Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi

Autores
Canepa, Gaspar Exequiel; Bouvier, León Alberto; Urias, Ursula; Miranda, Mariana Reneé; Colli, W.; Alves, M.; Pereira, Claudio Alejandro
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aspartate is one of the compounds that induce the differentiation process of the non-infective epimastigote stage to the infective trypomastigote stage of the protozoan parasite Trypanosoma cruzi. l-aspartate is transported by both epimastigote and trypomastigote cells at the same rate, about 3.4 pmol min -1 per 107 cells. Aspartate transport is only competed by glutamate suggesting that this transport system is specific for anionic amino acids. Aspartate uptake rates increase along the parasite growth curve, by amino acids starvation or pH decrease. The metabolic fate of the transported aspartate was predicted in silico by identification of seven putative genes coding for enzymes involved in aspartate metabolism that could be related to the differentiation process.
Fil: Canepa, Gaspar Exequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Bouvier, León Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Urias, Ursula. Universidade de Sao Paulo; Brasil
Fil: Miranda, Mariana Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Colli, W.. Universidade de Sao Paulo; Brasil
Fil: Alves, M.. Universidade de Sao Paulo; Brasil
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
AMINO ACID TRANSPORTER
ASPARTATE
CHAGAS DISEASE
GLUTAMATE
METABOLITE TRANSPORT
TRYPANOSOMA CRUZI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129442
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/129442
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruziCanepa, Gaspar ExequielBouvier, León AlbertoUrias, UrsulaMiranda, Mariana ReneéColli, W.Alves, M.Pereira, Claudio AlejandroAMINO ACID TRANSPORTERASPARTATECHAGAS DISEASEGLUTAMATEMETABOLITE TRANSPORTTRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Aspartate is one of the compounds that induce the differentiation process of the non-infective epimastigote stage to the infective trypomastigote stage of the protozoan parasite Trypanosoma cruzi. l-aspartate is transported by both epimastigote and trypomastigote cells at the same rate, about 3.4 pmol min -1 per 107 cells. Aspartate transport is only competed by glutamate suggesting that this transport system is specific for anionic amino acids. Aspartate uptake rates increase along the parasite growth curve, by amino acids starvation or pH decrease. The metabolic fate of the transported aspartate was predicted in silico by identification of seven putative genes coding for enzymes involved in aspartate metabolism that could be related to the differentiation process.Fil: Canepa, Gaspar Exequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Bouvier, León Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Urias, Ursula. Universidade de Sao Paulo; BrasilFil: Miranda, Mariana Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Colli, W.. Universidade de Sao Paulo; BrasilFil: Alves, M.. Universidade de Sao Paulo; BrasilFil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaWiley Blackwell Publishing, Inc2005-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129442Canepa, Gaspar Exequiel; Bouvier, León Alberto; Urias, Ursula; Miranda, Mariana Reneé; Colli, W.; et al.; Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 247; 1; 6-2005; 65-710378-1097CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsle/article/247/1/65/535594info:eu-repo/semantics/altIdentifier/doi/10.1016/j.femsle.2005.04.029info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:43Zoai:ri.conicet.gov.ar:11336/129442instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:43.396CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
title Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
spellingShingle Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
Canepa, Gaspar Exequiel
AMINO ACID TRANSPORTER
ASPARTATE
CHAGAS DISEASE
GLUTAMATE
METABOLITE TRANSPORT
TRYPANOSOMA CRUZI
title_short Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
title_full Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
title_fullStr Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
title_full_unstemmed Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
title_sort Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi
dc.creator.none.fl_str_mv Canepa, Gaspar Exequiel
Bouvier, León Alberto
Urias, Ursula
Miranda, Mariana Reneé
Colli, W.
Alves, M.
Pereira, Claudio Alejandro
author Canepa, Gaspar Exequiel
author_facet Canepa, Gaspar Exequiel
Bouvier, León Alberto
Urias, Ursula
Miranda, Mariana Reneé
Colli, W.
Alves, M.
Pereira, Claudio Alejandro
author_role author
author2 Bouvier, León Alberto
Urias, Ursula
Miranda, Mariana Reneé
Colli, W.
Alves, M.
Pereira, Claudio Alejandro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AMINO ACID TRANSPORTER
ASPARTATE
CHAGAS DISEASE
GLUTAMATE
METABOLITE TRANSPORT
TRYPANOSOMA CRUZI
topic AMINO ACID TRANSPORTER
ASPARTATE
CHAGAS DISEASE
GLUTAMATE
METABOLITE TRANSPORT
TRYPANOSOMA CRUZI
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aspartate is one of the compounds that induce the differentiation process of the non-infective epimastigote stage to the infective trypomastigote stage of the protozoan parasite Trypanosoma cruzi. l-aspartate is transported by both epimastigote and trypomastigote cells at the same rate, about 3.4 pmol min -1 per 107 cells. Aspartate transport is only competed by glutamate suggesting that this transport system is specific for anionic amino acids. Aspartate uptake rates increase along the parasite growth curve, by amino acids starvation or pH decrease. The metabolic fate of the transported aspartate was predicted in silico by identification of seven putative genes coding for enzymes involved in aspartate metabolism that could be related to the differentiation process.
Fil: Canepa, Gaspar Exequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Bouvier, León Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Urias, Ursula. Universidade de Sao Paulo; Brasil
Fil: Miranda, Mariana Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Colli, W.. Universidade de Sao Paulo; Brasil
Fil: Alves, M.. Universidade de Sao Paulo; Brasil
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Aspartate is one of the compounds that induce the differentiation process of the non-infective epimastigote stage to the infective trypomastigote stage of the protozoan parasite Trypanosoma cruzi. l-aspartate is transported by both epimastigote and trypomastigote cells at the same rate, about 3.4 pmol min -1 per 107 cells. Aspartate transport is only competed by glutamate suggesting that this transport system is specific for anionic amino acids. Aspartate uptake rates increase along the parasite growth curve, by amino acids starvation or pH decrease. The metabolic fate of the transported aspartate was predicted in silico by identification of seven putative genes coding for enzymes involved in aspartate metabolism that could be related to the differentiation process.
publishDate 2005
dc.date.none.fl_str_mv 2005-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129442
Canepa, Gaspar Exequiel; Bouvier, León Alberto; Urias, Ursula; Miranda, Mariana Reneé; Colli, W.; et al.; Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 247; 1; 6-2005; 65-71
0378-1097
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129442
identifier_str_mv Canepa, Gaspar Exequiel; Bouvier, León Alberto; Urias, Ursula; Miranda, Mariana Reneé; Colli, W.; et al.; Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 247; 1; 6-2005; 65-71
0378-1097
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsle/article/247/1/65/535594
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.femsle.2005.04.029
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269770091593728
score 13.13397

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