The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium

Autores
Pescaretti, María de Las Mercedes; Lopez, Fabian Enrique; Morero, Roberto Dionisio; Delgado, Monica Alejandra
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The degree of polymerization of O-antigen from Salmonella enterica serovar Typhimurium is controlled by the products of the wzz st and wzz fepE genes. In the present study we investigated the role of the PmrA/PmrB regulatory system in wzz fepE transcription. We report that the direct binding of the PmrA regulator to a specific promoter site induces the expression of the wzz fepE gene. This effect increases the amount of very long (VL) O-antigen, which is required for the resistance of Salmonella to serum human complement and polymyxin B, and for the replication of the bacteria within macrophages. The results obtained here highlight functional differences between Wzz fepE and Wzz st, although the genes for both proteins are regulated in a PmrA-dependent way.
Fil: Pescaretti, María de Las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Lopez, Fabian Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Materia
Salmonella
Antigeno O
Expresion Genica
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/62825
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar TyphimuriumPescaretti, María de Las MercedesLopez, Fabian EnriqueMorero, Roberto DionisioDelgado, Monica AlejandraSalmonellaAntigeno OExpresion Genicahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The degree of polymerization of O-antigen from Salmonella enterica serovar Typhimurium is controlled by the products of the wzz st and wzz fepE genes. In the present study we investigated the role of the PmrA/PmrB regulatory system in wzz fepE transcription. We report that the direct binding of the PmrA regulator to a specific promoter site induces the expression of the wzz fepE gene. This effect increases the amount of very long (VL) O-antigen, which is required for the resistance of Salmonella to serum human complement and polymyxin B, and for the replication of the bacteria within macrophages. The results obtained here highlight functional differences between Wzz fepE and Wzz st, although the genes for both proteins are regulated in a PmrA-dependent way.Fil: Pescaretti, María de Las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Lopez, Fabian Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaSociety for General Microbiology2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/62825Pescaretti, María de Las Mercedes; Lopez, Fabian Enrique; Morero, Roberto Dionisio; Delgado, Monica Alejandra; The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium; Society for General Microbiology; Microbiology-UK; 157; 9; 9-2011; 2515-25211350-0872CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.050088-0info:eu-repo/semantics/altIdentifier/doi/10.1099/mic.0.050088-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:14:38Zoai:ri.conicet.gov.ar:11336/62825instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:14:39.244CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
title The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
spellingShingle The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
Pescaretti, María de Las Mercedes
Salmonella
Antigeno O
Expresion Genica
title_short The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
title_full The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
title_fullStr The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
title_full_unstemmed The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
title_sort The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium
dc.creator.none.fl_str_mv Pescaretti, María de Las Mercedes
Lopez, Fabian Enrique
Morero, Roberto Dionisio
Delgado, Monica Alejandra
author Pescaretti, María de Las Mercedes
author_facet Pescaretti, María de Las Mercedes
Lopez, Fabian Enrique
Morero, Roberto Dionisio
Delgado, Monica Alejandra
author_role author
author2 Lopez, Fabian Enrique
Morero, Roberto Dionisio
Delgado, Monica Alejandra
author2_role author
author
author
dc.subject.none.fl_str_mv Salmonella
Antigeno O
Expresion Genica
topic Salmonella
Antigeno O
Expresion Genica
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The degree of polymerization of O-antigen from Salmonella enterica serovar Typhimurium is controlled by the products of the wzz st and wzz fepE genes. In the present study we investigated the role of the PmrA/PmrB regulatory system in wzz fepE transcription. We report that the direct binding of the PmrA regulator to a specific promoter site induces the expression of the wzz fepE gene. This effect increases the amount of very long (VL) O-antigen, which is required for the resistance of Salmonella to serum human complement and polymyxin B, and for the replication of the bacteria within macrophages. The results obtained here highlight functional differences between Wzz fepE and Wzz st, although the genes for both proteins are regulated in a PmrA-dependent way.
Fil: Pescaretti, María de Las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Lopez, Fabian Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
description The degree of polymerization of O-antigen from Salmonella enterica serovar Typhimurium is controlled by the products of the wzz st and wzz fepE genes. In the present study we investigated the role of the PmrA/PmrB regulatory system in wzz fepE transcription. We report that the direct binding of the PmrA regulator to a specific promoter site induces the expression of the wzz fepE gene. This effect increases the amount of very long (VL) O-antigen, which is required for the resistance of Salmonella to serum human complement and polymyxin B, and for the replication of the bacteria within macrophages. The results obtained here highlight functional differences between Wzz fepE and Wzz st, although the genes for both proteins are regulated in a PmrA-dependent way.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/62825
Pescaretti, María de Las Mercedes; Lopez, Fabian Enrique; Morero, Roberto Dionisio; Delgado, Monica Alejandra; The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium; Society for General Microbiology; Microbiology-UK; 157; 9; 9-2011; 2515-2521
1350-0872
CONICET Digital
CONICET
url http://hdl.handle.net/11336/62825
identifier_str_mv Pescaretti, María de Las Mercedes; Lopez, Fabian Enrique; Morero, Roberto Dionisio; Delgado, Monica Alejandra; The PmrA/PmrB regulatory system controls the expression of the wzz fepE gene involved in the O-antigen synthesis of Salmonella enterica serovar Typhimurium; Society for General Microbiology; Microbiology-UK; 157; 9; 9-2011; 2515-2521
1350-0872
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.050088-0
info:eu-repo/semantics/altIdentifier/doi/10.1099/mic.0.050088-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for General Microbiology
publisher.none.fl_str_mv Society for General Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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