Extracellular vesicles and chronic inflammation during HIV infection

Autores
Pérez, Paula Soledad; Romaniuk, Maria Albertina; Duette, Gabriel; Zhao, Zezhou; Huang, Yiyao; Martin-Jaular, Lorena; Witwer, Kenneth W.; Théry, Clotilde; Ostrowski, Matias
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Inflammation is a hallmark of HIV infection. Among the multiple stimuli that can induce inflammation in untreated infection, ongoing viral replication is a primary driver. After initiation of effective combined antiretroviral therapy (cART), HIV replication is drastically reduced or halted. However, even virologically controlled patients may continue to have abnormal levels of inflammation. A number of factors have been proposed to cause inflammation in HIV infection: among others, residual (low-level) HIV replication, production of HIV protein or RNA in the absence of replication, microbial translocation from the gut to the circulation, co-infections, and loss of immunoregulatory responses. Importantly, chronic inflammation in HIV-infected individuals increases the risk for a number of non-infectious co-morbidities, including cancer and cardiovascular disease. Thus, achieving a better understanding of the underlying mechanisms of HIV-associated inflammation in the presence of cART is of utmost importance. Extracellular vesicles have emerged as novel actors in intercellular communication, involved in a myriad of physiological and pathological processes, including inflammation. In this review, we will discuss the role of extracellular vesicles in the pathogenesis of HIV infection, with particular emphasis on their role as inducers of chronic inflammation.
Fil: Pérez, Paula Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Romaniuk, Maria Albertina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Zhao, Zezhou. The Johns Hopkins University School Of Medicine; Estados Unidos
Fil: Huang, Yiyao. The Johns Hopkins University School Of Medicine; Estados Unidos
Fil: Martin-Jaular, Lorena. PSL Research University; Francia. Inserm; Francia
Fil: Witwer, Kenneth W.. The Johns Hopkins University School Of Medicine; Estados Unidos
Fil: Théry, Clotilde. PSL Research University; Francia. Inserm; Francia
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
EXOSOMES
EXTRACELLULAR VESICLES
HIF-1Α
HIV
INFLAMMATION
PRO-INFLAMMATORY CYTOKINES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125053
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125053
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Extracellular vesicles and chronic inflammation during HIV infectionPérez, Paula SoledadRomaniuk, Maria AlbertinaDuette, GabrielZhao, ZezhouHuang, YiyaoMartin-Jaular, LorenaWitwer, Kenneth W.Théry, ClotildeOstrowski, MatiasEXOSOMESEXTRACELLULAR VESICLESHIF-1ΑHIVINFLAMMATIONPRO-INFLAMMATORY CYTOKINEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Inflammation is a hallmark of HIV infection. Among the multiple stimuli that can induce inflammation in untreated infection, ongoing viral replication is a primary driver. After initiation of effective combined antiretroviral therapy (cART), HIV replication is drastically reduced or halted. However, even virologically controlled patients may continue to have abnormal levels of inflammation. A number of factors have been proposed to cause inflammation in HIV infection: among others, residual (low-level) HIV replication, production of HIV protein or RNA in the absence of replication, microbial translocation from the gut to the circulation, co-infections, and loss of immunoregulatory responses. Importantly, chronic inflammation in HIV-infected individuals increases the risk for a number of non-infectious co-morbidities, including cancer and cardiovascular disease. Thus, achieving a better understanding of the underlying mechanisms of HIV-associated inflammation in the presence of cART is of utmost importance. Extracellular vesicles have emerged as novel actors in intercellular communication, involved in a myriad of physiological and pathological processes, including inflammation. In this review, we will discuss the role of extracellular vesicles in the pathogenesis of HIV infection, with particular emphasis on their role as inducers of chronic inflammation.Fil: Pérez, Paula Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Romaniuk, Maria Albertina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Zhao, Zezhou. The Johns Hopkins University School Of Medicine; Estados UnidosFil: Huang, Yiyao. The Johns Hopkins University School Of Medicine; Estados UnidosFil: Martin-Jaular, Lorena. PSL Research University; Francia. Inserm; FranciaFil: Witwer, Kenneth W.. The Johns Hopkins University School Of Medicine; Estados UnidosFil: Théry, Clotilde. PSL Research University; Francia. Inserm; FranciaFil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaTaylor & Francis2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125053Pérez, Paula Soledad; Romaniuk, Maria Albertina; Duette, Gabriel; Zhao, Zezhou; Huang, Yiyao; et al.; Extracellular vesicles and chronic inflammation during HIV infection; Taylor & Francis; Journal of Extracellular Vesicles; 8; 1; 12-2019; 1-172001-3078CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/20013078.2019.1687275info:eu-repo/semantics/altIdentifier/doi/10.1080/20013078.2019.1687275info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:32Zoai:ri.conicet.gov.ar:11336/125053instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:32.973CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Extracellular vesicles and chronic inflammation during HIV infection
title Extracellular vesicles and chronic inflammation during HIV infection
spellingShingle Extracellular vesicles and chronic inflammation during HIV infection
Pérez, Paula Soledad
EXOSOMES
EXTRACELLULAR VESICLES
HIF-1Α
HIV
INFLAMMATION
PRO-INFLAMMATORY CYTOKINES
title_short Extracellular vesicles and chronic inflammation during HIV infection
title_full Extracellular vesicles and chronic inflammation during HIV infection
title_fullStr Extracellular vesicles and chronic inflammation during HIV infection
title_full_unstemmed Extracellular vesicles and chronic inflammation during HIV infection
title_sort Extracellular vesicles and chronic inflammation during HIV infection
dc.creator.none.fl_str_mv Pérez, Paula Soledad
Romaniuk, Maria Albertina
Duette, Gabriel
Zhao, Zezhou
Huang, Yiyao
Martin-Jaular, Lorena
Witwer, Kenneth W.
