The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Autores: Mallick, Swapan; Li, Heng; Lipson, Mark; Mathieson, Iain; Gymrek, Melissa; Racimo, Fernando; Zhao, Mengyao; Chennagiri, Niru; Nordenfelt, Susanne; Tandon, Arti; Skoglund, Pontus; Lazaridis, Iosif; Sankararaman, Sriram; Fu, Qiaomei; Rohland, Nadin; Renaud, Gabriel; Erlich, Yaniv; Willems, Thomas; Gallo, Carla; Spence, Jeffrey P.; Song, Yun S.; Poletti, Giovanni; Balloux, Francois; van Driem, George; Knijff, Peter de; Gallego Romero, Irene; Jha, Aashish R.; Behar, Doron M.; Bravi, Claudio Marcelo; Capelli, Cristian
Año de publicación: 2016
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: We report the Simons Genome Diversity Project (SGDP) dataset: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioral modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that in other non-Africans.
Fil: Mallick, Swapan. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos
Fil: Li, Heng. Broad Institute Of Harvard And Mit; Estados Unidos
Fil: Lipson, Mark. Harvard Medical School; Estados Unidos
Fil: Mathieson, Iain. Harvard Medical School; Estados Unidos
Fil: Gymrek, Melissa. Broad Institute Of Harvard And Mit; Estados Unidos. Whitehead Institute For Biomedical Research; Estados Unidos
Fil: Racimo, Fernando. Department Of Integrative Biology; Estados Unidos
Fil: Zhao, Mengyao. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Chennagiri, Niru. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Nordenfelt, Susanne. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos
Fil: Tandon, Arti. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos
Fil: Skoglund, Pontus. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Lazaridis, Iosif. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Sankararaman, Sriram. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Fu, Qiaomei. Key Laboratory Of Vertebrate Evolution And Human Origin; China. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Rohland, Nadin. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos
Fil: Renaud, Gabriel. Max Planck Institute For Evolutionary Anthropology; Alemania
Fil: Erlich, Yaniv. New York Genome Center; Estados Unidos
Fil: Willems, Thomas. Massachusetts Institute of Technology; Estados Unidos
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Spence, Jeffrey P.. University of California at Berkeley; Estados Unidos
Fil: Song, Yun S.. University of California at Berkeley; Estados Unidos
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Balloux, Francois. University College London; Estados Unidos
Fil: van Driem, George. University Of Bern; Suiza
Fil: Knijff, Peter de. Leiden University Medical Center; Países Bajos
Fil: Gallego Romero, Irene. Nanyang Technological University; Singapur
Fil: Jha, Aashish R.. University of Chicago; Estados Unidos
Fil: Behar, Doron M.. Estonian Biocentre, Evolutionary Biology Group; Estonia
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Capelli, Cristian. University of Oxford; Reino Unido
Materia: Simons Genome Diversity Project
HUMAN ORIGINS
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/125570

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spelling	The Simons Genome Diversity Project: 300 genomes from 142 diverse populationsMallick, SwapanLi, HengLipson, MarkMathieson, IainGymrek, MelissaRacimo, FernandoZhao, MengyaoChennagiri, NiruNordenfelt, SusanneTandon, ArtiSkoglund, PontusLazaridis, IosifSankararaman, SriramFu, QiaomeiRohland, NadinRenaud, GabrielErlich, YanivWillems, ThomasGallo, CarlaSpence, Jeffrey P.Song, Yun S.Poletti, GiovanniBalloux, Francoisvan Driem, GeorgeKnijff, Peter deGallego Romero, IreneJha, Aashish R.Behar, Doron M.Bravi, Claudio MarceloCapelli, CristianSimons Genome Diversity ProjectHUMAN ORIGINShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We report the Simons Genome Diversity Project (SGDP) dataset: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioral modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that in other non-Africans.Fil: Mallick, Swapan. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados UnidosFil: Li, Heng. Broad Institute Of Harvard And Mit; Estados UnidosFil: Lipson, Mark. Harvard Medical School; Estados UnidosFil: Mathieson, Iain. Harvard Medical School; Estados UnidosFil: Gymrek, Melissa. Broad Institute Of Harvard And Mit; Estados Unidos. Whitehead Institute For Biomedical Research; Estados UnidosFil: Racimo, Fernando. Department Of Integrative Biology; Estados UnidosFil: Zhao, Mengyao. