Immune system modulation produced by ultraviolet radiation

Autores
Cela, Eliana Maiten; Paz, Mariela Laura; Leoni, Juliana; Gonzalez Maglio, Daniel Horacio
Año de publicación
2018
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Exposure to ultraviolet radiation (UVr) contained in sunlight is a major cause of skin illness, such as sunburn, aging and cancer. UVr triggers local effects on the skin, which involve local inflammation, tissue remodel, regulatory cytokines release and migration of dendritic cells (DCs). However, these localized effects on the exposed area are not the only ones that take place after sun or UVr exposure. A less known effect of UVr is the modulation of systemic immunity, through the generation of specific regulatory cells. These cells are induced, at least in part, by skin-migrating tolerogenic DCs. Moreover, bone marrow cell precursors can also be biased to a tolerogenic or suppressor phenotype.The sunlight or UVr-induced immune system modulation can cause skin disorders, like skin cancer and cutaneous photosensitivity in Lupus, but it also may be useful to treat cutaneous pathologies, such as psoriasis and vitiligo. Moreover, the systemic immunosuppressor effect of UVr-exposure may also be useful to treat autoimmunity of internal organs. Finally, as an inducer of cutaneous inflammatory response, UV phototherapy may also be useful in the treatment of cutaneous infections.Overall, UVr has profound immunomodulatory capacity that can be useful or deleterious for human health.
Fil: Cela, Eliana Maiten. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Paz, Mariela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Leoni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Materia
SKIN
SUNLIGHT
IMMUNOSUPPRESSION
CANCER
AUTOIMMUNTY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/132670
Acceder
id CONICETDig_132f0a2af31bbce1f4dfc0fdb7f2c18f
oai_identifier_str oai:ri.conicet.gov.ar:11336/132670
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immune system modulation produced by ultraviolet radiationCela, Eliana MaitenPaz, Mariela LauraLeoni, JulianaGonzalez Maglio, Daniel HoracioSKINSUNLIGHTIMMUNOSUPPRESSIONCANCERAUTOIMMUNTYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Exposure to ultraviolet radiation (UVr) contained in sunlight is a major cause of skin illness, such as sunburn, aging and cancer. UVr triggers local effects on the skin, which involve local inflammation, tissue remodel, regulatory cytokines release and migration of dendritic cells (DCs). However, these localized effects on the exposed area are not the only ones that take place after sun or UVr exposure. A less known effect of UVr is the modulation of systemic immunity, through the generation of specific regulatory cells. These cells are induced, at least in part, by skin-migrating tolerogenic DCs. Moreover, bone marrow cell precursors can also be biased to a tolerogenic or suppressor phenotype.The sunlight or UVr-induced immune system modulation can cause skin disorders, like skin cancer and cutaneous photosensitivity in Lupus, but it also may be useful to treat cutaneous pathologies, such as psoriasis and vitiligo. Moreover, the systemic immunosuppressor effect of UVr-exposure may also be useful to treat autoimmunity of internal organs. Finally, as an inducer of cutaneous inflammatory response, UV phototherapy may also be useful in the treatment of cutaneous infections.Overall, UVr has profound immunomodulatory capacity that can be useful or deleterious for human health.Fil: Cela, Eliana Maiten. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Paz, Mariela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Leoni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaIntechOpenShamsadin Athari, Seyyed2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/132670Cela, Eliana Maiten; Paz, Mariela Laura; Leoni, Juliana; Gonzalez Maglio, Daniel Horacio; Immune system modulation produced by ultraviolet radiation; IntechOpen; 5; 2018; 103-121978-1-83881-592-9CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/60355info:eu-repo/semantics/altIdentifier/doi/10.5772/intechopen.75450info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:03Zoai:ri.conicet.gov.ar:11336/132670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:04.256CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immune system modulation produced by ultraviolet radiation
title Immune system modulation produced by ultraviolet radiation
spellingShingle Immune system modulation produced by ultraviolet radiation
Cela, Eliana Maiten
SKIN
SUNLIGHT
IMMUNOSUPPRESSION
CANCER
AUTOIMMUNTY
