Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model

Autores
Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Thorp, S.I.; Curotto, P.; Medina, Vanina Araceli; Martinel Lamas, Diego José; Rivera, E.S.; Garabalino, M.A.; Farías, R.O.; Gonzalez, S.J.; Heber, E.M.; Itoiz, María Elina; Aromando, Romina Flavia; Nigg, D.W.; Trivillin, Verónica Andrea; Schwint, Amanda Elena
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor development from field-cancerized tissue in the hamster cheek pouch model. However, BNCT-induced mucositis in field-cancerized tissue was dose limiting. In a clinical scenario, oral mucositis affects patients' treatment and quality of life. Our aim was to evaluate different radioprotectors, seeking to reduce the incidence of BNCT-induced severe mucositis in field-cancerized tissue. Materials and Methods: Cancerized pouches treated with BNCT mediated by boronophenylalanine at 5 Gy were treated as follows: control: saline solution; Hishigh: histamine 5 mg kg-1; Hislow: histamine 1 mg kg-1; and JNJ7777120: 10 mg kg-1. Results: Hislow reduced the incidence of severe mucositis in field-cancerized tissue to 17% vs CONTROL: 55%; Hishigh: 67%; JNJ7777120: 57%. Hislow was non-toxic and did not compromise the long-term therapeutic effect of BNCT or alter gross boron concentration. Conclusion: Histamine reduces BNCT-induced mucositis in experimental oral precancer without jeopardizing therapeutic efficacy. The fact that both histamine and boronophenylalanine are approved for use in humans bridges the gap between experimental work and potential clinical application to reduce BNCT-induced radiotoxicity in patients with head and neck cancer.
Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
Fil: Thorp, S.I.. Comisión Nacional de Energía Atómica; Argentina
Fil: Curotto, P.. Comisión Nacional de Energía Atómica; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Martinel Lamas, Diego José. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Rivera, E.S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Garabalino, M.A.. Comisión Nacional de Energía Atómica; Argentina
Fil: Farías, R.O.. Comisión Nacional de Energía Atómica; Argentina
Fil: Gonzalez, S.J.. Comisión Nacional de Energía Atómica; Argentina
Fil: Heber, E.M.. Comisión Nacional de Energía Atómica; Argentina
Fil: Itoiz, María Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Nigg, D.W.. Idaho National Laboratory; Estados Unidos
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Materia
BNCT
BORON NEUTRON CAPTURE THERAPY
HAMSTER CHEEK POUCH PRECANCER MODEL
MUCOSITIS
ORAL CANCER
RADIOPROTECTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94812
Acceder
id CONICETDig_0c285c3c576fa22137a4eaab568f3630
oai_identifier_str oai:ri.conicet.gov.ar:11336/94812
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer modelMonti Hughes, AndreaPozzi, Emiliano César CayetanoThorp, S.I.Curotto, P.Medina, Vanina AraceliMartinel Lamas, Diego JoséRivera, E.S.Garabalino, M.A.Farías, R.O.Gonzalez, S.J.Heber, E.M.Itoiz, María ElinaAromando, Romina FlaviaNigg, D.W.Trivillin, Verónica AndreaSchwint, Amanda ElenaBNCTBORON NEUTRON CAPTURE THERAPYHAMSTER CHEEK POUCH PRECANCER MODELMUCOSITISORAL CANCERRADIOPROTECTORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor development from field-cancerized tissue in the hamster cheek pouch model. However, BNCT-induced mucositis in field-cancerized tissue was dose limiting. In a clinical scenario, oral mucositis affects patients' treatment and quality of life. Our aim was to evaluate different radioprotectors, seeking to reduce the incidence of BNCT-induced severe mucositis in field-cancerized tissue. Materials and Methods: Cancerized pouches treated with BNCT mediated by boronophenylalanine at 5 Gy were treated as follows: control: saline solution; Hishigh: histamine 5 mg kg-1; Hislow: histamine 1 mg kg-1; and JNJ7777120: 10 mg kg-1. Results: Hislow reduced the incidence of severe mucositis in field-cancerized tissue to 17% vs CONTROL: 55%; Hishigh: 67%; JNJ7777120: 57%. Hislow was non-toxic and did not compromise the long-term therapeutic effect of BNCT or alter gross boron concentration. Conclusion: Histamine reduces BNCT-induced mucositis in experimental oral precancer without jeopardizing therapeutic efficacy. The fact that both histamine and boronophenylalanine are approved for use in humans bridges the gap between experimental work and potential clinical application to reduce BNCT-induced radiotoxicity in patients with head and neck cancer.Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; ArgentinaFil: Thorp, S.I.. Comisión Nacional de Energía Atómica; ArgentinaFil: Curotto, P.. Comisión Nacional de Energía Atómica; ArgentinaFil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Martinel Lamas, Diego José. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Rivera, E.S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Garabalino, M.A.. Comisión Nacional de Energía Atómica; ArgentinaFil: Farías, R.O.. Comisión Nacional de Energía Atómica; ArgentinaFil: Gonzalez, S.J.. Comisión Nacional de Energía Atómica; ArgentinaFil: Heber, E.M.. Comisión Nacional de Energía Atómica; ArgentinaFil: Itoiz, María Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Nigg, D.W.. Idaho National Laboratory; Estados UnidosFil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaWiley Blackwell Publishing, Inc2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94812Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Thorp, S.I.; Curotto, P.; Medina, Vanina Araceli; et al.; Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model; Wiley Blackwell Publishing, Inc; Oral Diseases; 21; 6; 9-2015; 770-7771354-523XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.12346info:eu-repo/semantics/altIdentifier/doi/10.1111/odi.12346info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:10:28Zoai:ri.conicet.gov.ar:11336/94812instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:10:29.034CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
title Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
spellingShingle Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
Monti Hughes, Andrea
BNCT
BORON NEUTRON CAPTURE THERAPY
HAMSTER CHEEK POUCH PRECANCER MODEL
MUCOSITIS
ORAL CANCER
RADIOPROTECTOR
title_short Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
title_full Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
title_fullStr Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
title_full_unstemmed Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
title_sort Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
dc.creator.none.fl_str_mv Monti Hughes, Andrea
Pozzi, Emiliano César Cayetano
Thorp, S.I.