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados UnidosFil: Chennagiri, Niru. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados UnidosFil: Nordenfelt, Susanne. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados UnidosFil: Tandon, Arti. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados UnidosFil: Skoglund, Pontus. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados UnidosFil: Lazaridis, Iosif. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados UnidosFil: Sankararaman, Sriram. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados UnidosFil: Fu, Qiaomei. Key Laboratory Of Vertebrate Evolution And Human Origin; China. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados UnidosFil: Rohland, Nadin. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados UnidosFil: Renaud, Gabriel. Max Planck Institute For Evolutionary Anthropology; AlemaniaFil: Erlich, Yaniv. New York Genome Center; Estados UnidosFil: Willems, Thomas. Massachusetts Institute of Technology; Estados UnidosFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Spence, Jeffrey P.. University of California at Berkeley; Estados UnidosFil: Song, Yun S.. University of California at Berkeley; Estados UnidosFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Balloux, Francois. University College London; Estados UnidosFil: van Driem, George. University Of Bern; SuizaFil: Knijff, Peter de. Leiden University Medical Center; Países BajosFil: Gallego Romero, Irene. Nanyang Technological University; SingapurFil: Jha, Aashish R.. University of Chicago; Estados UnidosFil: Behar, Doron M.. Estonian Biocentre, Evolutionary Biology Group; EstoniaFil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Capelli, Cristian. University of Oxford; Reino UnidoNature Publishing Group2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125570Mallick, Swapan; Li, Heng; Lipson, Mark; Mathieson, Iain; Gymrek, Melissa; et al.; The Simons Genome Diversity Project: 300 genomes from 142 diverse populations; Nature Publishing Group; Nature; 538; 10-2016; 201-2060028-0836CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v538/n7624/full/nature18964.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nature18964info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161557/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:02Zoai:ri.conicet.gov.ar:11336/125570instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:02.758CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
title	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
spellingShingle	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations Mallick, Swapan Simons Genome Diversity Project HUMAN ORIGINS
title_short	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
title_full	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
title_fullStr	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
title_full_unstemmed	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
title_sort	The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
dc.creator.none.fl_str_mv	Mallick, Swapan Li, Heng Lipson, Mark Mathieson, Iain Gymrek, Melissa Racimo, Fernando Zhao, Mengyao Chennagiri, Niru Nordenfelt, Susanne Tandon, Arti Skoglund, Pontus Lazaridis, Iosif Sankararaman, Sriram Fu, Qiaomei Rohland, Nadin Renaud, Gabriel Erlich, Yaniv Willems, Thomas Gallo, Carla Spence, Jeffrey P. Song, Yun S. Poletti, Giovanni Balloux, Francois van Driem, George Knijff, Peter de Gallego Romero, Irene Jha, Aashish R. Behar, Doron M. Bravi, Claudio Marcelo Capelli, Cristian
author	Mallick, Swapan
author_facet	Mallick, Swapan Li, Heng Lipson, Mark Mathieson, Iain Gymrek, Melissa Racimo, Fernando Zhao, Mengyao Chennagiri, Niru Nordenfelt, Susanne Tandon, Arti Skoglund, Pontus Lazaridis, Iosif Sankararaman, Sriram Fu, Qiaomei Rohland, Nadin Renaud, Gabriel Erlich, Yaniv Willems, Thomas Gallo, Carla Spence, Jeffrey P. Song, Yun S. Poletti, Giovanni Balloux, Francois van Driem, George Knijff, Peter de Gallego Romero, Irene Jha, Aashish R. Behar, Doron M. Bravi, Claudio Marcelo Capelli, Cristian
author_role	author
