Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2

Autores
Martín Giménez, Virna Margarita; Inserra, Felipe; Ferder, Leon Fernando; García, Joxel; Manucha, Walter Ariel Fernando
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
COVID-19 is said to be a pandemic that does not distinguish skin color or ethnic origin, but data in many parts of the world, especially in the United States, begins to show that there is a sector of society that is suffering a more significant impact from this pandemic. The black population is being more vulnerable than the white population to infection and death by COVID-19, and hypertension and diabetes mellitus seems to predispose to this vulnerability. Over time, multiple disparities have been observed between the health of blacks and whites, mainly associated with inequalities in the socio-economic scope. However, little by little, some mechanisms and pathophysiological susceptibilities that are directly related to the higher prevalence of multiple diseases in the black population, including infection and death by COVID-19, begin to be elucidated.Plasma vitamin D levels and evolutionary adaptations of the renin-angiotensin-aldosterone system in black people are considerably different between this and other races, and it is well established their role in the development and progression of hypertension and multiple lung diseases, among them, COVID-19 infection.This letter to discuss and proposes whether or not vitamin D and renin-angiotensin-aldosterone system ethnical disparities influence susceptibility to infection and death by COVID-19 in black people and suggests possible mechanisms for this susceptibility.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Inserra, Felipe. Universidad Maimónides; Argentina
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
Fil: García, Joxel. Ambitious Solutions for Health Cures; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
COVID-19
VITAMIN D
INFLAMMATION
TREATMENT
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112133
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2Martín Giménez, Virna MargaritaInserra, FelipeFerder, Leon FernandoGarcía, JoxelManucha, Walter Ariel FernandoCOVID-19VITAMIN DINFLAMMATIONTREATMENTCOVID-19https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3COVID-19 is said to be a pandemic that does not distinguish skin color or ethnic origin, but data in many parts of the world, especially in the United States, begins to show that there is a sector of society that is suffering a more significant impact from this pandemic. The black population is being more vulnerable than the white population to infection and death by COVID-19, and hypertension and diabetes mellitus seems to predispose to this vulnerability. Over time, multiple disparities have been observed between the health of blacks and whites, mainly associated with inequalities in the socio-economic scope. However, little by little, some mechanisms and pathophysiological susceptibilities that are directly related to the higher prevalence of multiple diseases in the black population, including infection and death by COVID-19, begin to be elucidated.Plasma vitamin D levels and evolutionary adaptations of the renin-angiotensin-aldosterone system in black people are considerably different between this and other races, and it is well established their role in the development and progression of hypertension and multiple lung diseases, among them, COVID-19 infection.This letter to discuss and proposes whether or not vitamin D and renin-angiotensin-aldosterone system ethnical disparities influence susceptibility to infection and death by COVID-19 in black people and suggests possible mechanisms for this susceptibility.Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Inserra, Felipe. Universidad Maimónides; ArgentinaFil: Ferder, Leon Fernando. Universidad Maimónides; ArgentinaFil: García, Joxel. Ambitious Solutions for Health Cures; Estados UnidosFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaNature Publishing Group2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112133Martín Giménez, Virna Margarita; Inserra, Felipe; Ferder, Leon Fernando; García, Joxel; Manucha, Walter Ariel Fernando; Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2; Nature Publishing Group; Journal Of Human Hypertension; 9-2020; 1-30950-9240CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41371-020-00398-zinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41371-020-00398-zinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425793/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:30Zoai:ri.conicet.gov.ar:11336/112133instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:30.492CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
title Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
spellingShingle Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
Martín Giménez, Virna Margarita
COVID-19
VITAMIN D
INFLAMMATION
TREATMENT
COVID-19
title_short Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
title_full Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
title_fullStr Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
title_full_unstemmed Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
title_sort Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
Inserra, Felipe
Ferder, Leon Fernando
García, Joxel
Manucha, Walter Ariel Fernando
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
Inserra, Felipe
Ferder, Leon Fernando
García, Joxel
Manucha, Walter Ariel Fernando
author_role author
author2 Inserra, Felipe
Ferder, Leon Fernando
García, Joxel
Manucha, Walter Ariel Fernando
author2_role author
author
author
author
dc.subject.none.fl_str_mv COVID-19
VITAMIN D
INFLAMMATION
TREATMENT
COVID-19
topic COVID-19
VITAMIN D
INFLAMMATION
TREATMENT
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv COVID-19 is said to be a pandemic that does not distinguish skin color or ethnic origin, but data in many parts of the world, especially in the United States, begins to show that there is a sector of society that is suffering a more significant impact from this pandemic. The black population is being more vulnerable than the white population to infection and death by COVID-19, and hypertension and diabetes mellitus seems to predispose to this vulnerability. Over time, multiple disparities have been observed between the health of blacks and whites, mainly associated with inequalities in the socio-economic scope. However, little by little, some mechanisms and pathophysiological susceptibilities that are directly related to the higher prevalence of multiple diseases in the black population, including infection and death by COVID-19, begin to be elucidated.Plasma vitamin D levels and evolutionary adaptations of the renin-angiotensin-aldosterone system in black people are considerably different between this and other races, and it is well established their role in the development and progression of hypertension and multiple lung diseases, among them, COVID-19 infection.This letter to discuss and proposes whether or not vitamin D and renin-angiotensin-aldosterone system ethnical disparities influence susceptibility to infection and death by COVID-19 in black people and suggests possible mechanisms for this susceptibility.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Inserra, Felipe. Universidad Maimónides; Argentina
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
Fil: García, Joxel. Ambitious Solutions for Health Cures; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description COVID-19 is said to be a pandemic that does not distinguish skin color or ethnic origin, but data in many parts of the world, especially in the United States, begins to show that there is a sector of society that is suffering a more significant impact from this pandemic. The black population is being more vulnerable than the white population to infection and death by COVID-19, and hypertension and diabetes mellitus seems to predispose to this vulnerability. Over time, multiple disparities have been observed between the health of blacks and whites, mainly associated with inequalities in the socio-economic scope. However, little by little, some mechanisms and pathophysiological susceptibilities that are directly related to the higher prevalence of multiple diseases in the black population, including infection and death by COVID-19, begin to be elucidated.Plasma vitamin D levels and evolutionary adaptations of the renin-angiotensin-aldosterone system in black people are considerably different between this and other races, and it is well established their role in the development and progression of hypertension and multiple lung diseases, among them, COVID-19 infection.This letter to discuss and proposes whether or not vitamin D and renin-angiotensin-aldosterone system ethnical disparities influence susceptibility to infection and death by COVID-19 in black people and suggests possible mechanisms for this susceptibility.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112133
Martín Giménez, Virna Margarita; Inserra, Felipe; Ferder, Leon Fernando; García, Joxel; Manucha, Walter Ariel Fernando; Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2; Nature Publishing Group; Journal Of Human Hypertension; 9-2020; 1-3
0950-9240
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112133
identifier_str_mv Martín Giménez, Virna Margarita; Inserra, Felipe; Ferder, Leon Fernando; García, Joxel; Manucha, Walter Ariel Fernando; Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2; Nature Publishing Group; Journal Of Human Hypertension; 9-2020; 1-3
0950-9240
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41371-020-00398-z
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41371-020-00398-z
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425793/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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