsmit, Alejandro
Campisi, Roxana
author_role author
author2 Carrascosa, Patricia
Deviggiano, Alejandro
Capunay, Carlos
De Zan, Macarena C.
Goldsmit, Alejandro
Campisi, Roxana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Adipose Tissue
Angiography
Atherosclerosis
Calcium
Computed Tomography
Stenosis
topic Adipose Tissue
Angiography
Atherosclerosis
Calcium
Computed Tomography
Stenosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: We sought to explore the relationship between pericardial fat volume (PFV) and both coronary atherosclerosis (CA) extent and severity using coronary artery calcium score (CAC), computed tomography coronary angiography (CTCA), and invasive coronary angiography in patients at high to intermediate likelihood of coronary artery disease (CAD). Methods and results: Patients clinically referred to invasive angiography who underwent CTCA and CAC within 1 month before the procedure comprised the study population. PFV, CAC, atherosclerotic burden indexes [segment involvement score (SIS); segment stenosis score; three-vessel plaque; and any left main plaque], and the invasive angiography-derived CAD index were evaluated independently. A total of 75 patients were included in the study. PFV did not differ between patients with or without obstructive (stenosis .70%) CAD defined by invasive angiography (86.4±31.7 vs. 77.1±42.8 cm3, P = 0.34), although patients with obstructive CAD had significantly higher CAC scores [636.0 (IQR 229.5-1101.0) vs. 206.0 (IQR 0.0-675), P<0.0001] than patients without obstructive CAD. Patients with extensive CA (SIS . 5) had significantly larger PFV (89.9±33.9 vs. 58.7±33.2 cm3, P = 0.003) than patients with non-extensive CA. Significant correlations were found between PFV and CAC (r = 0.49, P<0.0001), and SIS (r = 0.46, P<0.0001), whereas very weak correlations were observed between PFV and the CAD index (r = 0.27, P = 0.02), and between PFV and the body mass index (r = 0.33, P = 0.004). Conclusion: The main finding of the present study was the identification of PFV as more closely related to atherosclerotic plaque burden rather than to lesion severity in patients referred to invasive coronary angiography.
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Fil: Deviggiano, Alejandro. Diagnóstico Maipú; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú; Argentina
Fil: De Zan, Macarena C.. Diagnóstico Maipú; Argentina
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
Fil: Campisi, Roxana. Diagnóstico Maipú; Argentina
description Aims: We sought to explore the relationship between pericardial fat volume (PFV) and both coronary atherosclerosis (CA) extent and severity using coronary artery calcium score (CAC), computed tomography coronary angiography (CTCA), and invasive coronary angiography in patients at high to intermediate likelihood of coronary artery disease (CAD). Methods and results: Patients clinically referred to invasive angiography who underwent CTCA and CAC within 1 month before the procedure comprised the study population. PFV, CAC, atherosclerotic burden indexes [segment involvement score (SIS); segment stenosis score; three-vessel plaque; and any left main plaque], and the invasive angiography-derived CAD index were evaluated independently. A total of 75 patients were included in the study. PFV did not differ between patients with or without obstructive (stenosis .70%) CAD defined by invasive angiography (86.4±31.7 vs. 77.1±42.8 cm3, P = 0.34), although patients with obstructive CAD had significantly higher CAC scores [636.0 (IQR 229.5-1101.0) vs. 206.0 (IQR 0.0-675), P<0.0001] than patients without obstructive CAD. Patients with extensive CA (SIS . 5) had significantly larger PFV (89.9±33.9 vs. 58.7±33.2 cm3, P = 0.003) than patients with non-extensive CA. Significant correlations were found between PFV and CAC (r = 0.49, P<0.0001), and SIS (r = 0.46, P<0.0001), whereas very weak correlations were observed between PFV and the CAD index (r = 0.27, P = 0.02), and between PFV and the body mass index (r = 0.33, P = 0.004). Conclusion: The main finding of the present study was the identification of PFV as more closely related to atherosclerotic plaque burden rather than to lesion severity in patients referred to invasive coronary angiography.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59620
Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Deviggiano, Alejandro; Capunay, Carlos; De Zan, Macarena C.; et al.; Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity; Oxford University Press; European Heart Journal. Cardiovascular Imaging; 18; 7; 7-2017; 795-801
2047-2404
2047-2412
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59620
identifier_str_mv Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Deviggiano, Alejandro; Capunay, Carlos; De Zan, Macarena C.; et al.; Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity; Oxford University Press; European Heart Journal. Cardiovascular Imaging; 18; 7; 7-2017; 795-801
2047-2404
2047-2412
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://academic.oup.com/ehjcimaging/article/18/7/795/3060605
info:eu-repo/semantics/altIdentifier/doi/10.1093/ehjci/jew139
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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