Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential
- Autores
- Aiello, Ernesto Alejandro; Casey, Joseph R.; Alvarez, Bernardo
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Regulation of intracellular pH (pHi) is often considered a ?housekeeping? function, contributing little to cardiac function. With the study published by Sirish et al7 in this issue of Circulation: Arrhythmia and Electrophysiology, a Cl-/HCO3- exchanger is revealed to have a more central role in cardiac function.Intracellular pH is an important modulator of cardiac excitation and contraction1, and adversely contributes to electrical arrhythmia2. Cardiac myocytes express a complex apparatus to regulate pHi. Cardiac muscle cytosolic pH (~7.2) is maintained by sarcolemmal ion transport proteins that move H+, OH− or HCO3− ions across the membrane3. Along with the acid extruders Na+/H+ exchanger (NHE1) and Na+/HCO3− cotransporter (NBC, electrogenic NBCe1/e2 and electroneutral NBCn1) myocytes possess Cl-/HCO3− exchangers (SLC4 family members AE1, AE2, and AE3) and Cl-/OH- exchanger (CHE, with no molecular identity) alkali extruders3. SLC26 gene family members were identified as (mouse slc26a64 and its human orthologue SLC26A65, and slc26a36) responsible for Cl-/HCO3− and Cl-/OH- at plasma membrane of heart ventricles6. The work of Sirish et al7 in this issue revealed that ablation of slc26a6, a plasma membrane Cl-/HCO3- exchange protein, results in cardiac action potential (AP) shortening, cardiomyocyte Ca2+ transient (CaT) and sarcoplasmic reticulum (SR) Ca2+ load reduction, cardiomyocyte diminution of sarcomeric shortening, and cardiomyocyte intracellular pH (pHi) elevation. Moreover, in slc26a6-/- mice these factors led to a reduction of cardiac fractional shortening and cardiac contractility responses, and alterations of cardiac conduction system, as seen in sinus bradycardia and fragmentation of the QRS electrocardiographic-recorded complex. Since slc26a6 has stoichiometry of 2 (or more) HCO3-: Cl-, its transport function is electrogenic, with significance to the cardiomyocyte membrane potential.
Fil: Aiello, Ernesto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina
Fil: Casey, Joseph R.. University Of Alberta. Faculty Of Medicine And Oral Health Sciences; Canadá
Fil: Alvarez, Bernardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina - Materia
-
Action Potentials
Ion Transport
Physiology
Sarcoplasmatic Reticulum - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/49489
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Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potentialAiello, Ernesto AlejandroCasey, Joseph R.Alvarez, BernardoAction PotentialsIon TransportPhysiologySarcoplasmatic Reticulumhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Regulation of intracellular pH (pHi) is often considered a ?housekeeping? function, contributing little to cardiac function. With the study published by Sirish et al7 in this issue of Circulation: Arrhythmia and Electrophysiology, a Cl-/HCO3- exchanger is revealed to have a more central role in cardiac function.Intracellular pH is an important modulator of cardiac excitation and contraction1, and adversely contributes to electrical arrhythmia2. Cardiac myocytes express a complex apparatus to regulate pHi. Cardiac muscle cytosolic pH (~7.2) is maintained by sarcolemmal ion transport proteins that move H+, OH− or HCO3− ions across the membrane3. Along with the acid extruders Na+/H+ exchanger (NHE1) and Na+/HCO3− cotransporter (NBC, electrogenic NBCe1/e2 and electroneutral NBCn1) myocytes possess Cl-/HCO3− exchangers (SLC4 family members AE1, AE2, and AE3) and Cl-/OH- exchanger (CHE, with no molecular identity) alkali extruders3. SLC26 gene family members were identified as (mouse slc26a64 and its human orthologue SLC26A65, and slc26a36) responsible for Cl-/HCO3− and Cl-/OH- at plasma membrane of heart ventricles6. The work of Sirish et al7 in this issue revealed that ablation of slc26a6, a plasma membrane Cl-/HCO3- exchange protein, results in cardiac action potential (AP) shortening, cardiomyocyte Ca2+ transient (CaT) and sarcoplasmic reticulum (SR) Ca2+ load reduction, cardiomyocyte diminution of sarcomeric shortening, and cardiomyocyte intracellular pH (pHi) elevation. Moreover, in slc26a6-/- mice these factors led to a reduction of cardiac fractional shortening and cardiac contractility responses, and alterations of cardiac conduction system, as seen in sinus bradycardia and fragmentation of the QRS electrocardiographic-recorded complex. Since slc26a6 has stoichiometry of 2 (or more) HCO3-: Cl-, its transport function is electrogenic, with significance to the cardiomyocyte membrane potential.Fil: Aiello, Ernesto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaFil: Casey, Joseph R.. University Of Alberta. Faculty Of Medicine And Oral Health Sciences; CanadáFil: Alvarez, Bernardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaLippincott Williams2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49489Aiello, Ernesto Alejandro; Casey, Joseph R.; Alvarez, Bernardo; Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential; Lippincott Williams; Circulation-arrhythmia And Electrophysiology; 10; 10; 10-2017; 1-31941-3149CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://circep.ahajournals.org/content/10/10/e005812.longinfo:eu-repo/semantics/altIdentifier/doi/10.1161/CIRCEP.117.005812info:eu-repo/semantics/altIdentifier/pmid/29025770info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:07Zoai:ri.conicet.gov.ar:11336/49489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:07.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
title |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
spellingShingle |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential Aiello, Ernesto Alejandro Action Potentials Ion Transport Physiology Sarcoplasmatic Reticulum |
title_short |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
