Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51

Autores
Galigniana, Natalia Maricel; Ballmer, Luzia Thea; Toneatto, Judith; Erlejman, Alejandra Giselle; Lagadari, Mariana; Galigniana, Mario Daniel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response.
Fil: Galigniana, Natalia Maricel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Ballmer, Luzia Thea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Erlejman, Alejandra Giselle. Universidad de Buenos Aires; Argentina
Fil: Lagadari, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
DEPRESSION
GLUCOCORTICOID RECEPTOR
HSP90
HYPOTHALAMIC- PITUITARY-ADRENAL AXIS
IMMUNOPHILIN
TETRATRICOPEPTIDE REPEAT DOMAIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84571
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/84571
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51Galigniana, Natalia MaricelBallmer, Luzia TheaToneatto, JudithErlejman, Alejandra GiselleLagadari, MarianaGaligniana, Mario DanielDEPRESSIONGLUCOCORTICOID RECEPTORHSP90HYPOTHALAMIC- PITUITARY-ADRENAL AXISIMMUNOPHILINTETRATRICOPEPTIDE REPEAT DOMAINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response.Fil: Galigniana, Natalia Maricel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ballmer, Luzia Thea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Erlejman, Alejandra Giselle. Universidad de Buenos Aires; ArgentinaFil: Lagadari, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaWiley Blackwell Publishing, Inc2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84571Galigniana, Natalia Maricel; Ballmer, Luzia Thea; Toneatto, Judith; Erlejman, Alejandra Giselle; Lagadari, Mariana; et al.; Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 122; 1; 7-2012; 4-180022-3042CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2012.07775.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2012.07775.xinfo:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/22548329info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:40Zoai:ri.conicet.gov.ar:11336/84571instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:41.223CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
title Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
spellingShingle Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
Galigniana, Natalia Maricel
DEPRESSION
GLUCOCORTICOID RECEPTOR
HSP90
HYPOTHALAMIC- PITUITARY-ADRENAL AXIS
IMMUNOPHILIN
TETRATRICOPEPTIDE REPEAT DOMAIN
title_short Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
title_full Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
title_fullStr Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
title_full_unstemmed Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
title_sort Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
dc.creator.none.fl_str_mv Galigniana, Natalia Maricel
Ballmer, Luzia Thea
Toneatto, Judith
Erlejman, Alejandra Giselle
Lagadari, Mariana
Galigniana, Mario Daniel
author Galigniana, Natalia Maricel
author_facet Galigniana, Natalia Maricel
Ballmer, Luzia Thea
Toneatto, Judith
Erlejman, Alejandra Giselle
Lagadari, Mariana
Galigniana, Mario Daniel
author_role author
author2 Ballmer, Luzia Thea
Toneatto, Judith
Erlejman, Alejandra Giselle
Lagadari, Mariana
Galigniana, Mario Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv DEPRESSION
GLUCOCORTICOID RECEPTOR
HSP90
HYPOTHALAMIC- PITUITARY-ADRENAL AXIS
IMMUNOPHILIN
TETRATRICOPEPTIDE REPEAT DOMAIN
topic DEPRESSION
GLUCOCORTICOID RECEPTOR
HSP90
HYPOTHALAMIC- PITUITARY-ADRENAL AXIS
IMMUNOPHILIN
TETRATRICOPEPTIDE REPEAT DOMAIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response.
Fil: Galigniana, Natalia Maricel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Ballmer, Luzia Thea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Erlejman, Alejandra Giselle. Universidad de Buenos Aires; Argentina
Fil: Lagadari, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84571
Galigniana, Natalia Maricel; Ballmer, Luzia Thea; Toneatto, Judith; Erlejman, Alejandra Giselle; Lagadari, Mariana; et al.; Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 122; 1; 7-2012; 4-18
0022-3042
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84571
identifier_str_mv Galigniana, Natalia Maricel; Ballmer, Luzia Thea; Toneatto, Judith; Erlejman, Alejandra Giselle; Lagadari, Mariana; et al.; Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 122; 1; 7-2012; 4-18
0022-3042
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2012.07775.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2012.07775.x
info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/22548329
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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