Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability

Autores
Campos, Cristina; Rabello Casali, Karina; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; Khaper, Neelam; Llesuy, Susana Francisca; Rigatto, Katya; Belló Klein, Adriane
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.
Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Rabello Casali, Karina. Instituto de Cardiologia do Rio Grande do Sul; Brasil
Fil: Baraldi, Dhãniel. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Conzatti, Adriana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Rosa Araújo, Alex Sander da. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Khaper, Neelam. Lakehead University; Canadá
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Rigatto, Katya. Universidade Federal de Ciências da Saúde de Porto Alegre; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Materia
Estrogen
Antioxidant defenses
Heart rate variability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30296

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network_name_str CONICET Digital (CONICET)
spelling Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate VariabilityCampos, CristinaRabello Casali, KarinaBaraldi, DhãnielConzatti, AdrianaRosa Araújo, Alex Sander daKhaper, NeelamLlesuy, Susana FranciscaRigatto, KatyaBelló Klein, AdrianeEstrogenAntioxidant defensesHeart rate variabilityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; BrasilFil: Rabello Casali, Karina. Instituto de Cardiologia do Rio Grande do Sul; BrasilFil: Baraldi, Dhãniel. Universidade Federal do Rio Grande do Sul; BrasilFil: Conzatti, Adriana. Universidade Federal do Rio Grande do Sul; BrasilFil: Rosa Araújo, Alex Sander da. Universidade Federal do Rio Grande do Sul; BrasilFil: Khaper, Neelam. Lakehead University; CanadáFil: Llesuy, Susana Francisca. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Rigatto, Katya. Universidade Federal de Ciências da Saúde de Porto Alegre; BrasilFil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilHindawi Publishing Corporation2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30296Campos, Cristina; Rabello Casali, Karina ; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; et al.; Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2014; 3-2014; 1-7; 2187491942-09001942-0994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2014/218749/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/218749info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:21Zoai:ri.conicet.gov.ar:11336/30296instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:21.906CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
title Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
spellingShingle Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
Campos, Cristina
Estrogen
Antioxidant defenses
Heart rate variability
title_short Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
title_full Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
title_fullStr Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
title_full_unstemmed Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
title_sort Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
dc.creator.none.fl_str_mv Campos, Cristina
Rabello Casali, Karina
Baraldi, Dhãniel
Conzatti, Adriana
Rosa Araújo, Alex Sander da
Khaper, Neelam
Llesuy, Susana Francisca
Rigatto, Katya
Belló Klein, Adriane
author Campos, Cristina
author_facet Campos, Cristina
Rabello Casali, Karina
Baraldi, Dhãniel
Conzatti, Adriana
Rosa Araújo, Alex Sander da
Khaper, Neelam
Llesuy, Susana Francisca
Rigatto, Katya
Belló Klein, Adriane
author_role author
author2 Rabello Casali, Karina
Baraldi, Dhãniel
Conzatti, Adriana
Rosa Araújo, Alex Sander da
Khaper, Neelam
Llesuy, Susana Francisca
Rigatto, Katya
Belló Klein, Adriane
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Estrogen
Antioxidant defenses
Heart rate variability
topic Estrogen
Antioxidant defenses
Heart rate variability
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.
Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Rabello Casali, Karina. Instituto de Cardiologia do Rio Grande do Sul; Brasil
Fil: Baraldi, Dhãniel. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Conzatti, Adriana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Rosa Araújo, Alex Sander da. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Khaper, Neelam. Lakehead University; Canadá
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Rigatto, Katya. Universidade Federal de Ciências da Saúde de Porto Alegre; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
description This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30296
Campos, Cristina; Rabello Casali, Karina ; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; et al.; Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2014; 3-2014; 1-7; 218749
1942-0900
1942-0994
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30296
identifier_str_mv Campos, Cristina; Rabello Casali, Karina ; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; et al.; Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2014; 3-2014; 1-7; 218749
1942-0900
1942-0994
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2014/218749/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/218749
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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