Curotto, P.
Medina, Vanina Araceli
Martinel Lamas, Diego José
Rivera, E.S.
Garabalino, M.A.
Farías, R.O.
Gonzalez, S.J.
Heber, E.M.
Itoiz, María Elina
Aromando, Romina Flavia
Nigg, D.W.
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author Monti Hughes, Andrea
author_facet Monti Hughes, Andrea
Pozzi, Emiliano César Cayetano
Thorp, S.I.
Curotto, P.
Medina, Vanina Araceli
Martinel Lamas, Diego José
Rivera, E.S.
Garabalino, M.A.
Farías, R.O.
Gonzalez, S.J.
Heber, E.M.
Itoiz, María Elina
Aromando, Romina Flavia
Nigg, D.W.
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author_role author
author2 Pozzi, Emiliano César Cayetano
Thorp, S.I.
Curotto, P.
Medina, Vanina Araceli
Martinel Lamas, Diego José
Rivera, E.S.
Garabalino, M.A.
Farías, R.O.
Gonzalez, S.J.
Heber, E.M.
Itoiz, María Elina
Aromando, Romina Flavia
Nigg, D.W.
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BNCT
BORON NEUTRON CAPTURE THERAPY
HAMSTER CHEEK POUCH PRECANCER MODEL
MUCOSITIS
ORAL CANCER
RADIOPROTECTOR
topic BNCT
BORON NEUTRON CAPTURE THERAPY
HAMSTER CHEEK POUCH PRECANCER MODEL
MUCOSITIS
ORAL CANCER
RADIOPROTECTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objectives: Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor development from field-cancerized tissue in the hamster cheek pouch model. However, BNCT-induced mucositis in field-cancerized tissue was dose limiting. In a clinical scenario, oral mucositis affects patients' treatment and quality of life. Our aim was to evaluate different radioprotectors, seeking to reduce the incidence of BNCT-induced severe mucositis in field-cancerized tissue. Materials and Methods: Cancerized pouches treated with BNCT mediated by boronophenylalanine at 5 Gy were treated as follows: control: saline solution; Hishigh: histamine 5 mg kg-1; Hislow: histamine 1 mg kg-1; and JNJ7777120: 10 mg kg-1. Results: Hislow reduced the incidence of severe mucositis in field-cancerized tissue to 17% vs CONTROL: 55%; Hishigh: 67%; JNJ7777120: 57%. Hislow was non-toxic and did not compromise the long-term therapeutic effect of BNCT or alter gross boron concentration. Conclusion: Histamine reduces BNCT-induced mucositis in experimental oral precancer without jeopardizing therapeutic efficacy. The fact that both histamine and boronophenylalanine are approved for use in humans bridges the gap between experimental work and potential clinical application to reduce BNCT-induced radiotoxicity in patients with head and neck cancer.
Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
Fil: Thorp, S.I.. Comisión Nacional de Energía Atómica; Argentina
Fil: Curotto, P.. Comisión Nacional de Energía Atómica; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Martinel Lamas, Diego José. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Rivera, E.S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Garabalino, M.A.. Comisión Nacional de Energía Atómica; Argentina
Fil: Farías, R.O.. Comisión Nacional de Energía Atómica; Argentina
Fil: Gonzalez, S.J.. Comisión Nacional de Energía Atómica; Argentina
Fil: Heber, E.M.. Comisión Nacional de Energía Atómica; Argentina
Fil: Itoiz, María Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Nigg, D.W.. Idaho National Laboratory; Estados Unidos
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
description Objectives: Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor development from field-cancerized tissue in the hamster cheek pouch model. However, BNCT-induced mucositis in field-cancerized tissue was dose limiting. In a clinical scenario, oral mucositis affects patients' treatment and quality of life. Our aim was to evaluate different radioprotectors, seeking to reduce the incidence of BNCT-induced severe mucositis in field-cancerized tissue. Materials and Methods: Cancerized pouches treated with BNCT mediated by boronophenylalanine at 5 Gy were treated as follows: control: saline solution; Hishigh: histamine 5 mg kg-1; Hislow: histamine 1 mg kg-1; and JNJ7777120: 10 mg kg-1. Results: Hislow reduced the incidence of severe mucositis in field-cancerized tissue to 17% vs CONTROL: 55%; Hishigh: 67%; JNJ7777120: 57%. Hislow was non-toxic and did not compromise the long-term therapeutic effect of BNCT or alter gross boron concentration. Conclusion: Histamine reduces BNCT-induced mucositis in experimental oral precancer without jeopardizing therapeutic efficacy. The fact that both histamine and boronophenylalanine are approved for use in humans bridges the gap between experimental work and potential clinical application to reduce BNCT-induced radiotoxicity in patients with head and neck cancer.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94812
Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Thorp, S.I.; Curotto, P.; Medina, Vanina Araceli; et al.; Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model; Wiley Blackwell Publishing, Inc; Oral Diseases; 21; 6; 9-2015; 770-777
1354-523X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94812
identifier_str_mv Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Thorp, S.I.; Curotto, P.; Medina, Vanina Araceli; et al.; Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model; Wiley Blackwell Publishing, Inc; Oral Diseases; 21; 6; 9-2015; 770-777
1354-523X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1111/odi.12346
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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