β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2

Autores
Sterin Borda, Leonor; Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this paper, we demonstrate that circulating antibodies from chronic periodontitis patients reacting with atrial β1-adrenoceptors (β1-ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E2 (PGE2) generation. By enzyme-linked immunosorbent assay using β1 synthetic peptide (with an amino acid sequence identical to the second loop of human myocardial β1-ARs) as a coating antigen, we demonstrated reactivity against the second extracellular loop on human myocardial β1-ARs. This autoantibody present in the serum of chronic periodontitis patients was significantly correlated with the release of sCD40L and PGE2. The release of sCD40L was blunted by atenolol, SP600125 and β1 synthetic peptide, and PGE2 generation was inhibited by DuP 697 and slightly by FR122049. The effects of the antibody incubated with isolated rat atria upregulated sCD40L release with an increase of PGE2 production and c-Jun N-terminal kinase phosphorylation. These results indicate that in chronic periodontitis patients, there is a positive association between sCD40L release and PGE2 generation via the action of β1-AR antibodies.
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Borda, Enri Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Materia
CD 40 LINGAND
PROSTAGLANDIN
ADRENORECEPTOR ANTIBODY
JNK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216459

id CONICETDig_0c2803da9d221d7060a5554dfd7fe78c
oai_identifier_str oai:ri.conicet.gov.ar:11336/216459
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2Sterin Borda, LeonorSegovia, MarcelaReina, Silvia LorenaBorda, Enri SantiagoCD 40 LINGANDPROSTAGLANDINADRENORECEPTOR ANTIBODYJNKhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3In this paper, we demonstrate that circulating antibodies from chronic periodontitis patients reacting with atrial β1-adrenoceptors (β1-ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E2 (PGE2) generation. By enzyme-linked immunosorbent assay using β1 synthetic peptide (with an amino acid sequence identical to the second loop of human myocardial β1-ARs) as a coating antigen, we demonstrated reactivity against the second extracellular loop on human myocardial β1-ARs. This autoantibody present in the serum of chronic periodontitis patients was significantly correlated with the release of sCD40L and PGE2. The release of sCD40L was blunted by atenolol, SP600125 and β1 synthetic peptide, and PGE2 generation was inhibited by DuP 697 and slightly by FR122049. The effects of the antibody incubated with isolated rat atria upregulated sCD40L release with an increase of PGE2 production and c-Jun N-terminal kinase phosphorylation. These results indicate that in chronic periodontitis patients, there is a positive association between sCD40L release and PGE2 generation via the action of β1-AR antibodies.Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Borda, Enri Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaWiley Blackwell Publishing, Inc2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216459Sterin Borda, Leonor; Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2; Wiley Blackwell Publishing, Inc; Experimental Physiology; 97; 9; 4-2012; 1030-10390958-0670CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2012.065748info:eu-repo/semantics/altIdentifier/doi/10.1113/expphysiol.2012.065748info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:28Zoai:ri.conicet.gov.ar:11336/216459instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:28.636CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
title β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
spellingShingle β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
Sterin Borda, Leonor
CD 40 LINGAND
PROSTAGLANDIN
ADRENORECEPTOR ANTIBODY
JNK
title_short β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
title_full β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
title_fullStr β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
title_full_unstemmed β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
title_sort β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2
dc.creator.none.fl_str_mv Sterin Borda, Leonor
Segovia, Marcela
Reina, Silvia Lorena
Borda, Enri Santiago
author Sterin Borda, Leonor
author_facet Sterin Borda, Leonor
Segovia, Marcela
Reina, Silvia Lorena
Borda, Enri Santiago
author_role author
author2 Segovia, Marcela
Reina, Silvia Lorena
Borda, Enri Santiago
author2_role author
author
author
dc.subject.none.fl_str_mv CD 40 LINGAND
PROSTAGLANDIN
ADRENORECEPTOR ANTIBODY
JNK
topic CD 40 LINGAND
PROSTAGLANDIN
ADRENORECEPTOR ANTIBODY
JNK
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this paper, we demonstrate that circulating antibodies from chronic periodontitis patients reacting with atrial β1-adrenoceptors (β1-ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E2 (PGE2) generation. By enzyme-linked immunosorbent assay using β1 synthetic peptide (with an amino acid sequence identical to the second loop of human myocardial β1-ARs) as a coating antigen, we demonstrated reactivity against the second extracellular loop on human myocardial β1-ARs. This autoantibody present in the serum of chronic periodontitis patients was significantly correlated with the release of sCD40L and PGE2. The release of sCD40L was blunted by atenolol, SP600125 and β1 synthetic peptide, and PGE2 generation was inhibited by DuP 697 and slightly by FR122049. The effects of the antibody incubated with isolated rat atria upregulated sCD40L release with an increase of PGE2 production and c-Jun N-terminal kinase phosphorylation. These results indicate that in chronic periodontitis patients, there is a positive association between sCD40L release and PGE2 generation via the action of β1-AR antibodies.
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Borda, Enri Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
description In this paper, we demonstrate that circulating antibodies from chronic periodontitis patients reacting with atrial β1-adrenoceptors (β1-ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E2 (PGE2) generation. By enzyme-linked immunosorbent assay using β1 synthetic peptide (with an amino acid sequence identical to the second loop of human myocardial β1-ARs) as a coating antigen, we demonstrated reactivity against the second extracellular loop on human myocardial β1-ARs. This autoantibody present in the serum of chronic periodontitis patients was significantly correlated with the release of sCD40L and PGE2. The release of sCD40L was blunted by atenolol, SP600125 and β1 synthetic peptide, and PGE2 generation was inhibited by DuP 697 and slightly by FR122049. The effects of the antibody incubated with isolated rat atria upregulated sCD40L release with an increase of PGE2 production and c-Jun N-terminal kinase phosphorylation. These results indicate that in chronic periodontitis patients, there is a positive association between sCD40L release and PGE2 generation via the action of β1-AR antibodies.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216459
Sterin Borda, Leonor; Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2; Wiley Blackwell Publishing, Inc; Experimental Physiology; 97; 9; 4-2012; 1030-1039
0958-0670
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216459
identifier_str_mv Sterin Borda, Leonor; Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: Role of prostaglandin E2; Wiley Blackwell Publishing, Inc; Experimental Physiology; 97; 9; 4-2012; 1030-1039
0958-0670
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2012.065748
info:eu-repo/semantics/altIdentifier/doi/10.1113/expphysiol.2012.065748
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844612990185242624
score 13.070432