Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys

Autores
Hirschler, Valeria; Meroño, Tomás; Maccallini, Gustavo; Gomez Rosso, Leonardo Adrián; Aranda, Claudio; Brites, Fernando Daniel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and Aims Cholesteryl ester transfer protein (CETP) has been proposed to be associated with high risk of cardiovascular disease. Increased CETP activity was previously reported in obese adults, although its association with lifestyle behaviors has not been assessed in healthy adolescents. We undertook this study to determine the association between CETP activity and overweight/obesity, insulin resistance markers, components of the metabolic syndrome and lifestyle behaviors in healthy adolescent males. Methods Data were collected from 164 adolescents from an amateur rugby club. Body mass index (BMI), blood pressure (BP), Tanner stages, lipids, glucose, insulin and CETP activity were measured. Questionnaires for daily intake of breakfast, sweet drinks, milk, and hours of TV watching were completed. Results About 26% of the adolescents were obese and 23% overweight. The prevalence of metabolic syndrome was 6.7%. CETP activity was higher in obese than in normal and overweight adolescents (174 ± 35, 141 ± 30, and 149 ± 38%/ml/min, respectively; p <0.001). Univariate correlations showed an inverse association between CETP and HDL-C (r = −0.43; p = 0.018) and positive ones with BMI (r = 0.38; p = 0.007), systolic BP (r = 0.20; p <0.01) triglycerides (r = 0.40; p = 0.001), LDL-C (r = 0.46; p <0.001), TV watching >2 h/day (r = 0.17; p 0.02), and milk intake >3 glasses/day (r = 0.16; p = 0.03). Multivariate analysis showed that triglycerides, LDL-C, HDL-C, TV watching >2 h/day, milk intake >3 glasses/day and BMI were significant independent predictors for CETP (R2 = 0.41). Conclusions Unhealthy lifestyle habits such as TV watching >2 h daily and milk intake higher than three glasses per day and the increase in BMI were shown to be closely associated with high CETP activity in apparently healthy adolescent males. Future longitudinal studies should be performed to confirm these findings.
Fil: Hirschler, Valeria. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Maccallini, Gustavo. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Aranda, Claudio. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
Obesity
Adolescent Boys
Cholesteryl Ester Transfer Protein
Cardiovascular Diseasse
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12887
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12887
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boysHirschler, ValeriaMeroño, TomásMaccallini, GustavoGomez Rosso, Leonardo AdriánAranda, ClaudioBrites, Fernando DanielObesityAdolescent BoysCholesteryl Ester Transfer ProteinCardiovascular Diseassehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background and Aims Cholesteryl ester transfer protein (CETP) has been proposed to be associated with high risk of cardiovascular disease. Increased CETP activity was previously reported in obese adults, although its association with lifestyle behaviors has not been assessed in healthy adolescents. We undertook this study to determine the association between CETP activity and overweight/obesity, insulin resistance markers, components of the metabolic syndrome and lifestyle behaviors in healthy adolescent males. Methods Data were collected from 164 adolescents from an amateur rugby club. Body mass index (BMI), blood pressure (BP), Tanner stages, lipids, glucose, insulin and CETP activity were measured. Questionnaires for daily intake of breakfast, sweet drinks, milk, and hours of TV watching were completed. Results About 26% of the adolescents were obese and 23% overweight. The prevalence of metabolic syndrome was 6.7%. CETP activity was higher in obese than in normal and overweight adolescents (174 ± 35, 141 ± 30, and 149 ± 38%/ml/min, respectively; p <0.001). Univariate correlations showed an inverse association between CETP and HDL-C (r = −0.43; p = 0.018) and positive ones with BMI (r = 0.38; p = 0.007), systolic BP (r = 0.20; p <0.01) triglycerides (r = 0.40; p = 0.001), LDL-C (r = 0.46; p <0.001), TV watching >2 h/day (r = 0.17; p 0.02), and milk intake >3 glasses/day (r = 0.16; p = 0.03). Multivariate analysis showed that triglycerides, LDL-C, HDL-C, TV watching >2 h/day, milk intake >3 glasses/day and BMI were significant independent predictors for CETP (R2 = 0.41). Conclusions Unhealthy lifestyle habits such as TV watching >2 h daily and milk intake higher than three glasses per day and the increase in BMI were shown to be closely associated with high CETP activity in apparently healthy adolescent males. Future longitudinal studies should be performed to confirm these findings.Fil: Hirschler, Valeria. Hospital General de Agudos "Carlos G. Durand"; ArgentinaFil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Maccallini, Gustavo. Hospital General de Agudos "Carlos G. Durand"; ArgentinaFil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Aranda, Claudio. Hospital General de Agudos "Carlos G. Durand"; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaInstituto Mexicano del Seguro Social2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12887Hirschler, Valeria; Meroño, Tomás; Maccallini, Gustavo; Gomez Rosso, Leonardo Adrián; Aranda, Claudio; et al.; Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys; Instituto Mexicano del Seguro Social; Archives Of Medical Research (eletronico); 42; 1; 1-2011; 53-590188-4409enginfo:eu-repo/semantics/altIdentifier/url/http://www.arcmedres.com/article/S0188-4409(10)00347-4/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.arcmed.2010.11.009info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0188440910003474info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:05Zoai:ri.conicet.gov.ar:11336/12887instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:06.078CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
title Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
spellingShingle Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
Hirschler, Valeria
Obesity
Adolescent Boys
Cholesteryl Ester Transfer Protein
Cardiovascular Diseasse