author2	Li, Heng Lipson, Mark Mathieson, Iain Gymrek, Melissa Racimo, Fernando Zhao, Mengyao Chennagiri, Niru Nordenfelt, Susanne Tandon, Arti Skoglund, Pontus Lazaridis, Iosif Sankararaman, Sriram Fu, Qiaomei Rohland, Nadin Renaud, Gabriel Erlich, Yaniv Willems, Thomas Gallo, Carla Spence, Jeffrey P. Song, Yun S. Poletti, Giovanni Balloux, Francois van Driem, George Knijff, Peter de Gallego Romero, Irene Jha, Aashish R. Behar, Doron M. Bravi, Claudio Marcelo Capelli, Cristian
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Simons Genome Diversity Project HUMAN ORIGINS
topic	Simons Genome Diversity Project HUMAN ORIGINS
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	We report the Simons Genome Diversity Project (SGDP) dataset: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioral modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that in other non-Africans. Fil: Mallick, Swapan. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos Fil: Li, Heng. Broad Institute Of Harvard And Mit; Estados Unidos Fil: Lipson, Mark. Harvard Medical School; Estados Unidos Fil: Mathieson, Iain. Harvard Medical School; Estados Unidos Fil: Gymrek, Melissa. Broad Institute Of Harvard And Mit; Estados Unidos. Whitehead Institute For Biomedical Research; Estados Unidos Fil: Racimo, Fernando. Department Of Integrative Biology; Estados Unidos Fil: Zhao, Mengyao. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos Fil: Chennagiri, Niru. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos Fil: Nordenfelt, Susanne. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos Fil: Tandon, Arti. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos Fil: Skoglund, Pontus. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos Fil: Lazaridis, Iosif. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos Fil: Sankararaman, Sriram. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos Fil: Fu, Qiaomei. Key Laboratory Of Vertebrate Evolution And Human Origin; China. Broad Institute Of Harvard And Mit; Estados Unidos. Harvard Medical School; Estados Unidos Fil: Rohland, Nadin. Harvard Medical School; Estados Unidos. Broad Institute Of Harvard And Mit; Estados Unidos Fil: Renaud, Gabriel. Max Planck Institute For Evolutionary Anthropology; Alemania Fil: Erlich, Yaniv. New York Genome Center; Estados Unidos Fil: Willems, Thomas. Massachusetts Institute of Technology; Estados Unidos Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Spence, Jeffrey P.. University of California at Berkeley; Estados Unidos Fil: Song, Yun S.. University of California at Berkeley; Estados Unidos Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú Fil: Balloux, Francois. University College London; Estados Unidos Fil: van Driem, George. University Of Bern; Suiza Fil: Knijff, Peter de. Leiden University Medical Center; Países Bajos Fil: Gallego Romero, Irene. Nanyang Technological University; Singapur Fil: Jha, Aashish R.. University of Chicago; Estados Unidos Fil: Behar, Doron M.. Estonian Biocentre, Evolutionary Biology Group; Estonia Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Capelli, Cristian. University of Oxford; Reino Unido
description	We report the Simons Genome Diversity Project (SGDP) dataset: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioral modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that in other non-Africans.
publishDate	2016
dc.date.none.fl_str_mv	2016-10
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/125570 Mallick, Swapan; Li, Heng; Lipson, Mark; Mathieson, Iain; Gymrek, Melissa; et al.; The Simons Genome Diversity Project: 300 genomes from 142 diverse populations; Nature Publishing Group; Nature; 538; 10-2016; 201-206 0028-0836 CONICET Digital CONICET
url	http://hdl.handle.net/11336/125570
identifier_str_mv	Mallick, Swapan; Li, Heng; Lipson, Mark; Mathieson, Iain; Gymrek, Melissa; et al.; The Simons Genome Diversity Project: 300 genomes from 142 diverse populations; Nature Publishing Group; Nature; 538; 10-2016; 201-206 0028-0836 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v538/n7624/full/nature18964.html info:eu-repo/semantics/altIdentifier/doi/10.1038/nature18964 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161557/
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dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

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