title_short Immune system modulation produced by ultraviolet radiation
title_full Immune system modulation produced by ultraviolet radiation
title_fullStr Immune system modulation produced by ultraviolet radiation
title_full_unstemmed Immune system modulation produced by ultraviolet radiation
title_sort Immune system modulation produced by ultraviolet radiation
dc.creator.none.fl_str_mv Cela, Eliana Maiten
Paz, Mariela Laura
Leoni, Juliana
Gonzalez Maglio, Daniel Horacio
author Cela, Eliana Maiten
author_facet Cela, Eliana Maiten
Paz, Mariela Laura
Leoni, Juliana
Gonzalez Maglio, Daniel Horacio
author_role author
author2 Paz, Mariela Laura
Leoni, Juliana
Gonzalez Maglio, Daniel Horacio
author2_role author
author
author
dc.contributor.none.fl_str_mv Shamsadin Athari, Seyyed
dc.subject.none.fl_str_mv SKIN
SUNLIGHT
IMMUNOSUPPRESSION
CANCER
AUTOIMMUNTY
topic SKIN
SUNLIGHT
IMMUNOSUPPRESSION
CANCER
AUTOIMMUNTY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Exposure to ultraviolet radiation (UVr) contained in sunlight is a major cause of skin illness, such as sunburn, aging and cancer. UVr triggers local effects on the skin, which involve local inflammation, tissue remodel, regulatory cytokines release and migration of dendritic cells (DCs). However, these localized effects on the exposed area are not the only ones that take place after sun or UVr exposure. A less known effect of UVr is the modulation of systemic immunity, through the generation of specific regulatory cells. These cells are induced, at least in part, by skin-migrating tolerogenic DCs. Moreover, bone marrow cell precursors can also be biased to a tolerogenic or suppressor phenotype.The sunlight or UVr-induced immune system modulation can cause skin disorders, like skin cancer and cutaneous photosensitivity in Lupus, but it also may be useful to treat cutaneous pathologies, such as psoriasis and vitiligo. Moreover, the systemic immunosuppressor effect of UVr-exposure may also be useful to treat autoimmunity of internal organs. Finally, as an inducer of cutaneous inflammatory response, UV phototherapy may also be useful in the treatment of cutaneous infections.Overall, UVr has profound immunomodulatory capacity that can be useful or deleterious for human health.
Fil: Cela, Eliana Maiten. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Paz, Mariela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Leoni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
description Exposure to ultraviolet radiation (UVr) contained in sunlight is a major cause of skin illness, such as sunburn, aging and cancer. UVr triggers local effects on the skin, which involve local inflammation, tissue remodel, regulatory cytokines release and migration of dendritic cells (DCs). However, these localized effects on the exposed area are not the only ones that take place after sun or UVr exposure. A less known effect of UVr is the modulation of systemic immunity, through the generation of specific regulatory cells. These cells are induced, at least in part, by skin-migrating tolerogenic DCs. Moreover, bone marrow cell precursors can also be biased to a tolerogenic or suppressor phenotype.The sunlight or UVr-induced immune system modulation can cause skin disorders, like skin cancer and cutaneous photosensitivity in Lupus, but it also may be useful to treat cutaneous pathologies, such as psoriasis and vitiligo. Moreover, the systemic immunosuppressor effect of UVr-exposure may also be useful to treat autoimmunity of internal organs. Finally, as an inducer of cutaneous inflammatory response, UV phototherapy may also be useful in the treatment of cutaneous infections.Overall, UVr has profound immunomodulatory capacity that can be useful or deleterious for human health.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/132670
Cela, Eliana Maiten; Paz, Mariela Laura; Leoni, Juliana; Gonzalez Maglio, Daniel Horacio; Immune system modulation produced by ultraviolet radiation; IntechOpen; 5; 2018; 103-121
978-1-83881-592-9
CONICET Digital
CONICET
url http://hdl.handle.net/11336/132670
identifier_str_mv Cela, Eliana Maiten; Paz, Mariela Laura; Leoni, Juliana; Gonzalez Maglio, Daniel Horacio; Immune system modulation produced by ultraviolet radiation; IntechOpen; 5; 2018; 103-121
978-1-83881-592-9
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/60355
info:eu-repo/semantics/altIdentifier/doi/10.5772/intechopen.75450
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IntechOpen
publisher.none.fl_str_mv IntechOpen
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082658255241216
score 13.22299

Publicaciones similares