Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates

Autores
Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; Monti, Gustavo Alberto; Cuffini, Silvia L.; Cardoso, Simone
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate.
Fil: Borgmann, Silvia H. M.. Universidade Federal de Santa Catarina; Brasil
Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil
Fil: Rauber, Gabriela S.. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo R.. Universidade Federal de Santa Catarina; Brasil
Fil: Campos, Carlos E.M. de. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuffini, Silvia L.. Universidade Federal de Santa Catarina; Brasil
Fil: Cardoso, Simone. Universidade Federal de Santa Catarina; Brasil
Materia
Solid State
Intrinsic Disolution Rate
Fluvastatine Sodium Hydrates
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25517

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network_name_str CONICET Digital (CONICET)
spelling Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydratesBorgmann, Silvia H. M.Bernardi, Larissa S.Rauber, Gabriela S.Oliveira, Paulo R.Campos, Carlos E.M. deMonti, Gustavo AlbertoCuffini, Silvia L.Cardoso, SimoneSolid StateIntrinsic Disolution RateFluvastatine Sodium Hydrateshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate.Fil: Borgmann, Silvia H. M.. Universidade Federal de Santa Catarina; BrasilFil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; BrasilFil: Rauber, Gabriela S.. Universidade Federal de Santa Catarina; BrasilFil: Oliveira, Paulo R.. Universidade Federal de Santa Catarina; BrasilFil: Campos, Carlos E.M. de. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuffini, Silvia L.. Universidade Federal de Santa Catarina; BrasilFil: Cardoso, Simone. Universidade Federal de Santa Catarina; BrasilTaylor & Francis2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25517Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; et al.; Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates; Taylor & Francis; Pharmaceutical Development and Technology; 18; 2; 10-2012; 525-5341083-7450CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/10837450.2012.727000info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727000info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:22Zoai:ri.conicet.gov.ar:11336/25517instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:22.938CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
title Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
spellingShingle Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
Borgmann, Silvia H. M.
Solid State
Intrinsic Disolution Rate
Fluvastatine Sodium Hydrates
title_short Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
title_full Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
title_fullStr Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
title_full_unstemmed Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
title_sort Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
dc.creator.none.fl_str_mv Borgmann, Silvia H. M.
Bernardi, Larissa S.
Rauber, Gabriela S.
Oliveira, Paulo R.
Campos, Carlos E.M. de
Monti, Gustavo Alberto
Cuffini, Silvia L.
Cardoso, Simone
author Borgmann, Silvia H. M.
author_facet Borgmann, Silvia H. M.
Bernardi, Larissa S.
Rauber, Gabriela S.
Oliveira, Paulo R.
Campos, Carlos E.M. de
Monti, Gustavo Alberto
Cuffini, Silvia L.
Cardoso, Simone
author_role author
author2 Bernardi, Larissa S.
Rauber, Gabriela S.
Oliveira, Paulo R.
Campos, Carlos E.M. de
Monti, Gustavo Alberto
Cuffini, Silvia L.
Cardoso, Simone
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Solid State
Intrinsic Disolution Rate
Fluvastatine Sodium Hydrates
topic Solid State
Intrinsic Disolution Rate
Fluvastatine Sodium Hydrates
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate.
Fil: Borgmann, Silvia H. M.. Universidade Federal de Santa Catarina; Brasil
Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil
Fil: Rauber, Gabriela S.. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo R.. Universidade Federal de Santa Catarina; Brasil
Fil: Campos, Carlos E.M. de. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuffini, Silvia L.. Universidade Federal de Santa Catarina; Brasil
Fil: Cardoso, Simone. Universidade Federal de Santa Catarina; Brasil
description The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. FLV samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and FluvastatinACN were identified as “form I” hydrate, the USP reference standard as “form II” hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25517
Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; et al.; Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates; Taylor & Francis; Pharmaceutical Development and Technology; 18; 2; 10-2012; 525-534
1083-7450
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25517
identifier_str_mv Borgmann, Silvia H. M.; Bernardi, Larissa S.; Rauber, Gabriela S.; Oliveira, Paulo R.; Campos, Carlos E.M. de; et al.; Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates; Taylor & Francis; Pharmaceutical Development and Technology; 18; 2; 10-2012; 525-534
1083-7450
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/10837450.2012.727000
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727000
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432