Sec22b is a critical and nonredundant regulator of plasma cell maintenance

Autores
Bonaud, Amélie; Gargowitsch, Laetitia; Gilbert, Simon M.; Rajan, Elanchezhian; Canales Herrerias, Pablo; Stockholm, Daniel; Rahman, Nabila F.; Collins, Mark O.; Taskiran, Hakan; Hill, Danika L.; Alloatti, Andrés; Alouche, Nagham; Balor, Stéphanie; Soldan, Vanessa; Gillet, Daniel; Barbier, Julien; Bachelerie, Françoise; Smith, Kenneth G. C.; Jellusova, Julia; Bruhns, Pierre; Amigorena, Sebastian; Balabanian, Karl; Linterman, Michelle A.; Peden, Andrew A.; Espéli, Marion
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced. Accordingly, Sec22b-deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and nonredundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.
Fil: Bonaud, Amélie. Centre National de la Recherche Scientifique; Francia
Fil: Gargowitsch, Laetitia. Universite Paris-Saclay ;
Fil: Gilbert, Simon M.. University of Cambridge; Estados Unidos
Fil: Rajan, Elanchezhian. University Of Sheffield (university Of Sheffield);
Fil: Canales Herrerias, Pablo. Universite de Paris; Francia
Fil: Stockholm, Daniel. Université Pierre et Marie Curie; Francia
Fil: Rahman, Nabila F.. Cardiff University; Reino Unido
Fil: Collins, Mark O.. University Of Sheffield (university Of Sheffield);
Fil: Taskiran, Hakan. Universitat Technical Zu Munich; Alemania
Fil: Hill, Danika L.. Monash University; Australia
Fil: Alloatti, Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Alouche, Nagham. Universite Paris-Saclay ;
Fil: Balor, Stéphanie. Centre National de la Recherche Scientifique; Francia
Fil: Soldan, Vanessa. Centre National de la Recherche Scientifique; Francia
Fil: Gillet, Daniel. Universite Paris-Saclay ;
Fil: Barbier, Julien. Universite Paris-Saclay ;
Fil: Bachelerie, Françoise. Universite Paris-Saclay ;
Fil: Smith, Kenneth G. C.. University of Cambridge; Estados Unidos
Fil: Jellusova, Julia. Universitat Technical Zu Munich; Alemania
Fil: Bruhns, Pierre. Universite de Paris; Francia
Fil: Amigorena, Sebastian. Inserm; Francia
Fil: Balabanian, Karl. Centre National de la Recherche Scientifique; Francia
Fil: Linterman, Michelle A.. Babraham Institute; Reino Unido
Fil: Peden, Andrew A.. University Of Sheffield (university Of Sheffield);
Fil: Espéli, Marion. Centre National de la Recherche Scientifique; Francia
Materia
ANTIBODY
ENDOPLASMIC RETICULUM
MITOCHONDRIA
PLASMA CELL
SNARE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240947
Acceder
id CONICETDig_490cc34ba08164604930ffd5b9ea4794
oai_identifier_str oai:ri.conicet.gov.ar:11336/240947
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sec22b is a critical and nonredundant regulator of plasma cell maintenanceBonaud, AmélieGargowitsch, LaetitiaGilbert, Simon M.Rajan, ElanchezhianCanales Herrerias, PabloStockholm, DanielRahman, Nabila F.Collins, Mark O.Taskiran, HakanHill, Danika L.Alloatti, AndrésAlouche, NaghamBalor, StéphanieSoldan, VanessaGillet, DanielBarbier, JulienBachelerie, FrançoiseSmith, Kenneth G. C.Jellusova, JuliaBruhns, PierreAmigorena, SebastianBalabanian, KarlLinterman, Michelle A.Peden, Andrew A.Espéli, MarionANTIBODYENDOPLASMIC RETICULUMMITOCHONDRIAPLASMA CELLSNAREhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced. Accordingly, Sec22b-deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and nonredundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.Fil: Bonaud, Amélie. Centre National de la Recherche Scientifique; FranciaFil: Gargowitsch, Laetitia. Universite Paris-Saclay ;Fil: Gilbert, Simon M.. University of Cambridge; Estados UnidosFil: Rajan, Elanchezhian. University Of Sheffield (university Of Sheffield);Fil: Canales Herrerias, Pablo. Universite de Paris; FranciaFil: Stockholm, Daniel. Université Pierre et Marie Curie; FranciaFil: Rahman, Nabila F.. Cardiff University; Reino UnidoFil: Collins, Mark O.. University Of Sheffield (university Of Sheffield);Fil: Taskiran, Hakan. Universitat Technical Zu Munich; AlemaniaFil: Hill, Danika L.. Monash University; AustraliaFil: Alloatti, Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Alouche, Nagham. Universite Paris-Saclay ;Fil: Balor, Stéphanie. Centre National de la Recherche Scientifique; FranciaFil: Soldan, Vanessa. Centre National de la Recherche Scientifique; FranciaFil: Gillet, Daniel. Universite Paris-Saclay ;Fil: Barbier, Julien. Universite Paris-Saclay ;Fil: Bachelerie, Françoise. Universite Paris-Saclay ;Fil: Smith, Kenneth G. C.. University of Cambridge; Estados UnidosFil: Jellusova, Julia. Universitat Technical Zu Munich; AlemaniaFil: Bruhns, Pierre. Universite de Paris; FranciaFil: Amigorena, Sebastian. Inserm; FranciaFil: Balabanian, Karl. Centre National de la Recherche Scientifique; FranciaFil: Linterman, Michelle A.. Babraham Institute; Reino UnidoFil: Peden, Andrew A.. University Of Sheffield (university Of Sheffield);Fil: Espéli, Marion. Centre National de la Recherche Scientifique; FranciaNational Academy of Sciences2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240947Bonaud, Amélie; Gargowitsch, Laetitia; Gilbert, Simon M.; Rajan, Elanchezhian; Canales Herrerias, Pablo; et al.; Sec22b is a critical and nonredundant regulator of plasma cell maintenance; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 120; 2; 1-2023; 1-120027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2213056120info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:16:07Zoai:ri.conicet.gov.ar:11336/240947instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:16:08.279CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sec22b is a critical and nonredundant regulator of plasma cell maintenance
title Sec22b is a critical and nonredundant regulator of plasma cell maintenance
spellingShingle Sec22b is a critical and nonredundant regulator of plasma cell maintenance
Bonaud, Amélie
ANTIBODY
ENDOPLASMIC RETICULUM
MITOCHONDRIA
PLASMA CELL
SNARE
title_short Sec22b is a critical and nonredundant regulator of plasma cell maintenance
title_full Sec22b is a critical and nonredundant regulator of plasma cell maintenance
title_fullStr Sec22b is a critical and nonredundant regulator of plasma cell maintenance
title_full_unstemmed Sec22b is a critical and nonredundant regulator of plasma cell maintenance
title_sort Sec22b is a critical and nonredundant regulator of plasma cell maintenance
dc.creator.none.fl_str_mv Bonaud, Amélie
Gargowitsch, Laetitia
Gilbert, Simon M.
Rajan, Elanchezhian
Canales Herrerias, Pablo
Stockholm, Daniel
Rahman, Nabila F.
Collins, Mark O.
Taskiran, Hakan
Hill, Danika L.
Alloatti, Andrés
Alouche, Nagham
Balor, Stéphanie
Soldan, Vanessa
Gillet, Daniel
Barbier, Julien
Bachelerie, Françoise
Smith, Kenneth G. C.
Jellusova, Julia
Bruhns, Pierre
Amigorena, Sebastian
Balabanian, Karl
Linterman, Michelle A.
Peden, Andrew A.
Espéli, Marion
author Bonaud, Amélie
author_facet Bonaud, Amélie
Gargowitsch, Laetitia
Gilbert, Simon M.
Rajan, Elanchezhian
Canales Herrerias, Pablo
Stockholm, Daniel
Rahman, Nabila F.
Collins, Mark O.
Taskiran, Hakan
Hill, Danika L.