title_short Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
title_full Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
title_fullStr Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
title_full_unstemmed Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
title_sort Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys
dc.creator.none.fl_str_mv Hirschler, Valeria
Meroño, Tomás
Maccallini, Gustavo
Gomez Rosso, Leonardo Adrián
Aranda, Claudio
Brites, Fernando Daniel
author Hirschler, Valeria
author_facet Hirschler, Valeria
Meroño, Tomás
Maccallini, Gustavo
Gomez Rosso, Leonardo Adrián
Aranda, Claudio
Brites, Fernando Daniel
author_role author
author2 Meroño, Tomás
Maccallini, Gustavo
Gomez Rosso, Leonardo Adrián
Aranda, Claudio
Brites, Fernando Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Obesity
Adolescent Boys
Cholesteryl Ester Transfer Protein
Cardiovascular Diseasse
topic Obesity
Adolescent Boys
Cholesteryl Ester Transfer Protein
Cardiovascular Diseasse
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and Aims Cholesteryl ester transfer protein (CETP) has been proposed to be associated with high risk of cardiovascular disease. Increased CETP activity was previously reported in obese adults, although its association with lifestyle behaviors has not been assessed in healthy adolescents. We undertook this study to determine the association between CETP activity and overweight/obesity, insulin resistance markers, components of the metabolic syndrome and lifestyle behaviors in healthy adolescent males. Methods Data were collected from 164 adolescents from an amateur rugby club. Body mass index (BMI), blood pressure (BP), Tanner stages, lipids, glucose, insulin and CETP activity were measured. Questionnaires for daily intake of breakfast, sweet drinks, milk, and hours of TV watching were completed. Results About 26% of the adolescents were obese and 23% overweight. The prevalence of metabolic syndrome was 6.7%. CETP activity was higher in obese than in normal and overweight adolescents (174 ± 35, 141 ± 30, and 149 ± 38%/ml/min, respectively; p <0.001). Univariate correlations showed an inverse association between CETP and HDL-C (r = −0.43; p = 0.018) and positive ones with BMI (r = 0.38; p = 0.007), systolic BP (r = 0.20; p <0.01) triglycerides (r = 0.40; p = 0.001), LDL-C (r = 0.46; p <0.001), TV watching >2 h/day (r = 0.17; p 0.02), and milk intake >3 glasses/day (r = 0.16; p = 0.03). Multivariate analysis showed that triglycerides, LDL-C, HDL-C, TV watching >2 h/day, milk intake >3 glasses/day and BMI were significant independent predictors for CETP (R2 = 0.41). Conclusions Unhealthy lifestyle habits such as TV watching >2 h daily and milk intake higher than three glasses per day and the increase in BMI were shown to be closely associated with high CETP activity in apparently healthy adolescent males. Future longitudinal studies should be performed to confirm these findings.
Fil: Hirschler, Valeria. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Maccallini, Gustavo. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Aranda, Claudio. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Background and Aims Cholesteryl ester transfer protein (CETP) has been proposed to be associated with high risk of cardiovascular disease. Increased CETP activity was previously reported in obese adults, although its association with lifestyle behaviors has not been assessed in healthy adolescents. We undertook this study to determine the association between CETP activity and overweight/obesity, insulin resistance markers, components of the metabolic syndrome and lifestyle behaviors in healthy adolescent males. Methods Data were collected from 164 adolescents from an amateur rugby club. Body mass index (BMI), blood pressure (BP), Tanner stages, lipids, glucose, insulin and CETP activity were measured. Questionnaires for daily intake of breakfast, sweet drinks, milk, and hours of TV watching were completed. Results About 26% of the adolescents were obese and 23% overweight. The prevalence of metabolic syndrome was 6.7%. CETP activity was higher in obese than in normal and overweight adolescents (174 ± 35, 141 ± 30, and 149 ± 38%/ml/min, respectively; p <0.001). Univariate correlations showed an inverse association between CETP and HDL-C (r = −0.43; p = 0.018) and positive ones with BMI (r = 0.38; p = 0.007), systolic BP (r = 0.20; p <0.01) triglycerides (r = 0.40; p = 0.001), LDL-C (r = 0.46; p <0.001), TV watching >2 h/day (r = 0.17; p 0.02), and milk intake >3 glasses/day (r = 0.16; p = 0.03). Multivariate analysis showed that triglycerides, LDL-C, HDL-C, TV watching >2 h/day, milk intake >3 glasses/day and BMI were significant independent predictors for CETP (R2 = 0.41). Conclusions Unhealthy lifestyle habits such as TV watching >2 h daily and milk intake higher than three glasses per day and the increase in BMI were shown to be closely associated with high CETP activity in apparently healthy adolescent males. Future longitudinal studies should be performed to confirm these findings.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12887
Hirschler, Valeria; Meroño, Tomás; Maccallini, Gustavo; Gomez Rosso, Leonardo Adrián; Aranda, Claudio; et al.; Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys; Instituto Mexicano del Seguro Social; Archives Of Medical Research (eletronico); 42; 1; 1-2011; 53-59
0188-4409
url http://hdl.handle.net/11336/12887
identifier_str_mv Hirschler, Valeria; Meroño, Tomás; Maccallini, Gustavo; Gomez Rosso, Leonardo Adrián; Aranda, Claudio; et al.; Impact of unhealthy lifestyle behaviors and obesity on CETP among adolescent boys; Instituto Mexicano del Seguro Social; Archives Of Medical Research (eletronico); 42; 1; 1-2011; 53-59
0188-4409
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.arcmedres.com/article/S0188-4409(10)00347-4/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arcmed.2010.11.009
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0188440910003474
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto Mexicano del Seguro Social
publisher.none.fl_str_mv Instituto Mexicano del Seguro Social
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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