Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens

Autores
Valdez, Diego Javier; Nieto, Paula Sofia; Della Costa, Natalia Soledad; Schurrer, Clemar; Guido, Mario Eduardo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
PURPOSE. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions. METHODS. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions. RESULTS. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day. CONCLUSIONS. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of lig
Fil: Valdez, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
Fil: Nieto, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
Fil: Della Costa, Natalia Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Schurrer, Clemar. Universidad Tecnologica Nacional. Facultad Regional Cordoba; Argentina
Fil: Guido, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
Materia
PUPILLARI LIGHT REFLEXES
MELANOPSIN
BLINDNESS
CIRCADIAN RHYTHM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11570
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/11570
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* ChickensValdez, Diego JavierNieto, Paula SofiaDella Costa, Natalia SoledadSchurrer, ClemarGuido, Mario EduardoPUPILLARI LIGHT REFLEXESMELANOPSINBLINDNESSCIRCADIAN RHYTHMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1PURPOSE. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions. METHODS. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions. RESULTS. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day. CONCLUSIONS. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of ligFil: Valdez, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); ArgentinaFil: Nieto, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); ArgentinaFil: Della Costa, Natalia Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Schurrer, Clemar. Universidad Tecnologica Nacional. Facultad Regional Cordoba; ArgentinaFil: Guido, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); ArgentinaAssociation For Research In Vision And Ophthalmology2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11570Valdez, Diego Javier; Nieto, Paula Sofia; Della Costa, Natalia Soledad; Schurrer, Clemar; Guido, Mario Eduardo; Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 56; 2; 1-2015; 730-7370146-0404enginfo:eu-repo/semantics/altIdentifier/url/http://iovs.arvojournals.org/article.aspx?articleid=2212827info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.14-15481info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:35Zoai:ri.conicet.gov.ar:11336/11570instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:36.213CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
title Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
spellingShingle Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
Valdez, Diego Javier
PUPILLARI LIGHT REFLEXES
MELANOPSIN
BLINDNESS
CIRCADIAN RHYTHM
title_short Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
title_full Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
title_fullStr Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
title_full_unstemmed Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
title_sort Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
dc.creator.none.fl_str_mv Valdez, Diego Javier
Nieto, Paula Sofia
Della Costa, Natalia Soledad
Schurrer, Clemar
Guido, Mario Eduardo
author Valdez, Diego Javier
author_facet Valdez, Diego Javier
Nieto, Paula Sofia
Della Costa, Natalia Soledad
Schurrer, Clemar
Guido, Mario Eduardo
author_role author
author2 Nieto, Paula Sofia
Della Costa, Natalia Soledad
Schurrer, Clemar
Guido, Mario Eduardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv PUPILLARI LIGHT REFLEXES
MELANOPSIN
BLINDNESS
CIRCADIAN RHYTHM
topic PUPILLARI LIGHT REFLEXES
MELANOPSIN
BLINDNESS
CIRCADIAN RHYTHM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv PURPOSE. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions. METHODS. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions. RESULTS. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day. CONCLUSIONS. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of lig
Fil: Valdez, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
Fil: Nieto, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
Fil: Della Costa, Natalia Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Schurrer, Clemar. Universidad Tecnologica Nacional. Facultad Regional Cordoba; Argentina
Fil: Guido, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
description PURPOSE. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions. METHODS. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions. RESULTS. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day. CONCLUSIONS. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of lig
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11570
Valdez, Diego Javier; Nieto, Paula Sofia; Della Costa, Natalia Soledad; Schurrer, Clemar; Guido, Mario Eduardo; Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 56; 2; 1-2015; 730-737
0146-0404
url http://hdl.handle.net/11336/11570
identifier_str_mv Valdez, Diego Javier; Nieto, Paula Sofia; Della Costa, Natalia Soledad; Schurrer, Clemar; Guido, Mario Eduardo; Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 56; 2; 1-2015; 730-737
0146-0404
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://iovs.arvojournals.org/article.aspx?articleid=2212827
info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.14-15481
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Association For Research In Vision And Ophthalmology
publisher.none.fl_str_mv Association For Research In Vision And Ophthalmology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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