Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters

Autores
Mattea, Facundo; Romero, Marcelo Ricardo; Vedelago, José Alberto; Quiroga, Andrés Agustin Ignacio; Valente, Mauro Andres; Strumia, Miriam Cristina
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymer gel dosimeters have specific advantages for recording 3D radiation dose distribution in diagnostic and therapeutic medical applications. A novel system based on itaconic acid and N,N?-methylene-bisacrylamide (BIS) is hereby proposed. The radical polymerization and gel formation of these monomers have been previously studied in the synthesis of a hydrogel for non dosimetric applications. Although the 3D structure of irradiated polymeric dosimeters is usually maintained for long periods of time, it is not possible to eliminate the diffusion of the different species in the regions of dose gradients within the gel. As a consequence the dose information loose quality over time. The mobility within the gelatin structure of the already mentioned species is related to their chemical structure, and nature. In this work the effect of changes in the chemical structure of the monomers over the dosimetric sensitivity and over the post-irradiation diffusion of species was studied. One of the acrylic acid groups of the itaconic acid molecule was modified to obtain molecules with similar reactivity but different molecular sizes. Dosimetric systems with these modified species were irradiated in an x-ray tomograph at different doses up to 173 Gy, and the results were characterized by Raman spectroscopy and optical absorbance in order to study their feasibility and capabilities as dosimetric systems, and by optical-CT to analyze the post irradiation diffusion.
Fil: Mattea, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Romero, Marcelo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Quiroga, Andrés Agustin Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
Polymer Gel
Dosimetry
Radiotherapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15834
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Molecular structure effects on the post irradiation diffusion in polymer gel dosimetersMattea, FacundoRomero, Marcelo RicardoVedelago, José AlbertoQuiroga, Andrés Agustin IgnacioValente, Mauro AndresStrumia, Miriam CristinaPolymer GelDosimetryRadiotherapyhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Polymer gel dosimeters have specific advantages for recording 3D radiation dose distribution in diagnostic and therapeutic medical applications. A novel system based on itaconic acid and N,N?-methylene-bisacrylamide (BIS) is hereby proposed. The radical polymerization and gel formation of these monomers have been previously studied in the synthesis of a hydrogel for non dosimetric applications. Although the 3D structure of irradiated polymeric dosimeters is usually maintained for long periods of time, it is not possible to eliminate the diffusion of the different species in the regions of dose gradients within the gel. As a consequence the dose information loose quality over time. The mobility within the gelatin structure of the already mentioned species is related to their chemical structure, and nature. In this work the effect of changes in the chemical structure of the monomers over the dosimetric sensitivity and over the post-irradiation diffusion of species was studied. One of the acrylic acid groups of the itaconic acid molecule was modified to obtain molecules with similar reactivity but different molecular sizes. Dosimetric systems with these modified species were irradiated in an x-ray tomograph at different doses up to 173 Gy, and the results were characterized by Raman spectroscopy and optical absorbance in order to study their feasibility and capabilities as dosimetric systems, and by optical-CT to analyze the post irradiation diffusion.Fil: Mattea, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Romero, Marcelo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Quiroga, Andrés Agustin Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; ArgentinaFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaElsevier2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15834Mattea, Facundo; Romero, Marcelo Ricardo; Vedelago, José Alberto; Quiroga, Andrés Agustin Ignacio; Valente, Mauro Andres; et al.; Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters; Elsevier; Applied Radiation And Isotopes; 100; 6-2015; 101-1070969-8043enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969804315000779info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2015.03.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:54Zoai:ri.conicet.gov.ar:11336/15834instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:54.796CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
title Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
spellingShingle Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
Mattea, Facundo
Polymer Gel
Dosimetry
Radiotherapy
