Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
- Autores
- Campos, Cristina; Rabello Casali, Karina; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; Khaper, Neelam; Llesuy, Susana Francisca; Rigatto, Katya; Belló Klein, Adriane
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.
Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Rabello Casali, Karina. Instituto de Cardiologia do Rio Grande do Sul; Brasil
Fil: Baraldi, Dhãniel. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Conzatti, Adriana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Rosa Araújo, Alex Sander da. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Khaper, Neelam. Lakehead University; Canadá
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Rigatto, Katya. Universidade Federal de Ciências da Saúde de Porto Alegre; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil - Materia
-
Estrogen
Antioxidant defenses
Heart rate variability - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/30296
Ver los metadatos del registro completo
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Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate VariabilityCampos, CristinaRabello Casali, KarinaBaraldi, DhãnielConzatti, AdrianaRosa Araújo, Alex Sander daKhaper, NeelamLlesuy, Susana FranciscaRigatto, KatyaBelló Klein, AdrianeEstrogenAntioxidant defensesHeart rate variabilityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; BrasilFil: Rabello Casali, Karina. Instituto de Cardiologia do Rio Grande do Sul; BrasilFil: Baraldi, Dhãniel. Universidade Federal do Rio Grande do Sul; BrasilFil: Conzatti, Adriana. Universidade Federal do Rio Grande do Sul; BrasilFil: Rosa Araújo, Alex Sander da. Universidade Federal do Rio Grande do Sul; BrasilFil: Khaper, Neelam. Lakehead University; CanadáFil: Llesuy, Susana Francisca. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Rigatto, Katya. Universidade Federal de Ciências da Saúde de Porto Alegre; BrasilFil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilHindawi Publishing Corporation2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30296Campos, Cristina; Rabello Casali, Karina ; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; et al.; Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2014; 3-2014; 1-7; 2187491942-09001942-0994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2014/218749/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/218749info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:21Zoai:ri.conicet.gov.ar:11336/30296instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:21.906CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
title |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
spellingShingle |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability Campos, Cristina Estrogen Antioxidant defenses Heart rate variability |
title_short |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
title_full |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
title_fullStr |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
title_full_unstemmed |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
title_sort |
Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability |
dc.creator.none.fl_str_mv |
Campos, Cristina Rabello Casali, Karina Baraldi, Dhãniel Conzatti, Adriana Rosa Araújo, Alex Sander da Khaper, Neelam Llesuy, Susana Francisca Rigatto, Katya Belló Klein, Adriane |
author |
Campos, Cristina |
author_facet |
Campos, Cristina Rabello Casali, Karina Baraldi, Dhãniel Conzatti, Adriana Rosa Araújo, Alex Sander da Khaper, Neelam Llesuy, Susana Francisca Rigatto, Katya Belló Klein, Adriane |
author_role |
author |
author2 |
Rabello Casali, Karina Baraldi, Dhãniel Conzatti, Adriana Rosa Araújo, Alex Sander da Khaper, Neelam Llesuy, Susana Francisca Rigatto, Katya Belló Klein, Adriane |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Estrogen Antioxidant defenses Heart rate variability |
topic |
Estrogen Antioxidant defenses Heart rate variability |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy. Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; Brasil Fil: Rabello Casali, Karina. Instituto de Cardiologia do Rio Grande do Sul; Brasil Fil: Baraldi, Dhãniel. Universidade Federal do Rio Grande do Sul; Brasil Fil: Conzatti, Adriana. Universidade Federal do Rio Grande do Sul; Brasil Fil: Rosa Araújo, Alex Sander da. Universidade Federal do Rio Grande do Sul; Brasil Fil: Khaper, Neelam. Lakehead University; Canadá Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina Fil: Rigatto, Katya. Universidade Federal de Ciências da Saúde de Porto Alegre; Brasil Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil |
description |
This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress. Female Wistar rats (n = 9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously. Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed. Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured. HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability. These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT. A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group. Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/30296 Campos, Cristina; Rabello Casali, Karina ; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; et al.; Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2014; 3-2014; 1-7; 218749 1942-0900 1942-0994 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/30296 |
identifier_str_mv |
Campos, Cristina; Rabello Casali, Karina ; Baraldi, Dhãniel; Conzatti, Adriana; Rosa Araújo, Alex Sander da; et al.; Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2014; 3-2014; 1-7; 218749 1942-0900 1942-0994 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2014/218749/ info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/218749 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613306650722304 |
score |
13.070432 |