Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study

Autores
Speisky, Daniela Lorena; Táquez Delgado, Mónica Alejandra; Iotti, Alejandro; Nicoud, Melisa Beatriz; Ospital, Ignacio Agustin; Vigovich, Félix; Dezanzo, Pablo; Ernst, Glenda; Uriburu, Juan L.; Medina, Vanina Araceli
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. There are neither universally accepted prognostic markers nor molecular targets related to TNBC. The histamine H4 receptor (H4R) has been characterized in TNBC experimental models, demonstrating its critical role in tumor development and progression. In this study, H4R expression was compared in breast cancer subtypes and correlated with clinical features using The Cancer Genome Atlas data (Pan-Cancer Atlas). The H4R status was further evaluated by immunohistochemistry in 30 TNBC human samples in relation to clinicopathological parameters. Results indicate that H4R was downregulated in basal-like/TNBC compared with luminal A and normal breast-like tumors. The higher expression of H4R was associated with improved progression-free and overall survival outcomes in basal-like/TNBC. H4R immunoreactivity was detected in about 70% of tumors, and its expression was positively correlated with the levels in the histologically normal peritumoral tissue. High H4R expression in peritumoral tissue correlated with reduced number of lymph node involvement and unifocal TNBC, while it was associated with increased patient survival. In conclusion, the H4R might represent a potential prognostic biomarker in TNBC. Further studies in large cohorts are needed to better understand the significance of H4R in breast cancer biology.
Fil: Speisky, Daniela Lorena. No especifíca;
Fil: Táquez Delgado, Mónica Alejandra. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Iotti, Alejandro. No especifíca;
Fil: Nicoud, Melisa Beatriz. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Ospital, Ignacio Agustin. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigovich, Félix. No especifíca;
Fil: Dezanzo, Pablo. No especifíca;
Fil: Ernst, Glenda. No especifíca;
Fil: Uriburu, Juan L.. No especifíca;
Fil: Medina, Vanina Araceli. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Materia
HISTAMINE H4 RECEPTOR
IMMUNOHISTOCHEMISTRY
METASTASIS
PROGNOSTIC MARKER
TRIPLE-NEGATIVE BREAST CANCER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216322
Acceder
id CONICETDig_0933bd54b7f82b26877506a3455bd22c
oai_identifier_str oai:ri.conicet.gov.ar:11336/216322
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory StudySpeisky, Daniela LorenaTáquez Delgado, Mónica AlejandraIotti, AlejandroNicoud, Melisa BeatrizOspital, Ignacio AgustinVigovich, FélixDezanzo, PabloErnst, GlendaUriburu, Juan L.Medina, Vanina AraceliHISTAMINE H4 RECEPTORIMMUNOHISTOCHEMISTRYMETASTASISPROGNOSTIC MARKERTRIPLE-NEGATIVE BREAST CANCERhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. There are neither universally accepted prognostic markers nor molecular targets related to TNBC. The histamine H4 receptor (H4R) has been characterized in TNBC experimental models, demonstrating its critical role in tumor development and progression. In this study, H4R expression was compared in breast cancer subtypes and correlated with clinical features using The Cancer Genome Atlas data (Pan-Cancer Atlas). The H4R status was further evaluated by immunohistochemistry in 30 TNBC human samples in relation to clinicopathological parameters. Results indicate that H4R was downregulated in basal-like/TNBC compared with luminal A and normal breast-like tumors. The higher expression of H4R was associated with improved progression-free and overall survival outcomes in basal-like/TNBC. H4R immunoreactivity was detected in about 70% of tumors, and its expression was positively correlated with the levels in the histologically normal peritumoral tissue. High H4R expression in peritumoral tissue correlated with reduced number of lymph node involvement and unifocal TNBC, while it was associated with increased patient survival. In conclusion, the H4R might represent a potential prognostic biomarker in TNBC. Further studies in large cohorts are needed to better understand the significance of H4R in breast cancer biology.Fil: Speisky, Daniela Lorena. No especifíca;Fil: Táquez Delgado, Mónica Alejandra. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Iotti, Alejandro. No especifíca;Fil: Nicoud, Melisa Beatriz. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Ospital, Ignacio Agustin. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Vigovich, Félix. No especifíca;Fil: Dezanzo, Pablo. No especifíca;Fil: Ernst, Glenda. No especifíca;Fil: Uriburu, Juan L.. No especifíca;Fil: Medina, Vanina Araceli. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaHistochemical Society2022-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216322Speisky, Daniela Lorena; Táquez Delgado, Mónica Alejandra; Iotti, Alejandro; Nicoud, Melisa Beatriz; Ospital, Ignacio Agustin; et al.; Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study; Histochemical Society; The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society; 70; 4; 4-2022; 311-3220022-1554CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1369/00221554221083670info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:34Zoai:ri.conicet.gov.ar:11336/216322instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:34.327CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
title Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
spellingShingle Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
Speisky, Daniela Lorena
HISTAMINE H4 RECEPTOR
IMMUNOHISTOCHEMISTRY
METASTASIS
PROGNOSTIC MARKER
TRIPLE-NEGATIVE BREAST CANCER
title_short Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
title_full Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
title_fullStr Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
title_full_unstemmed Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
title_sort Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study
dc.creator.none.fl_str_mv Speisky, Daniela Lorena
Táquez Delgado, Mónica Alejandra
Iotti, Alejandro
Nicoud, Melisa Beatriz
Ospital, Ignacio Agustin
Vigovich, Félix
Dezanzo, Pablo
Ernst, Glenda
Uriburu, Juan L.
