Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.

Autores
González, Exequiel Elías; Sesto Cabral, María Eugenia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bacterial Nano Cellulose (BNC) is a primary metabolite synthesized inside Pseudomonas fluorecens bacterial cell. BNC has distinctive characteristics that introduces modifications in its biological and physicochemical properties. Its swelling capacity under special conditions make it an unique model for semi-solid topical pharmaceutical forms design. Cleaner production studies developed in our laboratory demonstrate that it is possible to reduce the concentration of synthetic excipients in gel formulas with the addition of small concentrations of BNC. This work shows our experience in the redesign of the base formula for semi-solid gels, its implementation on the manufacture of a natural mosquito repelent, and a joint experience with a rural school and its comunity in Amberes-Tucuman-Argentina. The primary health care center (CAPS- Comuna de Amberes) provided alarming data regarding the prevalence of dengue virus, which is endemic in the area due to its geographical location. To the natural active pharmaceutical ingredient selection, aromatic plants from the area that contain citronellol and/or limonene in high concentrations were surveyed. Cymbopogon citratus, was selected, due to its abundance in the Amberes área. Safety evaluation and persitence studies of the repellent action were carried out on 100 healthy volunteers from Amberes commune.
Fil: González, Exequiel Elías. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Materia
BACTERIAL NANOCELLULOSE
MOSQUITO REPELENT
TOPICAL FORMULATION
NATURAL PRODUCTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256863
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.González, Exequiel ElíasSesto Cabral, María EugeniaBACTERIAL NANOCELLULOSEMOSQUITO REPELENTTOPICAL FORMULATIONNATURAL PRODUCTShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Bacterial Nano Cellulose (BNC) is a primary metabolite synthesized inside Pseudomonas fluorecens bacterial cell. BNC has distinctive characteristics that introduces modifications in its biological and physicochemical properties. Its swelling capacity under special conditions make it an unique model for semi-solid topical pharmaceutical forms design. Cleaner production studies developed in our laboratory demonstrate that it is possible to reduce the concentration of synthetic excipients in gel formulas with the addition of small concentrations of BNC. This work shows our experience in the redesign of the base formula for semi-solid gels, its implementation on the manufacture of a natural mosquito repelent, and a joint experience with a rural school and its comunity in Amberes-Tucuman-Argentina. The primary health care center (CAPS- Comuna de Amberes) provided alarming data regarding the prevalence of dengue virus, which is endemic in the area due to its geographical location. To the natural active pharmaceutical ingredient selection, aromatic plants from the area that contain citronellol and/or limonene in high concentrations were surveyed. Cymbopogon citratus, was selected, due to its abundance in the Amberes área. Safety evaluation and persitence studies of the repellent action were carried out on 100 healthy volunteers from Amberes commune.Fil: González, Exequiel Elías. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; ArgentinaFil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; ArgentinaSalient Visionary Publication2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256863González, Exequiel Elías; Sesto Cabral, María Eugenia; Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.; Salient Visionary Publication; International Clinical and Medical Case Reports Journal; 18; 12-2023; 1-152832-5788CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://zenodo.org/records/10340001info:eu-repo/semantics/altIdentifier/doi/10.5281/zenodo.10340000info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:35Zoai:ri.conicet.gov.ar:11336/256863instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:36.198CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
title Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
spellingShingle Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
González, Exequiel Elías
BACTERIAL NANOCELLULOSE
MOSQUITO REPELENT
TOPICAL FORMULATION
NATURAL PRODUCTS
title_short Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
title_full Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
title_fullStr Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
title_full_unstemmed Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
title_sort Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.
dc.creator.none.fl_str_mv González, Exequiel Elías
Sesto Cabral, María Eugenia
author González, Exequiel Elías
author_facet González, Exequiel Elías
Sesto Cabral, María Eugenia
author_role author
author2 Sesto Cabral, María Eugenia
author2_role author
dc.subject.none.fl_str_mv BACTERIAL NANOCELLULOSE
MOSQUITO REPELENT
TOPICAL FORMULATION
NATURAL PRODUCTS
topic BACTERIAL NANOCELLULOSE
MOSQUITO REPELENT
TOPICAL FORMULATION
NATURAL PRODUCTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Bacterial Nano Cellulose (BNC) is a primary metabolite synthesized inside Pseudomonas fluorecens bacterial cell. BNC has distinctive characteristics that introduces modifications in its biological and physicochemical properties. Its swelling capacity under special conditions make it an unique model for semi-solid topical pharmaceutical forms design. Cleaner production studies developed in our laboratory demonstrate that it is possible to reduce the concentration of synthetic excipients in gel formulas with the addition of small concentrations of BNC. This work shows our experience in the redesign of the base formula for semi-solid gels, its implementation on the manufacture of a natural mosquito repelent, and a joint experience with a rural school and its comunity in Amberes-Tucuman-Argentina. The primary health care center (CAPS- Comuna de Amberes) provided alarming data regarding the prevalence of dengue virus, which is endemic in the area due to its geographical location. To the natural active pharmaceutical ingredient selection, aromatic plants from the area that contain citronellol and/or limonene in high concentrations were surveyed. Cymbopogon citratus, was selected, due to its abundance in the Amberes área. Safety evaluation and persitence studies of the repellent action were carried out on 100 healthy volunteers from Amberes commune.
Fil: González, Exequiel Elías. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
Fil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina
description Bacterial Nano Cellulose (BNC) is a primary metabolite synthesized inside Pseudomonas fluorecens bacterial cell. BNC has distinctive characteristics that introduces modifications in its biological and physicochemical properties. Its swelling capacity under special conditions make it an unique model for semi-solid topical pharmaceutical forms design. Cleaner production studies developed in our laboratory demonstrate that it is possible to reduce the concentration of synthetic excipients in gel formulas with the addition of small concentrations of BNC. This work shows our experience in the redesign of the base formula for semi-solid gels, its implementation on the manufacture of a natural mosquito repelent, and a joint experience with a rural school and its comunity in Amberes-Tucuman-Argentina. The primary health care center (CAPS- Comuna de Amberes) provided alarming data regarding the prevalence of dengue virus, which is endemic in the area due to its geographical location. To the natural active pharmaceutical ingredient selection, aromatic plants from the area that contain citronellol and/or limonene in high concentrations were surveyed. Cymbopogon citratus, was selected, due to its abundance in the Amberes área. Safety evaluation and persitence studies of the repellent action were carried out on 100 healthy volunteers from Amberes commune.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256863
González, Exequiel Elías; Sesto Cabral, María Eugenia; Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.; Salient Visionary Publication; International Clinical and Medical Case Reports Journal; 18; 12-2023; 1-15
2832-5788
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256863
identifier_str_mv González, Exequiel Elías; Sesto Cabral, María Eugenia; Bacterial Nanocellulose, A Natural Non-Active Pharmaceutical Ingredient for Gel Design. Finding a Natural Mosquito Repellent, A Community Experience.; Salient Visionary Publication; International Clinical and Medical Case Reports Journal; 18; 12-2023; 1-15
2832-5788
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://zenodo.org/records/10340001
info:eu-repo/semantics/altIdentifier/doi/10.5281/zenodo.10340000
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Salient Visionary Publication
publisher.none.fl_str_mv Salient Visionary Publication
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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