Glycoconjugation: An approach to cancer therapeutics

Autores
Molejon, Maria Ines; Weiz, Gisela; Breccia, Javier Dario; Vaccaro, Maria Ines
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cancer constitutes the second leading cause of death globally and is consideredto have been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against gastrointestinal tumors have recently advanced, those interventions can only be applied to a minority of patients at the time ofdiagnosis. Therefore, new therapeutic options are necessary for advanced stagesof the disease. Glycosylation of antitumor agents, has been found to improvepharmacokinetic parameters, reduce side effects, and expand drug half-life incomparison with the parent compounds. In addition, glycosylation of therapeuticagents has been proven to be an effective strategy for their targeting tumor tissue, thereby reducing the doses of the glycodrugs administered to patients. This review focusses on the effect of the targeting properties of glycosylated antitumor agents on gastrointestinal tumors.
Fil: Molejon, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Weiz, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Breccia, Javier Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
GLYCOSYLATION
GASTROINTESTINAL CANCERS
ANTITUMORAL AGENTS
DRUG TARGETING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184105
Acceder
id CONICETDig_0f9cef4fab108be9f34d49fbd3ef0a1a
oai_identifier_str oai:ri.conicet.gov.ar:11336/184105
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Glycoconjugation: An approach to cancer therapeuticsMolejon, Maria InesWeiz, GiselaBreccia, Javier DarioVaccaro, Maria InesGLYCOSYLATIONGASTROINTESTINAL CANCERSANTITUMORAL AGENTSDRUG TARGETINGhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Cancer constitutes the second leading cause of death globally and is consideredto have been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against gastrointestinal tumors have recently advanced, those interventions can only be applied to a minority of patients at the time ofdiagnosis. Therefore, new therapeutic options are necessary for advanced stagesof the disease. Glycosylation of antitumor agents, has been found to improvepharmacokinetic parameters, reduce side effects, and expand drug half-life incomparison with the parent compounds. In addition, glycosylation of therapeuticagents has been proven to be an effective strategy for their targeting tumor tissue, thereby reducing the doses of the glycodrugs administered to patients. This review focusses on the effect of the targeting properties of glycosylated antitumor agents on gastrointestinal tumors.Fil: Molejon, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Weiz, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Breccia, Javier Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaBaishideng Publishing Group Inc.2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184105Molejon, Maria Ines; Weiz, Gisela; Breccia, Javier Dario; Vaccaro, Maria Ines; Glycoconjugation: An approach to cancer therapeutics; Baishideng Publishing Group Inc.; World Journal of Clinical Oncology; 11; 3; 3-2020; 110-1202218-4333CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2218-4333/full/v11/i3/110.htminfo:eu-repo/semantics/altIdentifier/doi/10.5306/wjco.v11.i3.110info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:13:37Zoai:ri.conicet.gov.ar:11336/184105instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:13:37.752CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glycoconjugation: An approach to cancer therapeutics
title Glycoconjugation: An approach to cancer therapeutics
spellingShingle Glycoconjugation: An approach to cancer therapeutics
Molejon, Maria Ines
GLYCOSYLATION
GASTROINTESTINAL CANCERS
ANTITUMORAL AGENTS
DRUG TARGETING
title_short Glycoconjugation: An approach to cancer therapeutics
title_full Glycoconjugation: An approach to cancer therapeutics
title_fullStr Glycoconjugation: An approach to cancer therapeutics
title_full_unstemmed Glycoconjugation: An approach to cancer therapeutics
title_sort Glycoconjugation: An approach to cancer therapeutics
dc.creator.none.fl_str_mv Molejon, Maria Ines
Weiz, Gisela
Breccia, Javier Dario
Vaccaro, Maria Ines
author Molejon, Maria Ines
author_facet Molejon, Maria Ines
Weiz, Gisela
Breccia, Javier Dario
Vaccaro, Maria Ines
author_role author
author2 Weiz, Gisela
Breccia, Javier Dario
Vaccaro, Maria Ines
author2_role author
author
author
dc.subject.none.fl_str_mv GLYCOSYLATION
GASTROINTESTINAL CANCERS
ANTITUMORAL AGENTS
DRUG TARGETING
topic GLYCOSYLATION
GASTROINTESTINAL CANCERS
ANTITUMORAL AGENTS
DRUG TARGETING
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Cancer constitutes the second leading cause of death globally and is consideredto have been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against gastrointestinal tumors have recently advanced, those interventions can only be applied to a minority of patients at the time ofdiagnosis. Therefore, new therapeutic options are necessary for advanced stagesof the disease. Glycosylation of antitumor agents, has been found to improvepharmacokinetic parameters, reduce side effects, and expand drug half-life incomparison with the parent compounds. In addition, glycosylation of therapeuticagents has been proven to be an effective strategy for their targeting tumor tissue, thereby reducing the doses of the glycodrugs administered to patients. This review focusses on the effect of the targeting properties of glycosylated antitumor agents on gastrointestinal tumors.
Fil: Molejon, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Weiz, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Breccia, Javier Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
description Cancer constitutes the second leading cause of death globally and is consideredto have been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against gastrointestinal tumors have recently advanced, those interventions can only be applied to a minority of patients at the time ofdiagnosis. Therefore, new therapeutic options are necessary for advanced stagesof the disease. Glycosylation of antitumor agents, has been found to improvepharmacokinetic parameters, reduce side effects, and expand drug half-life incomparison with the parent compounds. In addition, glycosylation of therapeuticagents has been proven to be an effective strategy for their targeting tumor tissue, thereby reducing the doses of the glycodrugs administered to patients. This review focusses on the effect of the targeting properties of glycosylated antitumor agents on gastrointestinal tumors.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184105
Molejon, Maria Ines; Weiz, Gisela; Breccia, Javier Dario; Vaccaro, Maria Ines; Glycoconjugation: An approach to cancer therapeutics; Baishideng Publishing Group Inc.; World Journal of Clinical Oncology; 11; 3; 3-2020; 110-120
2218-4333
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184105
identifier_str_mv Molejon, Maria Ines; Weiz, Gisela; Breccia, Javier Dario; Vaccaro, Maria Ines; Glycoconjugation: An approach to cancer therapeutics; Baishideng Publishing Group Inc.; World Journal of Clinical Oncology; 11; 3; 3-2020; 110-120
2218-4333
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2218-4333/full/v11/i3/110.htm
info:eu-repo/semantics/altIdentifier/doi/10.5306/wjco.v11.i3.110
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group Inc.
publisher.none.fl_str_mv Baishideng Publishing Group Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980721824628736
score 12.993085

Publicaciones similares