Antioxidant defenses, longevity and ecophysiology of South American bats

Autores
Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity.
Fil: Wilhelm Filho, Danilo. Universidade Federal de Santa Catarina; Brasil
Fil: Althoff, Sérgio Luiz. Universidade Federal de Santa Catarina; Brasil
Fil: Dafré, Alcir Luiz. Universidade Federal de Santa Catarina; Brasil
Fil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANTIOXIDANT DEFENSES
BATS
ECOPHYSIOLOGY
LONGEVITY
METABOLIC RATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162931
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/162931
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antioxidant defenses, longevity and ecophysiology of South American batsWilhelm Filho, DaniloAlthoff, Sérgio LuizDafré, Alcir LuizBoveris, Alberto AntonioANTIOXIDANT DEFENSESBATSECOPHYSIOLOGYLONGEVITYMETABOLIC RATEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity.Fil: Wilhelm Filho, Danilo. Universidade Federal de Santa Catarina; BrasilFil: Althoff, Sérgio Luiz. Universidade Federal de Santa Catarina; BrasilFil: Dafré, Alcir Luiz. Universidade Federal de Santa Catarina; BrasilFil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science Inc.2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162931Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio; Antioxidant defenses, longevity and ecophysiology of South American bats; Elsevier Science Inc.; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 146; 1-2 SPEC. ISS.; 12-2007; 214-2201532-0456CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S153204560600278Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpc.2006.11.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:09:47Zoai:ri.conicet.gov.ar:11336/162931instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:09:48.254CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antioxidant defenses, longevity and ecophysiology of South American bats
title Antioxidant defenses, longevity and ecophysiology of South American bats
spellingShingle Antioxidant defenses, longevity and ecophysiology of South American bats
Wilhelm Filho, Danilo
ANTIOXIDANT DEFENSES
BATS
ECOPHYSIOLOGY
LONGEVITY
METABOLIC RATE
title_short Antioxidant defenses, longevity and ecophysiology of South American bats
title_full Antioxidant defenses, longevity and ecophysiology of South American bats
title_fullStr Antioxidant defenses, longevity and ecophysiology of South American bats
title_full_unstemmed Antioxidant defenses, longevity and ecophysiology of South American bats
title_sort Antioxidant defenses, longevity and ecophysiology of South American bats
dc.creator.none.fl_str_mv Wilhelm Filho, Danilo
Althoff, Sérgio Luiz
Dafré, Alcir Luiz
Boveris, Alberto Antonio
author Wilhelm Filho, Danilo
author_facet Wilhelm Filho, Danilo
Althoff, Sérgio Luiz
Dafré, Alcir Luiz
Boveris, Alberto Antonio
author_role author
author2 Althoff, Sérgio Luiz
Dafré, Alcir Luiz
Boveris, Alberto Antonio
author2_role author
author
author
dc.subject.none.fl_str_mv ANTIOXIDANT DEFENSES
BATS
ECOPHYSIOLOGY
LONGEVITY
METABOLIC RATE
topic ANTIOXIDANT DEFENSES
BATS
ECOPHYSIOLOGY
LONGEVITY
METABOLIC RATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity.
Fil: Wilhelm Filho, Danilo. Universidade Federal de Santa Catarina; Brasil
Fil: Althoff, Sérgio Luiz. Universidade Federal de Santa Catarina; Brasil
Fil: Dafré, Alcir Luiz. Universidade Federal de Santa Catarina; Brasil
Fil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In addition, bats are also characterized by an extraordinary longevity considering their body mass and high specific metabolic rate when compared to other mammals of related size. Therefore, they consist of a very interesting group regarding the free radical theory of aging. The present study was carried out to measure the antioxidant defenses of several tissues of five South American bat species, attempting to correlate the antioxidant status, ecophysiology and longevity. Superoxide dismutase (SOD) and catalase (CAT) activities in blood, liver and kidney were higher compared to other tissues. The contents of alpha-tocopherol and beta-carotene found in liver, heart, kidneys, and pectoral muscles were one to two orders of magnitude higher than those usually found in rat and mouse liver. Also, these contents in liver were generally inversely related to lipoperoxidation measured as TBARS contents. Blood GSH contents and the activities of SOD and CAT were higher in torpid Sturnira lillium compared to active ones, thus suggesting that the elevation of such antioxidants might be daily modulated to minimize the oxidative stress related to the transition from torpid to active state in bats. The lower ROS generation reported in the literature for other bat species, their high constitutive antioxidant defenses, and the daily energy sparing associated with torpor appear to be closely related to their ecophysiological adaptations and to their extended longevity.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162931
Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio; Antioxidant defenses, longevity and ecophysiology of South American bats; Elsevier Science Inc.; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 146; 1-2 SPEC. ISS.; 12-2007; 214-220
1532-0456
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162931
identifier_str_mv Wilhelm Filho, Danilo; Althoff, Sérgio Luiz; Dafré, Alcir Luiz; Boveris, Alberto Antonio; Antioxidant defenses, longevity and ecophysiology of South American bats; Elsevier Science Inc.; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 146; 1-2 SPEC. ISS.; 12-2007; 214-220
1532-0456
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S153204560600278X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpc.2006.11.015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781450067640320
score 12.982451

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