Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
- Autores
- Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; Monti, Gustavo Alberto; Cuffini, Silvia L.; Cardoso, Simone
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate.
Fil: Borgmann, Silvia H. M.. Universidade Federal de Santa Catarina; Brasil
Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil
Fil: Rauber, Gabriela S.. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo R.. Universidade Federal de Santa Catarina; Brasil
Fil: Campos, Carlos E.M. de. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuffini, Silvia L.. Universidade Federal de Santa Catarina; Brasil
Fil: Cardoso, Simone. Universidade Federal de Santa Catarina; Brasil - Materia
-
Solid State
Intrinsic Disolution Rate
Fluvastatine Sodium Hydrates - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/25517
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Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydratesBorgmann, Silvia H. M.Bernardi, Larissa S.Rauber, Gabriela S.Oliveira, Paulo R.Campos, Carlos E.M. deMonti, Gustavo AlbertoCuffini, Silvia L.Cardoso, SimoneSolid StateIntrinsic Disolution RateFluvastatine Sodium Hydrateshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate.Fil: Borgmann, Silvia H. M.. Universidade Federal de Santa Catarina; BrasilFil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; BrasilFil: Rauber, Gabriela S.. Universidade Federal de Santa Catarina; BrasilFil: Oliveira, Paulo R.. Universidade Federal de Santa Catarina; BrasilFil: Campos, Carlos E.M. de. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuffini, Silvia L.. Universidade Federal de Santa Catarina; BrasilFil: Cardoso, Simone. Universidade Federal de Santa Catarina; BrasilTaylor & Francis2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25517Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; et al.; Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates; Taylor & Francis; Pharmaceutical Development and Technology; 18; 2; 10-2012; 525-5341083-7450CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/10837450.2012.727000info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727000info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:22Zoai:ri.conicet.gov.ar:11336/25517instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:22.938CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
title |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
spellingShingle |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates Borgmann, Silvia H. M. Solid State Intrinsic Disolution Rate Fluvastatine Sodium Hydrates |
title_short |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
title_full |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
title_fullStr |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
title_full_unstemmed |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
title_sort |
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates |
dc.creator.none.fl_str_mv |
Borgmann, Silvia H. M. Bernardi, Larissa S. Rauber, Gabriela S. Oliveira, Paulo R. Campos, Carlos E.M. de Monti, Gustavo Alberto Cuffini, Silvia L. Cardoso, Simone |
author |
Borgmann, Silvia H. M. |
author_facet |
Borgmann, Silvia H. M. Bernardi, Larissa S. Rauber, Gabriela S. Oliveira, Paulo R. Campos, Carlos E.M. de Monti, Gustavo Alberto Cuffini, Silvia L. Cardoso, Simone |
author_role |
author |
author2 |
Bernardi, Larissa S. Rauber, Gabriela S. Oliveira, Paulo R. Campos, Carlos E.M. de Monti, Gustavo Alberto Cuffini, Silvia L. Cardoso, Simone |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Solid State Intrinsic Disolution Rate Fluvastatine Sodium Hydrates |
topic |
Solid State Intrinsic Disolution Rate Fluvastatine Sodium Hydrates |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate. Fil: Borgmann, Silvia H. M.. Universidade Federal de Santa Catarina; Brasil Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil Fil: Rauber, Gabriela S.. Universidade Federal de Santa Catarina; Brasil Fil: Oliveira, Paulo R.. Universidade Federal de Santa Catarina; Brasil Fil: Campos, Carlos E.M. de. Universidade Federal de Santa Catarina; Brasil Fil: Monti, Gustavo Alberto. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cuffini, Silvia L.. Universidade Federal de Santa Catarina; Brasil Fil: Cardoso, Simone. Universidade Federal de Santa Catarina; Brasil |
description |
The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/25517 Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; et al.; Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates; Taylor & Francis; Pharmaceutical Development and Technology; 18; 2; 10-2012; 525-534 1083-7450 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/25517 |
identifier_str_mv |
Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; et al.; Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates; Taylor & Francis; Pharmaceutical Development and Technology; 18; 2; 10-2012; 525-534 1083-7450 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3109/10837450.2012.727000 info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727000 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614050053357568 |
score |
13.070432 |