Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection

Autores
Carbajosa, Sofía; Gea, Susana; Chillón-Marinas, Carlos; Poveda, Cristina; Maza, María del Carmen; Fresno, Manuel; Gironès, Núria
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alterations in mice infected with Trypanosoma cruzi. In addition, depletion of the DN2 stage was previous to the DN1, indicating an alteration in the differentiation from DN1 to DN2 thymocytes. Interestingly, infected mice deficient in IL-6 expression showed higher numbers of DP and CD4+ thymocytes than wild type infected mice, while presenting similar percentages of DN1 thymocytes. Moreover, the drop in late differentiation stages of DN thymocytes was partially abrogated in comparison with wild type littermates. Thus, our results suggest that thymic atrophy involves a drop in CLPs production in bone marrow and IL-6-dependent and independent mechanisms that inhibits the differentiation of DN thymocytes.
Fil: Carbajosa, Sofía. Universidad Autónoma de Madrid; España
Fil: Gea, Susana. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Chillón-Marinas, Carlos. Universidad Autónoma de Madrid; España
Fil: Poveda, Cristina. Universidad Autónoma de Madrid; España
Fil: Maza, María del Carmen. Universidad Autónoma de Madrid; España
Fil: Fresno, Manuel. Universidad Autónoma de Madrid; España
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España
Materia
TRYPANOSOMA CRUZI
IL-6
CHAGAS DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48091
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/48091
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infectionCarbajosa, SofíaGea, SusanaChillón-Marinas, CarlosPoveda, CristinaMaza, María del CarmenFresno, ManuelGironès, NúriaTRYPANOSOMA CRUZIIL-6CHAGAS DISEASEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alterations in mice infected with Trypanosoma cruzi. In addition, depletion of the DN2 stage was previous to the DN1, indicating an alteration in the differentiation from DN1 to DN2 thymocytes. Interestingly, infected mice deficient in IL-6 expression showed higher numbers of DP and CD4+ thymocytes than wild type infected mice, while presenting similar percentages of DN1 thymocytes. Moreover, the drop in late differentiation stages of DN thymocytes was partially abrogated in comparison with wild type littermates. Thus, our results suggest that thymic atrophy involves a drop in CLPs production in bone marrow and IL-6-dependent and independent mechanisms that inhibits the differentiation of DN thymocytes.Fil: Carbajosa, Sofía. Universidad Autónoma de Madrid; EspañaFil: Gea, Susana. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Chillón-Marinas, Carlos. Universidad Autónoma de Madrid; EspañaFil: Poveda, Cristina. Universidad Autónoma de Madrid; EspañaFil: Maza, María del Carmen. Universidad Autónoma de Madrid; EspañaFil: Fresno, Manuel. Universidad Autónoma de Madrid; EspañaFil: Gironès, Núria. Universidad Autónoma de Madrid; EspañaImpact Journals2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48091Carbajosa, Sofía; Gea, Susana; Chillón-Marinas, Carlos; Poveda, Cristina; Maza, María del Carmen; et al.; Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection; Impact Journals; Oncotarget; 8; 11; 1-2017; 17551-175611949-2553CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/28147332info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.14886info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:57Zoai:ri.conicet.gov.ar:11336/48091instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:58.227CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
title Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
spellingShingle Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
Carbajosa, Sofía
TRYPANOSOMA CRUZI
IL-6
CHAGAS DISEASE
title_short Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
title_full Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
title_fullStr Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
title_full_unstemmed Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
title_sort Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection
dc.creator.none.fl_str_mv Carbajosa, Sofía
Gea, Susana
Chillón-Marinas, Carlos
Poveda, Cristina
Maza, María del Carmen
Fresno, Manuel
Gironès, Núria
author Carbajosa, Sofía
author_facet Carbajosa, Sofía
Gea, Susana
Chillón-Marinas, Carlos
Poveda, Cristina
Maza, María del Carmen
Fresno, Manuel
Gironès, Núria
author_role author
author2 Gea, Susana
Chillón-Marinas, Carlos
Poveda, Cristina
Maza, María del Carmen
Fresno, Manuel
Gironès, Núria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv TRYPANOSOMA CRUZI
IL-6
CHAGAS DISEASE
topic TRYPANOSOMA CRUZI
IL-6
CHAGAS DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alterations in mice infected with Trypanosoma cruzi. In addition, depletion of the DN2 stage was previous to the DN1, indicating an alteration in the differentiation from DN1 to DN2 thymocytes. Interestingly, infected mice deficient in IL-6 expression showed higher numbers of DP and CD4+ thymocytes than wild type infected mice, while presenting similar percentages of DN1 thymocytes. Moreover, the drop in late differentiation stages of DN thymocytes was partially abrogated in comparison with wild type littermates. Thus, our results suggest that thymic atrophy involves a drop in CLPs production in bone marrow and IL-6-dependent and independent mechanisms that inhibits the differentiation of DN thymocytes.
Fil: Carbajosa, Sofía. Universidad Autónoma de Madrid; España
Fil: Gea, Susana. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Chillón-Marinas, Carlos. Universidad Autónoma de Madrid; España
Fil: Poveda, Cristina. Universidad Autónoma de Madrid; España
Fil: Maza, María del Carmen. Universidad Autónoma de Madrid; España
Fil: Fresno, Manuel. Universidad Autónoma de Madrid; España
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España
description Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alterations in mice infected with Trypanosoma cruzi. In addition, depletion of the DN2 stage was previous to the DN1, indicating an alteration in the differentiation from DN1 to DN2 thymocytes. Interestingly, infected mice deficient in IL-6 expression showed higher numbers of DP and CD4+ thymocytes than wild type infected mice, while presenting similar percentages of DN1 thymocytes. Moreover, the drop in late differentiation stages of DN thymocytes was partially abrogated in comparison with wild type littermates. Thus, our results suggest that thymic atrophy involves a drop in CLPs production in bone marrow and IL-6-dependent and independent mechanisms that inhibits the differentiation of DN thymocytes.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48091
Carbajosa, Sofía; Gea, Susana; Chillón-Marinas, Carlos; Poveda, Cristina; Maza, María del Carmen; et al.; Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection; Impact Journals; Oncotarget; 8; 11; 1-2017; 17551-17561
1949-2553
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48091
identifier_str_mv Carbajosa, Sofía; Gea, Susana; Chillón-Marinas, Carlos; Poveda, Cristina; Maza, María del Carmen; et al.; Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection; Impact Journals; Oncotarget; 8; 11; 1-2017; 17551-17561
1949-2553
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/28147332
info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.14886
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268827906211840
score 13.13397

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