Antioxidant defenses, longevity and ecophysiology of South American bats
- Autores
- Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity.
Fil: Wilhelm Filho, Danilo. Universidade Federal de Santa Catarina; Brasil
Fil: Althoff, Sérgio Luiz. Universidade Federal de Santa Catarina; Brasil
Fil: Dafré, Alcir Luiz. Universidade Federal de Santa Catarina; Brasil
Fil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
ANTIOXIDANT DEFENSES
BATS
ECOPHYSIOLOGY
LONGEVITY
METABOLIC RATE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/162931
Ver los metadatos del registro completo
id |
CONICETDig_0f215b097bf44ff625a53adc153d547e |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/162931 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Antioxidant defenses, longevity and ecophysiology of South American batsWilhelm Filho, DaniloAlthoff, Sérgio LuizDafré, Alcir LuizBoveris, Alberto AntonioANTIOXIDANT DEFENSESBATSECOPHYSIOLOGYLONGEVITYMETABOLIC RATEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity.Fil: Wilhelm Filho, Danilo. Universidade Federal de Santa Catarina; BrasilFil: Althoff, Sérgio Luiz. Universidade Federal de Santa Catarina; BrasilFil: Dafré, Alcir Luiz. Universidade Federal de Santa Catarina; BrasilFil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science Inc.2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162931Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio; Antioxidant defenses, longevity and ecophysiology of South American bats; Elsevier Science Inc.; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 146; 1-2 SPEC. ISS.; 12-2007; 214-2201532-0456CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S153204560600278Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpc.2006.11.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:11Zoai:ri.conicet.gov.ar:11336/162931instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:12.187CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Antioxidant defenses, longevity and ecophysiology of South American bats |
title |
Antioxidant defenses, longevity and ecophysiology of South American bats |
spellingShingle |
Antioxidant defenses, longevity and ecophysiology of South American bats Wilhelm Filho, Danilo ANTIOXIDANT DEFENSES BATS ECOPHYSIOLOGY LONGEVITY METABOLIC RATE |
title_short |
Antioxidant defenses, longevity and ecophysiology of South American bats |
title_full |
Antioxidant defenses, longevity and ecophysiology of South American bats |
title_fullStr |
Antioxidant defenses, longevity and ecophysiology of South American bats |
title_full_unstemmed |
Antioxidant defenses, longevity and ecophysiology of South American bats |
title_sort |
Antioxidant defenses, longevity and ecophysiology of South American bats |
dc.creator.none.fl_str_mv |
Wilhelm Filho, Danilo Althoff, Sérgio Luiz Dafré, Alcir Luiz Boveris, Alberto Antonio |
author |
Wilhelm Filho, Danilo |
author_facet |
Wilhelm Filho, Danilo Althoff, Sérgio Luiz Dafré, Alcir Luiz Boveris, Alberto Antonio |
author_role |
author |
author2 |
Althoff, Sérgio Luiz Dafré, Alcir Luiz Boveris, Alberto Antonio |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
ANTIOXIDANT DEFENSES BATS ECOPHYSIOLOGY LONGEVITY METABOLIC RATE |
topic |
ANTIOXIDANT DEFENSES BATS ECOPHYSIOLOGY LONGEVITY METABOLIC RATE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity. Fil: Wilhelm Filho, Danilo. Universidade Federal de Santa Catarina; Brasil Fil: Althoff, Sérgio Luiz. Universidade Federal de Santa Catarina; Brasil Fil: Dafré, Alcir Luiz. Universidade Federal de Santa Catarina; Brasil Fil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/162931 Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio; Antioxidant defenses, longevity and ecophysiology of South American bats; Elsevier Science Inc.; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 146; 1-2 SPEC. ISS.; 12-2007; 214-220 1532-0456 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/162931 |
identifier_str_mv |
Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio; Antioxidant defenses, longevity and ecophysiology of South American bats; Elsevier Science Inc.; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 146; 1-2 SPEC. ISS.; 12-2007; 214-220 1532-0456 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S153204560600278X info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpc.2006.11.015 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science Inc. |
publisher.none.fl_str_mv |
Elsevier Science Inc. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613302217342976 |
score |
13.070432 |