title_short Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
title_full Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
title_fullStr Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
title_full_unstemmed Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
title_sort Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters
dc.creator.none.fl_str_mv Mattea, Facundo
Romero, Marcelo Ricardo
Vedelago, José Alberto
Quiroga, Andrés Agustin Ignacio
Valente, Mauro Andres
Strumia, Miriam Cristina
author Mattea, Facundo
author_facet Mattea, Facundo
Romero, Marcelo Ricardo
Vedelago, José Alberto
Quiroga, Andrés Agustin Ignacio
Valente, Mauro Andres
Strumia, Miriam Cristina
author_role author
author2 Romero, Marcelo Ricardo
Vedelago, José Alberto
Quiroga, Andrés Agustin Ignacio
Valente, Mauro Andres
Strumia, Miriam Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Polymer Gel
Dosimetry
Radiotherapy
topic Polymer Gel
Dosimetry
Radiotherapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Polymer gel dosimeters have specific advantages for recording 3D radiation dose distribution in diagnostic and therapeutic medical applications. A novel system based on itaconic acid and N,N?-methylene-bisacrylamide (BIS) is hereby proposed. The radical polymerization and gel formation of these monomers have been previously studied in the synthesis of a hydrogel for non dosimetric applications. Although the 3D structure of irradiated polymeric dosimeters is usually maintained for long periods of time, it is not possible to eliminate the diffusion of the different species in the regions of dose gradients within the gel. As a consequence the dose information loose quality over time. The mobility within the gelatin structure of the already mentioned species is related to their chemical structure, and nature. In this work the effect of changes in the chemical structure of the monomers over the dosimetric sensitivity and over the post-irradiation diffusion of species was studied. One of the acrylic acid groups of the itaconic acid molecule was modified to obtain molecules with similar reactivity but different molecular sizes. Dosimetric systems with these modified species were irradiated in an x-ray tomograph at different doses up to 173 Gy, and the results were characterized by Raman spectroscopy and optical absorbance in order to study their feasibility and capabilities as dosimetric systems, and by optical-CT to analyze the post irradiation diffusion.
Fil: Mattea, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Romero, Marcelo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Quiroga, Andrés Agustin Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description Polymer gel dosimeters have specific advantages for recording 3D radiation dose distribution in diagnostic and therapeutic medical applications. A novel system based on itaconic acid and N,N?-methylene-bisacrylamide (BIS) is hereby proposed. The radical polymerization and gel formation of these monomers have been previously studied in the synthesis of a hydrogel for non dosimetric applications. Although the 3D structure of irradiated polymeric dosimeters is usually maintained for long periods of time, it is not possible to eliminate the diffusion of the different species in the regions of dose gradients within the gel. As a consequence the dose information loose quality over time. The mobility within the gelatin structure of the already mentioned species is related to their chemical structure, and nature. In this work the effect of changes in the chemical structure of the monomers over the dosimetric sensitivity and over the post-irradiation diffusion of species was studied. One of the acrylic acid groups of the itaconic acid molecule was modified to obtain molecules with similar reactivity but different molecular sizes. Dosimetric systems with these modified species were irradiated in an x-ray tomograph at different doses up to 173 Gy, and the results were characterized by Raman spectroscopy and optical absorbance in order to study their feasibility and capabilities as dosimetric systems, and by optical-CT to analyze the post irradiation diffusion.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15834
Mattea, Facundo; Romero, Marcelo Ricardo; Vedelago, José Alberto; Quiroga, Andrés Agustin Ignacio; Valente, Mauro Andres; et al.; Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters; Elsevier; Applied Radiation And Isotopes; 100; 6-2015; 101-107
0969-8043
url http://hdl.handle.net/11336/15834
identifier_str_mv Mattea, Facundo; Romero, Marcelo Ricardo; Vedelago, José Alberto; Quiroga, Andrés Agustin Ignacio; Valente, Mauro Andres; et al.; Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters; Elsevier; Applied Radiation And Isotopes; 100; 6-2015; 101-107
0969-8043
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969804315000779
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2015.03.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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