Interleukin-6: A cytokine to forget

Autores
Balschun, D.; Wetzel, W.; del Rey, A.; Pitossi, Fernando Juan; Schneider, Heloisa; Zuschratter, W.; Besedovsky, H. O.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is known that proinflammatory cytokines such as interleukin-6 (IL-6) are expressed in the central nervous system (CNS) during disease conditions and affect several brain functions including memory and learning. In contrast to these effects observed during pathological conditions, here we describe a physiological function of IL-6 in the “healthy” brain in synaptic plasticity and memory consolidation. During long-term potentiation (LTP) in vitro and in freely moving rats, IL-6 gene expression in the hippocampus was substantially increased. This increase was long lasting, specific to potentiation, and was prevented by inhibition of N-methyl-Daspartate receptors with (±)-2-amino-5-phosphonopentanoic acid (AP-5). Blockade of endogenous IL-6 by application of a neutralizing anti-IL6 antibody 90 min after tetanus caused a remarkable prolongation of LTP. Consistently, blockade of endogenous IL-6, 90 min after hippocampus-dependent spatial alternation learning resulted in a significant improvement of long-term memory. In view of the suggested role of LTP in memory formation, these data implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage.
Fil: Balschun, D.. Leibniz Institute for Neurobiology; Alemania
Fil: Wetzel, W.. Leibniz Institute for Neurobiology; Alemania
Fil: del Rey, A.. Philipps University Marburg; Alemania
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schneider, Heloisa. Philipps University Marburg; Alemania
Fil: Zuschratter, W.. Leibniz Institute for Neurobiology; Alemania
Fil: Besedovsky, H. O.. Philipps University Marburg; Alemania
Materia
il-6
ltp
spatial learning
hippocampus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/101042
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interleukin-6: A cytokine to forgetBalschun, D.Wetzel, W.del Rey, A.Pitossi, Fernando JuanSchneider, HeloisaZuschratter, W.Besedovsky, H. O.il-6ltpspatial learninghippocampushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is known that proinflammatory cytokines such as interleukin-6 (IL-6) are expressed in the central nervous system (CNS) during disease conditions and affect several brain functions including memory and learning. In contrast to these effects observed during pathological conditions, here we describe a physiological function of IL-6 in the “healthy” brain in synaptic plasticity and memory consolidation. During long-term potentiation (LTP) in vitro and in freely moving rats, IL-6 gene expression in the hippocampus was substantially increased. This increase was long lasting, specific to potentiation, and was prevented by inhibition of N-methyl-Daspartate receptors with (±)-2-amino-5-phosphonopentanoic acid (AP-5). Blockade of endogenous IL-6 by application of a neutralizing anti-IL6 antibody 90 min after tetanus caused a remarkable prolongation of LTP. Consistently, blockade of endogenous IL-6, 90 min after hippocampus-dependent spatial alternation learning resulted in a significant improvement of long-term memory. In view of the suggested role of LTP in memory formation, these data implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage.Fil: Balschun, D.. Leibniz Institute for Neurobiology; AlemaniaFil: Wetzel, W.. Leibniz Institute for Neurobiology; AlemaniaFil: del Rey, A.. Philipps University Marburg; AlemaniaFil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Schneider, Heloisa. Philipps University Marburg; AlemaniaFil: Zuschratter, W.. Leibniz Institute for Neurobiology; AlemaniaFil: Besedovsky, H. O.. Philipps University Marburg; AlemaniaFederation of American Societies for Experimental Biology2004-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/101042Balschun, D.; Wetzel, W.; del Rey, A.; Pitossi, Fernando Juan; Schneider, Heloisa; et al.; Interleukin-6: A cytokine to forget; Federation of American Societies for Experimental Biology; FASEB Journal; 18; 14; 9-2004; 1788-17900892-66381530-6860CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/abs/10.1096/fj.04-1625fjeinfo:eu-repo/semantics/altIdentifier/doi/10.1096/fj.04-1625fjeinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:53:30Zoai:ri.conicet.gov.ar:11336/101042instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:53:30.857CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interleukin-6: A cytokine to forget
title Interleukin-6: A cytokine to forget
spellingShingle Interleukin-6: A cytokine to forget
Balschun, D.
il-6
ltp
spatial learning
hippocampus
title_short Interleukin-6: A cytokine to forget
title_full Interleukin-6: A cytokine to forget
title_fullStr Interleukin-6: A cytokine to forget
title_full_unstemmed Interleukin-6: A cytokine to forget
title_sort Interleukin-6: A cytokine to forget
dc.creator.none.fl_str_mv Balschun, D.
