Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
- Autores
- Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; Bortoluzzi, Adailton João; Cuffini, Silvia Lucia; Cardoso, Simone Goncalves
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.
Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil
Fil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; Brasil
Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil
Fil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Bortoluzzi, Adailton João. Universidade Federal de Santa Catarina; Brasil
Fil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal de Santa Catarina; Brasil
Fil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; Brasil - Materia
-
Terbinafine Hydrochloride
Single Crystal Structure
Solid State Characterization
Intrinsic Disolution Rate - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/25784
Ver los metadatos del registro completo
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Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochlorideKuminek, GislaineRauber, Gabriela SchneiderRiekes, Manoela KlüppelCampos, Carlos Eduardo Maduro deMonti, Gustavo AlbertoBortoluzzi, Adailton JoãoCuffini, Silvia LuciaCardoso, Simone GoncalvesTerbinafine HydrochlorideSingle Crystal StructureSolid State CharacterizationIntrinsic Disolution Ratehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; BrasilFil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; BrasilFil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; BrasilFil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Bortoluzzi, Adailton João. Universidade Federal de Santa Catarina; BrasilFil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal de Santa Catarina; BrasilFil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; BrasilElsevier Science2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25784Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-1110731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.02.001info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513000587info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:05Zoai:ri.conicet.gov.ar:11336/25784instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:05.498CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
title |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
spellingShingle |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride Kuminek, Gislaine Terbinafine Hydrochloride Single Crystal Structure Solid State Characterization Intrinsic Disolution Rate |
title_short |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
title_full |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
title_fullStr |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
title_full_unstemmed |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
title_sort |
Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride |
dc.creator.none.fl_str_mv |
Kuminek, Gislaine Rauber, Gabriela Schneider Riekes, Manoela Klüppel Campos, Carlos Eduardo Maduro de Monti, Gustavo Alberto Bortoluzzi, Adailton João Cuffini, Silvia Lucia Cardoso, Simone Goncalves |
author |
Kuminek, Gislaine |
author_facet |
Kuminek, Gislaine Rauber, Gabriela Schneider Riekes, Manoela Klüppel Campos, Carlos Eduardo Maduro de Monti, Gustavo Alberto Bortoluzzi, Adailton João Cuffini, Silvia Lucia Cardoso, Simone Goncalves |
author_role |
author |
author2 |
Rauber, Gabriela Schneider Riekes, Manoela Klüppel Campos, Carlos Eduardo Maduro de Monti, Gustavo Alberto Bortoluzzi, Adailton João Cuffini, Silvia Lucia Cardoso, Simone Goncalves |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Terbinafine Hydrochloride Single Crystal Structure Solid State Characterization Intrinsic Disolution Rate |
topic |
Terbinafine Hydrochloride Single Crystal Structure Solid State Characterization Intrinsic Disolution Rate |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks. Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil Fil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; Brasil Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil Fil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; Brasil Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina Fil: Bortoluzzi, Adailton João. Universidade Federal de Santa Catarina; Brasil Fil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal de Santa Catarina; Brasil Fil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; Brasil |
description |
Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/25784 Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-111 0731-7085 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/25784 |
identifier_str_mv |
Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-111 0731-7085 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.02.001 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513000587 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614102174924800 |
score |
13.070432 |