Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute e...

Autores
Raggio, María Celeste; Coronel, Maria Florencia; Ferreyra, Sol; Labombarda, Maria Florencia; Gonzalez, Susana Laura
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Neuroinflammation is a hallmark of central nervous system pathologies, including spinal cord injury (SCI). In particular, the acute activation of macrophages and resident microglia are critically implicated in the detrimental long-standing consequences of spinal trauma, such as the onset and maintenance of neuropathic pain [5]. Indeed, the fine-tuning of microglia/macrophage polarization from classically-activated (M1, inflammatory) towards alternatively-activated (M2, anti-inflammatory) states represents an active research focus of restorative strategies in a wide range of experimental nervous system trauma, including SCI [1], and may offer a therapeutic opportunity to prevent the risk of developing pain later. We have previously shown that progesterone, a neuroactive steroid, exhibits neuroprotective and pro-myelinating actions in experimental spinal lesions [3, 6] and could stand as a promising repositioning molecule for timely targeting the harmful aspects of acute inflammation [2, 4], while preserving anti-inflammatory and pro-reparative features.
Fil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universite de Strasbourg. Unite de Recherche.; Francia. Inserm; Francia
Fil: Coronel, Maria Florencia. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Ferreyra, Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina
Virtual International Meeting Steroids and Nervous System
Torino
Italia
Università degli Studi di Milano Statale
Università degli Studi di Torino
Materia
PROGESTERONE
MICROGLIA
SPINAL CORD INJURY
NEUROPHATIC PAIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150762
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/150762
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injuryRaggio, María CelesteCoronel, Maria FlorenciaFerreyra, SolLabombarda, Maria FlorenciaGonzalez, Susana LauraPROGESTERONEMICROGLIASPINAL CORD INJURYNEUROPHATIC PAINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neuroinflammation is a hallmark of central nervous system pathologies, including spinal cord injury (SCI). In particular, the acute activation of macrophages and resident microglia are critically implicated in the detrimental long-standing consequences of spinal trauma, such as the onset and maintenance of neuropathic pain [5]. Indeed, the fine-tuning of microglia/macrophage polarization from classically-activated (M1, inflammatory) towards alternatively-activated (M2, anti-inflammatory) states represents an active research focus of restorative strategies in a wide range of experimental nervous system trauma, including SCI [1], and may offer a therapeutic opportunity to prevent the risk of developing pain later. We have previously shown that progesterone, a neuroactive steroid, exhibits neuroprotective and pro-myelinating actions in experimental spinal lesions [3, 6] and could stand as a promising repositioning molecule for timely targeting the harmful aspects of acute inflammation [2, 4], while preserving anti-inflammatory and pro-reparative features.Fil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universite de Strasbourg. Unite de Recherche.; Francia. Inserm; FranciaFil: Coronel, Maria Florencia. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Ferreyra, Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; ArgentinaVirtual International Meeting Steroids and Nervous SystemTorinoItaliaUniversità degli Studi di Milano StataleUniversità degli Studi di TorinoFondazione Cavalieri OttolenghiPanzica, G. C.Gotti, S.2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150762Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury; Virtual International Meeting Steroids and Nervous System; Torino; Italia; 2021; 111-112CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://sites.google.com/view/neurosteroids2021/programInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:09Zoai:ri.conicet.gov.ar:11336/150762instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:10.005CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
title Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
spellingShingle Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
Raggio, María Celeste
PROGESTERONE
MICROGLIA
SPINAL CORD INJURY
NEUROPHATIC PAIN
title_short Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
title_full Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
title_fullStr Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
title_full_unstemmed Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
title_sort Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
dc.creator.none.fl_str_mv Raggio, María Celeste
Coronel, Maria Florencia
Ferreyra, Sol
Labombarda, Maria Florencia
Gonzalez, Susana Laura
author Raggio, María Celeste
author_facet Raggio, María Celeste
Coronel, Maria Florencia
Ferreyra, Sol
Labombarda, Maria Florencia
Gonzalez, Susana Laura
author_role author
author2 Coronel, Maria Florencia
Ferreyra, Sol
Labombarda, Maria Florencia
Gonzalez, Susana Laura
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Panzica, G. C.
Gotti, S.
dc.subject.none.fl_str_mv PROGESTERONE
MICROGLIA
SPINAL CORD INJURY
NEUROPHATIC PAIN
topic PROGESTERONE
MICROGLIA
SPINAL CORD INJURY
NEUROPHATIC PAIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neuroinflammation is a hallmark of central nervous system pathologies, including spinal cord injury (SCI). In particular, the acute activation of macrophages and resident microglia are critically implicated in the detrimental long-standing consequences of spinal trauma, such as the onset and maintenance of neuropathic pain [5]. Indeed, the fine-tuning of microglia/macrophage polarization from classically-activated (M1, inflammatory) towards alternatively-activated (M2, anti-inflammatory) states represents an active research focus of restorative strategies in a wide range of experimental nervous system trauma, including SCI [1], and may offer a therapeutic opportunity to prevent the risk of developing pain later. We have previously shown that progesterone, a neuroactive steroid, exhibits neuroprotective and pro-myelinating actions in experimental spinal lesions [3, 6] and could stand as a promising repositioning molecule for timely targeting the harmful aspects of acute inflammation [2, 4], while preserving anti-inflammatory and pro-reparative features.
Fil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universite de Strasbourg. Unite de Recherche.; Francia. Inserm; Francia
Fil: Coronel, Maria Florencia. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Ferreyra, Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina
Virtual International Meeting Steroids and Nervous System
Torino
Italia
Università degli Studi di Milano Statale
Università degli Studi di Torino
description Neuroinflammation is a hallmark of central nervous system pathologies, including spinal cord injury (SCI). In particular, the acute activation of macrophages and resident microglia are critically implicated in the detrimental long-standing consequences of spinal trauma, such as the onset and maintenance of neuropathic pain [5]. Indeed, the fine-tuning of microglia/macrophage polarization from classically-activated (M1, inflammatory) towards alternatively-activated (M2, anti-inflammatory) states represents an active research focus of restorative strategies in a wide range of experimental nervous system trauma, including SCI [1], and may offer a therapeutic opportunity to prevent the risk of developing pain later. We have previously shown that progesterone, a neuroactive steroid, exhibits neuroprotective and pro-myelinating actions in experimental spinal lesions [3, 6] and could stand as a promising repositioning molecule for timely targeting the harmful aspects of acute inflammation [2, 4], while preserving anti-inflammatory and pro-reparative features.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150762
Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury; Virtual International Meeting Steroids and Nervous System; Torino; Italia; 2021; 111-112
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150762
identifier_str_mv Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury; Virtual International Meeting Steroids and Nervous System; Torino; Italia; 2021; 111-112
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://sites.google.com/view/neurosteroids2021/program
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Fondazione Cavalieri Ottolenghi
publisher.none.fl_str_mv Fondazione Cavalieri Ottolenghi
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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