Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

Autores
Scott, Michael M.; Perello, Mario; Chuang, Jen Chieh; Sakata, Ichiro; Gautron, Laurent; Lee, Charlotte E.; Lauzon, Danielle; Elmquist, Joel K.; Zigman, Jeffrey M.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.
Fil: Scott, Michael M.. University of Texas; Estados Unidos. University of Virginia; Estados Unidos
Fil: Perello, Mario. University of Texas; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chuang, Jen Chieh. University of Texas; Estados Unidos
Fil: Sakata, Ichiro. University of Texas; Estados Unidos
Fil: Gautron, Laurent. University of Texas; Estados Unidos
Fil: Lee, Charlotte E.. University of Texas; Estados Unidos
Fil: Lauzon, Danielle. University of Texas; Estados Unidos
Fil: Elmquist, Joel K.. University of Texas; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas; Estados Unidos
Materia
OBESITY
HINDBRAIN
GLUCOSE HOMEOSTASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/70808
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting GlucoseScott, Michael M.Perello, MarioChuang, Jen ChiehSakata, IchiroGautron, LaurentLee, Charlotte E.Lauzon, DanielleElmquist, Joel K.Zigman, Jeffrey M.OBESITYHINDBRAINGLUCOSE HOMEOSTASIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.Fil: Scott, Michael M.. University of Texas; Estados Unidos. University of Virginia; Estados UnidosFil: Perello, Mario. University of Texas; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chuang, Jen Chieh. University of Texas; Estados UnidosFil: Sakata, Ichiro. University of Texas; Estados UnidosFil: Gautron, Laurent. University of Texas; Estados UnidosFil: Lee, Charlotte E.. University of Texas; Estados UnidosFil: Lauzon, Danielle. University of Texas; Estados UnidosFil: Elmquist, Joel K.. University of Texas; Estados UnidosFil: Zigman, Jeffrey M.. University of Texas; Estados UnidosPublic Library of Science2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70808Scott, Michael M.; Perello, Mario; Chuang, Jen Chieh; Sakata, Ichiro; Gautron, Laurent; et al.; Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose; Public Library of Science; Plos One; 7; 8; 8-2012; 1-6; e440891932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0044089info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044089info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:21Zoai:ri.conicet.gov.ar:11336/70808instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:21.436CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
title Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
spellingShingle Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
Scott, Michael M.
OBESITY
HINDBRAIN
GLUCOSE HOMEOSTASIS
title_short Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
title_full Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
title_fullStr Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
title_full_unstemmed Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
title_sort Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
dc.creator.none.fl_str_mv Scott, Michael M.
Perello, Mario
Chuang, Jen Chieh
Sakata, Ichiro
Gautron, Laurent
Lee, Charlotte E.
Lauzon, Danielle
Elmquist, Joel K.
Zigman, Jeffrey M.
author Scott, Michael M.
author_facet Scott, Michael M.
Perello, Mario
Chuang, Jen Chieh
Sakata, Ichiro
Gautron, Laurent
Lee, Charlotte E.
Lauzon, Danielle
Elmquist, Joel K.
Zigman, Jeffrey M.
author_role author
author2 Perello, Mario
Chuang, Jen Chieh
Sakata, Ichiro
Gautron, Laurent
Lee, Charlotte E.
Lauzon, Danielle
Elmquist, Joel K.
Zigman, Jeffrey M.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv OBESITY
HINDBRAIN
GLUCOSE HOMEOSTASIS
topic OBESITY
HINDBRAIN
GLUCOSE HOMEOSTASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.
Fil: Scott, Michael M.. University of Texas; Estados Unidos. University of Virginia; Estados Unidos
Fil: Perello, Mario. University of Texas; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chuang, Jen Chieh. University of Texas; Estados Unidos
Fil: Sakata, Ichiro. University of Texas; Estados Unidos
Fil: Gautron, Laurent. University of Texas; Estados Unidos
Fil: Lee, Charlotte E.. University of Texas; Estados Unidos
Fil: Lauzon, Danielle. University of Texas; Estados Unidos
Fil: Elmquist, Joel K.. University of Texas; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas; Estados Unidos
description The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/70808
Scott, Michael M.; Perello, Mario; Chuang, Jen Chieh; Sakata, Ichiro; Gautron, Laurent; et al.; Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose; Public Library of Science; Plos One; 7; 8; 8-2012; 1-6; e44089
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/70808
identifier_str_mv Scott, Michael M.; Perello, Mario; Chuang, Jen Chieh; Sakata, Ichiro; Gautron, Laurent; et al.; Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose; Public Library of Science; Plos One; 7; 8; 8-2012; 1-6; e44089
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0044089
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044089
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269999885975552
score 13.13397

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