Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design

Autores
González, Exequiel Elías; Cerúsico, Nicolás Abel; Moreno, María Julieta; Sesto Cabral, María Eugenia
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Materials from bio-based resources have attracted immense research interest in recent years as a result of their very high potentials for fabricating several high-value products with low impact on the environment. Cellulose produced by some bacteria has received great attention. Bacterial Nano Cellulose (BNC) imparts attractive combinations of biophysicochemical characteristics and improved mechanical properties. The aims of this work was to develop growth media for increase BNC production, characterize a non-active pharmaceutical ingredient (NAPI), design an efficient quality control method by FTIR and SEM by compared that NAPI with commercial ones and present a first prototype of a pharmaceutical product. LB and KB media were modified and BNC obtained had better quality respect its crystallinity and/or polymerization degree than the BNC from commercial media. Different extraction processes were proposed, in no case microbiological material remnants has been found. Films for controlled drugs release prototype were made and its physical properties such as water solubility, moisture content, swelling property, UV barrier capacity were evaluated. BNC films present an additional advantage, having lower UV permeability than films with cellulose of vegetal origin, adding potentialities to a patch design that protects the tissue and the Active Pharmaceutical Ingredients.
Fil: González, Exequiel Elías. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Cerúsico, Nicolás Abel. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Moreno, María Julieta. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Materia
BACTERIAL NANO CELLULOSE
QUALITY CONTROL
FTIR SPECTROSCOPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115221
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/115221
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype designGonzález, Exequiel ElíasCerúsico, Nicolás AbelMoreno, María JulietaSesto Cabral, María EugeniaBACTERIAL NANO CELLULOSEQUALITY CONTROLFTIR SPECTROSCOPYhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Materials from bio-based resources have attracted immense research interest in recent years as a result of their very high potentials for fabricating several high-value products with low impact on the environment. Cellulose produced by some bacteria has received great attention. Bacterial Nano Cellulose (BNC) imparts attractive combinations of biophysicochemical characteristics and improved mechanical properties. The aims of this work was to develop growth media for increase BNC production, characterize a non-active pharmaceutical ingredient (NAPI), design an efficient quality control method by FTIR and SEM by compared that NAPI with commercial ones and present a first prototype of a pharmaceutical product. LB and KB media were modified and BNC obtained had better quality respect its crystallinity and/or polymerization degree than the BNC from commercial media. Different extraction processes were proposed, in no case microbiological material remnants has been found. Films for controlled drugs release prototype were made and its physical properties such as water solubility, moisture content, swelling property, UV barrier capacity were evaluated. BNC films present an additional advantage, having lower UV permeability than films with cellulose of vegetal origin, adding potentialities to a patch design that protects the tissue and the Active Pharmaceutical Ingredients.Fil: González, Exequiel Elías. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; ArgentinaFil: Cerúsico, Nicolás Abel. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; ArgentinaFil: Moreno, María Julieta. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; ArgentinaFil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; ArgentinaMedCrave2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115221González, Exequiel Elías; Cerúsico, Nicolás Abel; Moreno, María Julieta; Sesto Cabral, María Eugenia; Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design; MedCrave; Drug Design Development and Therapy; 3; 2; 3-2019; 35-442575-9094CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medcrave.org/index.php/MOJDDT/article/view/14930info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:35Zoai:ri.conicet.gov.ar:11336/115221instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:36.22CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
title Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
spellingShingle Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
González, Exequiel Elías
BACTERIAL NANO CELLULOSE
QUALITY CONTROL
FTIR SPECTROSCOPY
title_short Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
title_full Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
title_fullStr Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
title_full_unstemmed Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
title_sort Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design
dc.creator.none.fl_str_mv González, Exequiel Elías
Cerúsico, Nicolás Abel
Moreno, María Julieta
Sesto Cabral, María Eugenia
author González, Exequiel Elías
author_facet González, Exequiel Elías
Cerúsico, Nicolás Abel
Moreno, María Julieta
Sesto Cabral, María Eugenia
author_role author
author2 Cerúsico, Nicolás Abel
Moreno, María Julieta
Sesto Cabral, María Eugenia
author2_role author
author
author
dc.subject.none.fl_str_mv BACTERIAL NANO CELLULOSE
QUALITY CONTROL
FTIR SPECTROSCOPY
topic BACTERIAL NANO CELLULOSE
QUALITY CONTROL
FTIR SPECTROSCOPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Materials from bio-based resources have attracted immense research interest in recent years as a result of their very high potentials for fabricating several high-value products with low impact on the environment. Cellulose produced by some bacteria has received great attention. Bacterial Nano Cellulose (BNC) imparts attractive combinations of biophysicochemical characteristics and improved mechanical properties. The aims of this work was to develop growth media for increase BNC production, characterize a non-active pharmaceutical ingredient (NAPI), design an efficient quality control method by FTIR and SEM by compared that NAPI with commercial ones and present a first prototype of a pharmaceutical product. LB and KB media were modified and BNC obtained had better quality respect its crystallinity and/or polymerization degree than the BNC from commercial media. Different extraction processes were proposed, in no case microbiological material remnants has been found. Films for controlled drugs release prototype were made and its physical properties such as water solubility, moisture content, swelling property, UV barrier capacity were evaluated. BNC films present an additional advantage, having lower UV permeability than films with cellulose of vegetal origin, adding potentialities to a patch design that protects the tissue and the Active Pharmaceutical Ingredients.
Fil: González, Exequiel Elías. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Cerúsico, Nicolás Abel. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Moreno, María Julieta. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
description Materials from bio-based resources have attracted immense research interest in recent years as a result of their very high potentials for fabricating several high-value products with low impact on the environment. Cellulose produced by some bacteria has received great attention. Bacterial Nano Cellulose (BNC) imparts attractive combinations of biophysicochemical characteristics and improved mechanical properties. The aims of this work was to develop growth media for increase BNC production, characterize a non-active pharmaceutical ingredient (NAPI), design an efficient quality control method by FTIR and SEM by compared that NAPI with commercial ones and present a first prototype of a pharmaceutical product. LB and KB media were modified and BNC obtained had better quality respect its crystallinity and/or polymerization degree than the BNC from commercial media. Different extraction processes were proposed, in no case microbiological material remnants has been found. Films for controlled drugs release prototype were made and its physical properties such as water solubility, moisture content, swelling property, UV barrier capacity were evaluated. BNC films present an additional advantage, having lower UV permeability than films with cellulose of vegetal origin, adding potentialities to a patch design that protects the tissue and the Active Pharmaceutical Ingredients.
publishDate 2019
dc.date.none.fl_str_mv 2019-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115221
González, Exequiel Elías; Cerúsico, Nicolás Abel; Moreno, María Julieta; Sesto Cabral, María Eugenia; Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design; MedCrave; Drug Design Development and Therapy; 3; 2; 3-2019; 35-44
2575-9094
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115221
identifier_str_mv González, Exequiel Elías; Cerúsico, Nicolás Abel; Moreno, María Julieta; Sesto Cabral, María Eugenia; Bacterial nano cellullose as non-active pharmaceutical ingredient production optimization, quality control development and prototype design; MedCrave; Drug Design Development and Therapy; 3; 2; 3-2019; 35-44
2575-9094
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.medcrave.org/index.php/MOJDDT/article/view/14930
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MedCrave
publisher.none.fl_str_mv MedCrave
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270008484298752
score 13.13397

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