Wetzel, W.
del Rey, A.
Pitossi, Fernando Juan
Schneider, Heloisa
Zuschratter, W.
Besedovsky, H. O.
author Balschun, D.
author_facet Balschun, D.
Wetzel, W.
del Rey, A.
Pitossi, Fernando Juan
Schneider, Heloisa
Zuschratter, W.
Besedovsky, H. O.
author_role author
author2 Wetzel, W.
del Rey, A.
Pitossi, Fernando Juan
Schneider, Heloisa
Zuschratter, W.
Besedovsky, H. O.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv il-6
ltp
spatial learning
hippocampus
topic il-6
ltp
spatial learning
hippocampus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is known that proinflammatory cytokines such as interleukin-6 (IL-6) are expressed in the central nervous system (CNS) during disease conditions and affect several brain functions including memory and learning. In contrast to these effects observed during pathological conditions, here we describe a physiological function of IL-6 in the “healthy” brain in synaptic plasticity and memory consolidation. During long-term potentiation (LTP) in vitro and in freely moving rats, IL-6 gene expression in the hippocampus was substantially increased. This increase was long lasting, specific to potentiation, and was prevented by inhibition of N-methyl-Daspartate receptors with (±)-2-amino-5-phosphonopentanoic acid (AP-5). Blockade of endogenous IL-6 by application of a neutralizing anti-IL6 antibody 90 min after tetanus caused a remarkable prolongation of LTP. Consistently, blockade of endogenous IL-6, 90 min after hippocampus-dependent spatial alternation learning resulted in a significant improvement of long-term memory. In view of the suggested role of LTP in memory formation, these data implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage.
Fil: Balschun, D.. Leibniz Institute for Neurobiology; Alemania
Fil: Wetzel, W.. Leibniz Institute for Neurobiology; Alemania
Fil: del Rey, A.. Philipps University Marburg; Alemania
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schneider, Heloisa. Philipps University Marburg; Alemania
Fil: Zuschratter, W.. Leibniz Institute for Neurobiology; Alemania
Fil: Besedovsky, H. O.. Philipps University Marburg; Alemania
description It is known that proinflammatory cytokines such as interleukin-6 (IL-6) are expressed in the central nervous system (CNS) during disease conditions and affect several brain functions including memory and learning. In contrast to these effects observed during pathological conditions, here we describe a physiological function of IL-6 in the “healthy” brain in synaptic plasticity and memory consolidation. During long-term potentiation (LTP) in vitro and in freely moving rats, IL-6 gene expression in the hippocampus was substantially increased. This increase was long lasting, specific to potentiation, and was prevented by inhibition of N-methyl-Daspartate receptors with (±)-2-amino-5-phosphonopentanoic acid (AP-5). Blockade of endogenous IL-6 by application of a neutralizing anti-IL6 antibody 90 min after tetanus caused a remarkable prolongation of LTP. Consistently, blockade of endogenous IL-6, 90 min after hippocampus-dependent spatial alternation learning resulted in a significant improvement of long-term memory. In view of the suggested role of LTP in memory formation, these data implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage.
publishDate 2004
dc.date.none.fl_str_mv 2004-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/101042
Balschun, D.; Wetzel, W.; del Rey, A.; Pitossi, Fernando Juan; Schneider, Heloisa; et al.; Interleukin-6: A cytokine to forget; Federation of American Societies for Experimental Biology; FASEB Journal; 18; 14; 9-2004; 1788-1790
0892-6638
1530-6860
CONICET Digital
CONICET
url http://hdl.handle.net/11336/101042
identifier_str_mv Balschun, D.; Wetzel, W.; del Rey, A.; Pitossi, Fernando Juan; Schneider, Heloisa; et al.; Interleukin-6: A cytokine to forget; Federation of American Societies for Experimental Biology; FASEB Journal; 18; 14; 9-2004; 1788-1790
0892-6638
1530-6860
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/abs/10.1096/fj.04-1625fje
info:eu-repo/semantics/altIdentifier/doi/10.1096/fj.04-1625fje
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083065965707264
score 13.22299

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