title_full |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
title_fullStr |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
title_full_unstemmed |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
title_sort |
Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential |
dc.creator.none.fl_str_mv |
Aiello, Ernesto Alejandro Casey, Joseph R. Alvarez, Bernardo |
author |
Aiello, Ernesto Alejandro |
author_facet |
Aiello, Ernesto Alejandro Casey, Joseph R. Alvarez, Bernardo |
author_role |
author |
author2 |
Casey, Joseph R. Alvarez, Bernardo |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Action Potentials Ion Transport Physiology Sarcoplasmatic Reticulum |
topic |
Action Potentials Ion Transport Physiology Sarcoplasmatic Reticulum |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Regulation of intracellular pH (pHi) is often considered a ?housekeeping? function, contributing little to cardiac function. With the study published by Sirish et al7 in this issue of Circulation: Arrhythmia and Electrophysiology, a Cl-/HCO3- exchanger is revealed to have a more central role in cardiac function.Intracellular pH is an important modulator of cardiac excitation and contraction1, and adversely contributes to electrical arrhythmia2. Cardiac myocytes express a complex apparatus to regulate pHi. Cardiac muscle cytosolic pH (~7.2) is maintained by sarcolemmal ion transport proteins that move H+, OH− or HCO3− ions across the membrane3. Along with the acid extruders Na+/H+ exchanger (NHE1) and Na+/HCO3− cotransporter (NBC, electrogenic NBCe1/e2 and electroneutral NBCn1) myocytes possess Cl-/HCO3− exchangers (SLC4 family members AE1, AE2, and AE3) and Cl-/OH- exchanger (CHE, with no molecular identity) alkali extruders3. SLC26 gene family members were identified as (mouse slc26a64 and its human orthologue SLC26A65, and slc26a36) responsible for Cl-/HCO3− and Cl-/OH- at plasma membrane of heart ventricles6. The work of Sirish et al7 in this issue revealed that ablation of slc26a6, a plasma membrane Cl-/HCO3- exchange protein, results in cardiac action potential (AP) shortening, cardiomyocyte Ca2+ transient (CaT) and sarcoplasmic reticulum (SR) Ca2+ load reduction, cardiomyocyte diminution of sarcomeric shortening, and cardiomyocyte intracellular pH (pHi) elevation. Moreover, in slc26a6-/- mice these factors led to a reduction of cardiac fractional shortening and cardiac contractility responses, and alterations of cardiac conduction system, as seen in sinus bradycardia and fragmentation of the QRS electrocardiographic-recorded complex. Since slc26a6 has stoichiometry of 2 (or more) HCO3-: Cl-, its transport function is electrogenic, with significance to the cardiomyocyte membrane potential. Fil: Aiello, Ernesto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina Fil: Casey, Joseph R.. University Of Alberta. Faculty Of Medicine And Oral Health Sciences; Canadá Fil: Alvarez, Bernardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina |
description |
Regulation of intracellular pH (pHi) is often considered a ?housekeeping? function, contributing little to cardiac function. With the study published by Sirish et al7 in this issue of Circulation: Arrhythmia and Electrophysiology, a Cl-/HCO3- exchanger is revealed to have a more central role in cardiac function.Intracellular pH is an important modulator of cardiac excitation and contraction1, and adversely contributes to electrical arrhythmia2. Cardiac myocytes express a complex apparatus to regulate pHi. Cardiac muscle cytosolic pH (~7.2) is maintained by sarcolemmal ion transport proteins that move H+, OH− or HCO3− ions across the membrane3. Along with the acid extruders Na+/H+ exchanger (NHE1) and Na+/HCO3− cotransporter (NBC, electrogenic NBCe1/e2 and electroneutral NBCn1) myocytes possess Cl-/HCO3− exchangers (SLC4 family members AE1, AE2, and AE3) and Cl-/OH- exchanger (CHE, with no molecular identity) alkali extruders3. SLC26 gene family members were identified as (mouse slc26a64 and its human orthologue SLC26A65, and slc26a36) responsible for Cl-/HCO3− and Cl-/OH- at plasma membrane of heart ventricles6. The work of Sirish et al7 in this issue revealed that ablation of slc26a6, a plasma membrane Cl-/HCO3- exchange protein, results in cardiac action potential (AP) shortening, cardiomyocyte Ca2+ transient (CaT) and sarcoplasmic reticulum (SR) Ca2+ load reduction, cardiomyocyte diminution of sarcomeric shortening, and cardiomyocyte intracellular pH (pHi) elevation. Moreover, in slc26a6-/- mice these factors led to a reduction of cardiac fractional shortening and cardiac contractility responses, and alterations of cardiac conduction system, as seen in sinus bradycardia and fragmentation of the QRS electrocardiographic-recorded complex. Since slc26a6 has stoichiometry of 2 (or more) HCO3-: Cl-, its transport function is electrogenic, with significance to the cardiomyocyte membrane potential. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/49489 Aiello, Ernesto Alejandro; Casey, Joseph R.; Alvarez, Bernardo; Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential; Lippincott Williams; Circulation-arrhythmia And Electrophysiology; 10; 10; 10-2017; 1-3 1941-3149 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/49489 |
identifier_str_mv |
Aiello, Ernesto Alejandro; Casey, Joseph R.; Alvarez, Bernardo; Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential; Lippincott Williams; Circulation-arrhythmia And Electrophysiology; 10; 10; 10-2017; 1-3 1941-3149 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://circep.ahajournals.org/content/10/10/e005812.long info:eu-repo/semantics/altIdentifier/doi/10.1161/CIRCEP.117.005812 info:eu-repo/semantics/altIdentifier/pmid/29025770 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Lippincott Williams |
publisher.none.fl_str_mv |
Lippincott Williams |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613299562348544 |
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13.070432 |