Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting

Autores
Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia Diana; Osuna, Carolina; Pichel, Mariana; Cassini, Marcelo Hernan; Centron, Daniela; Serratia marcescens Argentinean Collaborative Group
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Serratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.
Fil: Merkier, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Rodríguez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Togneri, Ana. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; Argentina
Fil: Brengio, Silvia Diana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Mendoza. Instituto Argentino de Investigaciones de Zonas Aridas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Osuna, Carolina. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; Argentina
Fil: Pichel, Mariana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Cassini, Marcelo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas. Grupo de Estudios en Ecología de Mamíferos; Argentina
Fil: Centron, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Serratia marcescens Argentinean Collaborative Group. No especifíca;
Materia
Serratia Marcescens
Outbreak
Colistin
Integrons
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1827
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/1827
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital settingMerkier, Andrea KarinaRodríguez, María CeciliaTogneri, AnaBrengio, Silvia DianaOsuna, CarolinaPichel, MarianaCassini, Marcelo HernanCentron, DanielaSerratia marcescens Argentinean Collaborative GroupSerratia MarcescensOutbreakColistinIntegronshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Serratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.Fil: Merkier, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Rodríguez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Togneri, Ana. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; ArgentinaFil: Brengio, Silvia Diana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Mendoza. Instituto Argentino de Investigaciones de Zonas Aridas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Osuna, Carolina. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; ArgentinaFil: Pichel, Mariana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Cassini, Marcelo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas. Grupo de Estudios en Ecología de Mamíferos; ArgentinaFil: Centron, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Serratia marcescens Argentinean Collaborative Group. No especifíca;American Society for Microbiology2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1827Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia Diana; Osuna, Carolina; et al.; Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting; American Society for Microbiology; Journal of Clinical Microbiology; 51; 7; 7-2013; 2295-23020095-11371098-660Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697717/info:eu-repo/semantics/altIdentifier/doi/doi:10.1128/JCM.03280-12info:eu-repo/semantics/altIdentifier/url/http://jcm.asm.org/content/51/7/2295.full.pdf+htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:01Zoai:ri.conicet.gov.ar:11336/1827instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:01.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
title Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
spellingShingle Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
Merkier, Andrea Karina
Serratia Marcescens
Outbreak
Colistin
Integrons
title_short Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
title_full Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
title_fullStr Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
title_full_unstemmed Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
title_sort Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
dc.creator.none.fl_str_mv Merkier, Andrea Karina
Rodríguez, María Cecilia
Togneri, Ana
Brengio, Silvia Diana
Osuna, Carolina
Pichel, Mariana
Cassini, Marcelo Hernan
Centron, Daniela
Serratia marcescens Argentinean Collaborative Group
author Merkier, Andrea Karina
author_facet Merkier, Andrea Karina
Rodríguez, María Cecilia
Togneri, Ana
Brengio, Silvia Diana
Osuna, Carolina
Pichel, Mariana
Cassini, Marcelo Hernan
Centron, Daniela
Serratia marcescens Argentinean Collaborative Group
author_role author
author2 Rodríguez, María Cecilia
Togneri, Ana
Brengio, Silvia Diana
Osuna, Carolina
Pichel, Mariana
Cassini, Marcelo Hernan
Centron, Daniela
Serratia marcescens Argentinean Collaborative Group
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Serratia Marcescens
Outbreak
Colistin
Integrons
topic Serratia Marcescens
Outbreak
Colistin
Integrons
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Serratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.
Fil: Merkier, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Rodríguez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Togneri, Ana. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; Argentina
Fil: Brengio, Silvia Diana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Mendoza. Instituto Argentino de Investigaciones de Zonas Aridas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Osuna, Carolina. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; Argentina
Fil: Pichel, Mariana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Cassini, Marcelo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas. Grupo de Estudios en Ecología de Mamíferos; Argentina
Fil: Centron, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Serratia marcescens Argentinean Collaborative Group. No especifíca;
description Serratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1827
Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia Diana; Osuna, Carolina; et al.; Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting; American Society for Microbiology; Journal of Clinical Microbiology; 51; 7; 7-2013; 2295-2302
0095-1137
1098-660X
url http://hdl.handle.net/11336/1827
identifier_str_mv Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia Diana; Osuna, Carolina; et al.; Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting; American Society for Microbiology; Journal of Clinical Microbiology; 51; 7; 7-2013; 2295-2302
0095-1137
1098-660X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697717/
info:eu-repo/semantics/altIdentifier/doi/doi:10.1128/JCM.03280-12
info:eu-repo/semantics/altIdentifier/url/http://jcm.asm.org/content/51/7/2295.full.pdf+html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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