Théry, Clotilde
Ostrowski, Matias
author Pérez, Paula Soledad
author_facet Pérez, Paula Soledad
Romaniuk, Maria Albertina
Duette, Gabriel
Zhao, Zezhou
Huang, Yiyao
Martin-Jaular, Lorena
Witwer, Kenneth W.
Théry, Clotilde
Ostrowski, Matias
author_role author
author2 Romaniuk, Maria Albertina
Duette, Gabriel
Zhao, Zezhou
Huang, Yiyao
Martin-Jaular, Lorena
Witwer, Kenneth W.
Théry, Clotilde
Ostrowski, Matias
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EXOSOMES
EXTRACELLULAR VESICLES
HIF-1Α
HIV
INFLAMMATION
PRO-INFLAMMATORY CYTOKINES
topic EXOSOMES
EXTRACELLULAR VESICLES
HIF-1Α
HIV
INFLAMMATION
PRO-INFLAMMATORY CYTOKINES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Inflammation is a hallmark of HIV infection. Among the multiple stimuli that can induce inflammation in untreated infection, ongoing viral replication is a primary driver. After initiation of effective combined antiretroviral therapy (cART), HIV replication is drastically reduced or halted. However, even virologically controlled patients may continue to have abnormal levels of inflammation. A number of factors have been proposed to cause inflammation in HIV infection: among others, residual (low-level) HIV replication, production of HIV protein or RNA in the absence of replication, microbial translocation from the gut to the circulation, co-infections, and loss of immunoregulatory responses. Importantly, chronic inflammation in HIV-infected individuals increases the risk for a number of non-infectious co-morbidities, including cancer and cardiovascular disease. Thus, achieving a better understanding of the underlying mechanisms of HIV-associated inflammation in the presence of cART is of utmost importance. Extracellular vesicles have emerged as novel actors in intercellular communication, involved in a myriad of physiological and pathological processes, including inflammation. In this review, we will discuss the role of extracellular vesicles in the pathogenesis of HIV infection, with particular emphasis on their role as inducers of chronic inflammation.
Fil: Pérez, Paula Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Romaniuk, Maria Albertina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Zhao, Zezhou. The Johns Hopkins University School Of Medicine; Estados Unidos
Fil: Huang, Yiyao. The Johns Hopkins University School Of Medicine; Estados Unidos
Fil: Martin-Jaular, Lorena. PSL Research University; Francia. Inserm; Francia
Fil: Witwer, Kenneth W.. The Johns Hopkins University School Of Medicine; Estados Unidos
Fil: Théry, Clotilde. PSL Research University; Francia. Inserm; Francia
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Inflammation is a hallmark of HIV infection. Among the multiple stimuli that can induce inflammation in untreated infection, ongoing viral replication is a primary driver. After initiation of effective combined antiretroviral therapy (cART), HIV replication is drastically reduced or halted. However, even virologically controlled patients may continue to have abnormal levels of inflammation. A number of factors have been proposed to cause inflammation in HIV infection: among others, residual (low-level) HIV replication, production of HIV protein or RNA in the absence of replication, microbial translocation from the gut to the circulation, co-infections, and loss of immunoregulatory responses. Importantly, chronic inflammation in HIV-infected individuals increases the risk for a number of non-infectious co-morbidities, including cancer and cardiovascular disease. Thus, achieving a better understanding of the underlying mechanisms of HIV-associated inflammation in the presence of cART is of utmost importance. Extracellular vesicles have emerged as novel actors in intercellular communication, involved in a myriad of physiological and pathological processes, including inflammation. In this review, we will discuss the role of extracellular vesicles in the pathogenesis of HIV infection, with particular emphasis on their role as inducers of chronic inflammation.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125053
Pérez, Paula Soledad; Romaniuk, Maria Albertina; Duette, Gabriel; Zhao, Zezhou; Huang, Yiyao; et al.; Extracellular vesicles and chronic inflammation during HIV infection; Taylor & Francis; Journal of Extracellular Vesicles; 8; 1; 12-2019; 1-17
2001-3078
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125053
identifier_str_mv Pérez, Paula Soledad; Romaniuk, Maria Albertina; Duette, Gabriel; Zhao, Zezhou; Huang, Yiyao; et al.; Extracellular vesicles and chronic inflammation during HIV infection; Taylor & Francis; Journal of Extracellular Vesicles; 8; 1; 12-2019; 1-17
2001-3078
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/20013078.2019.1687275
info:eu-repo/semantics/altIdentifier/doi/10.1080/20013078.2019.1687275
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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