Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride

Autores
Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; Bortoluzzi, Adailton João; Cuffini, Silvia Lucia; Cardoso, Simone Goncalves
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.
Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil
Fil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; Brasil
Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil
Fil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Bortoluzzi, Adailton João. Universidade Federal de Santa Catarina; Brasil
Fil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal de Santa Catarina; Brasil
Fil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; Brasil
Materia
Terbinafine Hydrochloride
Single Crystal Structure
Solid State Characterization
Intrinsic Disolution Rate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25784

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochlorideKuminek, GislaineRauber, Gabriela SchneiderRiekes, Manoela KlüppelCampos, Carlos Eduardo Maduro deMonti, Gustavo AlbertoBortoluzzi, Adailton JoãoCuffini, Silvia LuciaCardoso, Simone GoncalvesTerbinafine HydrochlorideSingle Crystal StructureSolid State CharacterizationIntrinsic Disolution Ratehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; BrasilFil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; BrasilFil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; BrasilFil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Bortoluzzi, Adailton João. Universidade Federal de Santa Catarina; BrasilFil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal de Santa Catarina; BrasilFil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; BrasilElsevier Science2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25784Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-1110731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.02.001info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513000587info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:05Zoai:ri.conicet.gov.ar:11336/25784instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:05.498CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
title Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
spellingShingle Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
Kuminek, Gislaine
Terbinafine Hydrochloride
Single Crystal Structure
Solid State Characterization
Intrinsic Disolution Rate
title_short Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
title_full Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
title_fullStr Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
title_full_unstemmed Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
title_sort Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
dc.creator.none.fl_str_mv Kuminek, Gislaine
Rauber, Gabriela Schneider
Riekes, Manoela Klüppel
Campos, Carlos Eduardo Maduro de
Monti, Gustavo Alberto
Bortoluzzi, Adailton João
Cuffini, Silvia Lucia
Cardoso, Simone Goncalves
author Kuminek, Gislaine
author_facet Kuminek, Gislaine
Rauber, Gabriela Schneider
Riekes, Manoela Klüppel
Campos, Carlos Eduardo Maduro de
Monti, Gustavo Alberto
Bortoluzzi, Adailton João
Cuffini, Silvia Lucia
Cardoso, Simone Goncalves
author_role author
author2 Rauber, Gabriela Schneider
Riekes, Manoela Klüppel
Campos, Carlos Eduardo Maduro de
Monti, Gustavo Alberto
Bortoluzzi, Adailton João
Cuffini, Silvia Lucia
Cardoso, Simone Goncalves
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Terbinafine Hydrochloride
Single Crystal Structure
Solid State Characterization
Intrinsic Disolution Rate
topic Terbinafine Hydrochloride
Single Crystal Structure
Solid State Characterization
Intrinsic Disolution Rate
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.
Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil
Fil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; Brasil
Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil
Fil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Bortoluzzi, Adailton João. Universidade Federal de Santa Catarina; Brasil
Fil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal de Santa Catarina; Brasil
Fil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; Brasil
description Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25784
Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-111
0731-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25784
identifier_str_mv Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-111
0731-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.02.001
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513000587
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432