Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation

Autores
Liaudat, Ana Cecilia; Rodríguez, N.; Chen, S.; Romanini, María Cristina; Vivas, A.; Rolando, A.; Gauna, H.; Mayer, N.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Stress in pregnant rats caused by chronic immobilization alters the pattern of secretion of corticosterone and modifies the hypothalamic-pituitary-adrenal axis (HPA) of the fetus. Early postnatal handling, however, may reverse the effects of increased secretion of corticosterone. We investigated the effects of prenatal stress and postnatal handling on the activity of the HPA axis of male offspring of stressed female rats. Male 90-day-old rats from four groups were investigated: prenatally stressed animals without postnatal handling, prenatally stressed animals with postnatal handling, unstressed control animals with postnatal handling, and unstressed control animals without postnatal handling. After sacrifice, the adrenal glands were weighed to determine the adrenal-somatic index. Apoptosis was evaluated by TUNEL assay and active caspase-3 expression. We found that the adrenal gland cortex:medulla ratio increased in animals with prenatal stress and that eventually the stress caused apoptosis. Handling newborns to simulate maternal activity ameliorated some of the negative effects of prenatal stress.
Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Chen, S.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Romanini, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vivas, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Rolando, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Gauna, H.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Mayer, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Materia
Adrenal Gland
Apoptosis
Handling
Hypothalamic-Pituitary-Adrenal Axis
Immobilization
Prenatal Stress
Rats
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39704
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/39704
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Adrenal response of male rats exposed to prenatal stress and early postnatal stimulationLiaudat, Ana CeciliaRodríguez, N.Chen, S.Romanini, María CristinaVivas, A.Rolando, A.Gauna, H.Mayer, N.Adrenal GlandApoptosisHandlingHypothalamic-Pituitary-Adrenal AxisImmobilizationPrenatal StressRatshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Stress in pregnant rats caused by chronic immobilization alters the pattern of secretion of corticosterone and modifies the hypothalamic-pituitary-adrenal axis (HPA) of the fetus. Early postnatal handling, however, may reverse the effects of increased secretion of corticosterone. We investigated the effects of prenatal stress and postnatal handling on the activity of the HPA axis of male offspring of stressed female rats. Male 90-day-old rats from four groups were investigated: prenatally stressed animals without postnatal handling, prenatally stressed animals with postnatal handling, unstressed control animals with postnatal handling, and unstressed control animals without postnatal handling. After sacrifice, the adrenal glands were weighed to determine the adrenal-somatic index. Apoptosis was evaluated by TUNEL assay and active caspase-3 expression. We found that the adrenal gland cortex:medulla ratio increased in animals with prenatal stress and that eventually the stress caused apoptosis. Handling newborns to simulate maternal activity ameliorated some of the negative effects of prenatal stress.Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodríguez, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Chen, S.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Romanini, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vivas, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Rolando, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Gauna, H.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Mayer, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaInforma Healthcare2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39704Liaudat, Ana Cecilia; Rodríguez, N.; Chen, S.; Romanini, María Cristina; Vivas, A.; et al.; Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation; Informa Healthcare; Biotechnic and Histochemistry; 90; 6; 8-2015; 432-4381052-0295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/10520295.2015.1019926info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/10520295.2015.1019926info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:41:49Zoai:ri.conicet.gov.ar:11336/39704instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:41:50.163CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
title Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
spellingShingle Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
Liaudat, Ana Cecilia
Adrenal Gland
Apoptosis
Handling
Hypothalamic-Pituitary-Adrenal Axis
Immobilization
Prenatal Stress
Rats
title_short Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
title_full Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
title_fullStr Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
title_full_unstemmed Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
title_sort Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
dc.creator.none.fl_str_mv Liaudat, Ana Cecilia
Rodríguez, N.
Chen, S.
Romanini, María Cristina
Vivas, A.
Rolando, A.
Gauna, H.
Mayer, N.
author Liaudat, Ana Cecilia
author_facet Liaudat, Ana Cecilia
Rodríguez, N.
Chen, S.
Romanini, María Cristina
Vivas, A.
Rolando, A.
Gauna, H.
Mayer, N.
author_role author
author2 Rodríguez, N.
Chen, S.
Romanini, María Cristina
Vivas, A.
Rolando, A.
Gauna, H.
Mayer, N.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adrenal Gland
Apoptosis
Handling
Hypothalamic-Pituitary-Adrenal Axis
Immobilization
Prenatal Stress
Rats
topic Adrenal Gland
Apoptosis
Handling
Hypothalamic-Pituitary-Adrenal Axis
Immobilization
Prenatal Stress
Rats
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Stress in pregnant rats caused by chronic immobilization alters the pattern of secretion of corticosterone and modifies the hypothalamic-pituitary-adrenal axis (HPA) of the fetus. Early postnatal handling, however, may reverse the effects of increased secretion of corticosterone. We investigated the effects of prenatal stress and postnatal handling on the activity of the HPA axis of male offspring of stressed female rats. Male 90-day-old rats from four groups were investigated: prenatally stressed animals without postnatal handling, prenatally stressed animals with postnatal handling, unstressed control animals with postnatal handling, and unstressed control animals without postnatal handling. After sacrifice, the adrenal glands were weighed to determine the adrenal-somatic index. Apoptosis was evaluated by TUNEL assay and active caspase-3 expression. We found that the adrenal gland cortex:medulla ratio increased in animals with prenatal stress and that eventually the stress caused apoptosis. Handling newborns to simulate maternal activity ameliorated some of the negative effects of prenatal stress.
Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Chen, S.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Romanini, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vivas, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Rolando, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Gauna, H.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Mayer, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
description Stress in pregnant rats caused by chronic immobilization alters the pattern of secretion of corticosterone and modifies the hypothalamic-pituitary-adrenal axis (HPA) of the fetus. Early postnatal handling, however, may reverse the effects of increased secretion of corticosterone. We investigated the effects of prenatal stress and postnatal handling on the activity of the HPA axis of male offspring of stressed female rats. Male 90-day-old rats from four groups were investigated: prenatally stressed animals without postnatal handling, prenatally stressed animals with postnatal handling, unstressed control animals with postnatal handling, and unstressed control animals without postnatal handling. After sacrifice, the adrenal glands were weighed to determine the adrenal-somatic index. Apoptosis was evaluated by TUNEL assay and active caspase-3 expression. We found that the adrenal gland cortex:medulla ratio increased in animals with prenatal stress and that eventually the stress caused apoptosis. Handling newborns to simulate maternal activity ameliorated some of the negative effects of prenatal stress.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39704
Liaudat, Ana Cecilia; Rodríguez, N.; Chen, S.; Romanini, María Cristina; Vivas, A.; et al.; Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation; Informa Healthcare; Biotechnic and Histochemistry; 90; 6; 8-2015; 432-438
1052-0295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39704
identifier_str_mv Liaudat, Ana Cecilia; Rodríguez, N.; Chen, S.; Romanini, María Cristina; Vivas, A.; et al.; Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation; Informa Healthcare; Biotechnic and Histochemistry; 90; 6; 8-2015; 432-438
1052-0295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/10520295.2015.1019926
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/10520295.2015.1019926
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.221938

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