A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area

Autores
Gelman, Diego Matias; Griveau, Amelie; Dehorter, Nathalie; Teissier, Anne; Varela, Carolina; Pla, Ramon; Pierani, Alessandra; Marin, Oscar
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE- or CGE-derived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE- or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse.
Fil: Gelman, Diego Matias. Universidad Miguel Hernández; España. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Griveau, Amelie. Universite Paris Diderot - Paris 7; Francia
Fil: Dehorter, Nathalie. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Fil: Teissier, Anne. Universite Paris Diderot - Paris 7; Francia
Fil: Varela, Carolina. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Fil: Pla, Ramon. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Fil: Pierani, Alessandra. Universite Paris Diderot - Paris 7; Francia
Fil: Marin, Oscar. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Materia
PREOPTIC AREA
INTERNEURON
SOURCE
ORIGIN
GENE EXPRESSION REGULATION
NEURAL STEM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14111
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14111
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic areaGelman, Diego MatiasGriveau, AmelieDehorter, NathalieTeissier, AnneVarela, CarolinaPla, RamonPierani, AlessandraMarin, OscarPREOPTIC AREAINTERNEURONSOURCEORIGINGENE EXPRESSION REGULATIONNEURAL STEMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE- or CGE-derived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE- or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse.Fil: Gelman, Diego Matias. Universidad Miguel Hernández; España. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Griveau, Amelie. Universite Paris Diderot - Paris 7; FranciaFil: Dehorter, Nathalie. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaFil: Teissier, Anne. Universite Paris Diderot - Paris 7; FranciaFil: Varela, Carolina. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaFil: Pla, Ramon. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaFil: Pierani, Alessandra. Universite Paris Diderot - Paris 7; FranciaFil: Marin, Oscar. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; EspañaSociety For Neuroscience2011-11-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14111Gelman, Diego Matias; Griveau, Amelie; Dehorter, Nathalie; Teissier, Anne; Varela, Carolina; et al.; A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area; Society For Neuroscience; Journal Of Neuroscience; 31; 46; 16-11-2011; 16570-165800270-64741529-2401enginfo:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/31/46/16570info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.4068-11.2011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:14:26Zoai:ri.conicet.gov.ar:11336/14111instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:14:26.374CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
title A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
spellingShingle A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
Gelman, Diego Matias
PREOPTIC AREA
INTERNEURON
SOURCE
ORIGIN
GENE EXPRESSION REGULATION
NEURAL STEM
title_short A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
title_full A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
title_fullStr A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
title_full_unstemmed A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
title_sort A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
dc.creator.none.fl_str_mv Gelman, Diego Matias
Griveau, Amelie
Dehorter, Nathalie
Teissier, Anne
Varela, Carolina
Pla, Ramon
Pierani, Alessandra
Marin, Oscar
author Gelman, Diego Matias
author_facet Gelman, Diego Matias
Griveau, Amelie
Dehorter, Nathalie
Teissier, Anne
Varela, Carolina
Pla, Ramon
Pierani, Alessandra
Marin, Oscar
author_role author
author2 Griveau, Amelie
Dehorter, Nathalie
Teissier, Anne
Varela, Carolina
Pla, Ramon
Pierani, Alessandra
Marin, Oscar
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PREOPTIC AREA
INTERNEURON
SOURCE
ORIGIN
GENE EXPRESSION REGULATION
NEURAL STEM
topic PREOPTIC AREA
INTERNEURON
SOURCE
ORIGIN
GENE EXPRESSION REGULATION
NEURAL STEM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE- or CGE-derived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE- or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse.
Fil: Gelman, Diego Matias. Universidad Miguel Hernández; España. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Griveau, Amelie. Universite Paris Diderot - Paris 7; Francia
Fil: Dehorter, Nathalie. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Fil: Teissier, Anne. Universite Paris Diderot - Paris 7; Francia
Fil: Varela, Carolina. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Fil: Pla, Ramon. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
Fil: Pierani, Alessandra. Universite Paris Diderot - Paris 7; Francia
Fil: Marin, Oscar. Consejo Superior de Investigaciones Cientificas. Instituto de Neurociencia de Alicante; España. Universidad Miguel Hernández; España
description GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE- or CGE-derived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE- or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-16
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14111
Gelman, Diego Matias; Griveau, Amelie; Dehorter, Nathalie; Teissier, Anne; Varela, Carolina; et al.; A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area; Society For Neuroscience; Journal Of Neuroscience; 31; 46; 16-11-2011; 16570-16580
0270-6474
1529-2401
url http://hdl.handle.net/11336/14111
identifier_str_mv Gelman, Diego Matias; Griveau, Amelie; Dehorter, Nathalie; Teissier, Anne; Varela, Carolina; et al.; A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area; Society For Neuroscience; Journal Of Neuroscience; 31; 46; 16-11-2011; 16570-16580
0270-6474
1529-2401
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/31/46/16570
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.4068-11.2011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society For Neuroscience
publisher.none.fl_str_mv Society For Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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