Alloatti, Andrés
Alouche, Nagham
Balor, Stéphanie
Soldan, Vanessa
Gillet, Daniel
Barbier, Julien
Bachelerie, Françoise
Smith, Kenneth G. C.
Jellusova, Julia
Bruhns, Pierre
Amigorena, Sebastian
Balabanian, Karl
Linterman, Michelle A.
Peden, Andrew A.
Espéli, Marion
author_role author
author2 Gargowitsch, Laetitia
Gilbert, Simon M.
Rajan, Elanchezhian
Canales Herrerias, Pablo
Stockholm, Daniel
Rahman, Nabila F.
Collins, Mark O.
Taskiran, Hakan
Hill, Danika L.
Alloatti, Andrés
Alouche, Nagham
Balor, Stéphanie
Soldan, Vanessa
Gillet, Daniel
Barbier, Julien
Bachelerie, Françoise
Smith, Kenneth G. C.
Jellusova, Julia
Bruhns, Pierre
Amigorena, Sebastian
Balabanian, Karl
Linterman, Michelle A.
Peden, Andrew A.
Espéli, Marion
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBODY
ENDOPLASMIC RETICULUM
MITOCHONDRIA
PLASMA CELL
SNARE
topic ANTIBODY
ENDOPLASMIC RETICULUM
MITOCHONDRIA
PLASMA CELL
SNARE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced. Accordingly, Sec22b-deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and nonredundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.
Fil: Bonaud, Amélie. Centre National de la Recherche Scientifique; Francia
Fil: Gargowitsch, Laetitia. Universite Paris-Saclay ;
Fil: Gilbert, Simon M.. University of Cambridge; Estados Unidos
Fil: Rajan, Elanchezhian. University Of Sheffield (university Of Sheffield);
Fil: Canales Herrerias, Pablo. Universite de Paris; Francia
Fil: Stockholm, Daniel. Université Pierre et Marie Curie; Francia
Fil: Rahman, Nabila F.. Cardiff University; Reino Unido
Fil: Collins, Mark O.. University Of Sheffield (university Of Sheffield);
Fil: Taskiran, Hakan. Universitat Technical Zu Munich; Alemania
Fil: Hill, Danika L.. Monash University; Australia
Fil: Alloatti, Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Alouche, Nagham. Universite Paris-Saclay ;
Fil: Balor, Stéphanie. Centre National de la Recherche Scientifique; Francia
Fil: Soldan, Vanessa. Centre National de la Recherche Scientifique; Francia
Fil: Gillet, Daniel. Universite Paris-Saclay ;
Fil: Barbier, Julien. Universite Paris-Saclay ;
Fil: Bachelerie, Françoise. Universite Paris-Saclay ;
Fil: Smith, Kenneth G. C.. University of Cambridge; Estados Unidos
Fil: Jellusova, Julia. Universitat Technical Zu Munich; Alemania
Fil: Bruhns, Pierre. Universite de Paris; Francia
Fil: Amigorena, Sebastian. Inserm; Francia
Fil: Balabanian, Karl. Centre National de la Recherche Scientifique; Francia
Fil: Linterman, Michelle A.. Babraham Institute; Reino Unido
Fil: Peden, Andrew A.. University Of Sheffield (university Of Sheffield);
Fil: Espéli, Marion. Centre National de la Recherche Scientifique; Francia
description Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced. Accordingly, Sec22b-deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and nonredundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240947
Bonaud, Amélie; Gargowitsch, Laetitia; Gilbert, Simon M.; Rajan, Elanchezhian; Canales Herrerias, Pablo; et al.; Sec22b is a critical and nonredundant regulator of plasma cell maintenance; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 120; 2; 1-2023; 1-12
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240947
identifier_str_mv Bonaud, Amélie; Gargowitsch, Laetitia; Gilbert, Simon M.; Rajan, Elanchezhian; Canales Herrerias, Pablo; et al.; Sec22b is a critical and nonredundant regulator of plasma cell maintenance; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 120; 2; 1-2023; 1-12
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2213056120
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781605684707328
score 12.982451

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