Medina, Vanina Araceli
author Speisky, Daniela Lorena
author_facet Speisky, Daniela Lorena
Táquez Delgado, Mónica Alejandra
Iotti, Alejandro
Nicoud, Melisa Beatriz
Ospital, Ignacio Agustin
Vigovich, Félix
Dezanzo, Pablo
Ernst, Glenda
Uriburu, Juan L.
Medina, Vanina Araceli
author_role author
author2 Táquez Delgado, Mónica Alejandra
Iotti, Alejandro
Nicoud, Melisa Beatriz
Ospital, Ignacio Agustin
Vigovich, Félix
Dezanzo, Pablo
Ernst, Glenda
Uriburu, Juan L.
Medina, Vanina Araceli
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HISTAMINE H4 RECEPTOR
IMMUNOHISTOCHEMISTRY
METASTASIS
PROGNOSTIC MARKER
TRIPLE-NEGATIVE BREAST CANCER
topic HISTAMINE H4 RECEPTOR
IMMUNOHISTOCHEMISTRY
METASTASIS
PROGNOSTIC MARKER
TRIPLE-NEGATIVE BREAST CANCER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. There are neither universally accepted prognostic markers nor molecular targets related to TNBC. The histamine H4 receptor (H4R) has been characterized in TNBC experimental models, demonstrating its critical role in tumor development and progression. In this study, H4R expression was compared in breast cancer subtypes and correlated with clinical features using The Cancer Genome Atlas data (Pan-Cancer Atlas). The H4R status was further evaluated by immunohistochemistry in 30 TNBC human samples in relation to clinicopathological parameters. Results indicate that H4R was downregulated in basal-like/TNBC compared with luminal A and normal breast-like tumors. The higher expression of H4R was associated with improved progression-free and overall survival outcomes in basal-like/TNBC. H4R immunoreactivity was detected in about 70% of tumors, and its expression was positively correlated with the levels in the histologically normal peritumoral tissue. High H4R expression in peritumoral tissue correlated with reduced number of lymph node involvement and unifocal TNBC, while it was associated with increased patient survival. In conclusion, the H4R might represent a potential prognostic biomarker in TNBC. Further studies in large cohorts are needed to better understand the significance of H4R in breast cancer biology.
Fil: Speisky, Daniela Lorena. No especifíca;
Fil: Táquez Delgado, Mónica Alejandra. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Iotti, Alejandro. No especifíca;
Fil: Nicoud, Melisa Beatriz. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Ospital, Ignacio Agustin. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigovich, Félix. No especifíca;
Fil: Dezanzo, Pablo. No especifíca;
Fil: Ernst, Glenda. No especifíca;
Fil: Uriburu, Juan L.. No especifíca;
Fil: Medina, Vanina Araceli. Hospital Británico de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
description Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. There are neither universally accepted prognostic markers nor molecular targets related to TNBC. The histamine H4 receptor (H4R) has been characterized in TNBC experimental models, demonstrating its critical role in tumor development and progression. In this study, H4R expression was compared in breast cancer subtypes and correlated with clinical features using The Cancer Genome Atlas data (Pan-Cancer Atlas). The H4R status was further evaluated by immunohistochemistry in 30 TNBC human samples in relation to clinicopathological parameters. Results indicate that H4R was downregulated in basal-like/TNBC compared with luminal A and normal breast-like tumors. The higher expression of H4R was associated with improved progression-free and overall survival outcomes in basal-like/TNBC. H4R immunoreactivity was detected in about 70% of tumors, and its expression was positively correlated with the levels in the histologically normal peritumoral tissue. High H4R expression in peritumoral tissue correlated with reduced number of lymph node involvement and unifocal TNBC, while it was associated with increased patient survival. In conclusion, the H4R might represent a potential prognostic biomarker in TNBC. Further studies in large cohorts are needed to better understand the significance of H4R in breast cancer biology.
publishDate 2022
dc.date.none.fl_str_mv 2022-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216322
Speisky, Daniela Lorena; Táquez Delgado, Mónica Alejandra; Iotti, Alejandro; Nicoud, Melisa Beatriz; Ospital, Ignacio Agustin; et al.; Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study; Histochemical Society; The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society; 70; 4; 4-2022; 311-322
0022-1554
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216322
identifier_str_mv Speisky, Daniela Lorena; Táquez Delgado, Mónica Alejandra; Iotti, Alejandro; Nicoud, Melisa Beatriz; Ospital, Ignacio Agustin; et al.; Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study; Histochemical Society; The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society; 70; 4; 4-2022; 311-322
0022-1554
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1369/00221554221083670
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Histochemical Society
publisher.none.fl_str_mv Histochemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269167744450560
score 13.13397

Publicaciones similares