Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation

Autores
Zuchuat, Jésica Itatí; Halter, Christian; Zalazar, Martin
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Electric fields used in bone stimulation are based on the application of direct current, but some drawbacks exist, such as the need for an external power source. Piezoelectric poly(vinylidene fluoride) (PVDF) has attracted interest for biomedical applications due to its flexibility, low toxicity, and the piezoelectric response to mechanical stimuli. This study aimed to investigate the effects of PVDF films on bone regeneration in rabbit tibias to assess the potential improvement in osteogenesis. An initial exploratory experiment was performed to determine optimal parameters for regulating the marrow blood supply. The second experiment focused on examining the effects of ultrasound stimulation on the implant's osteogenic capacity. The results showed that PVDF films have a notable impact on the extraskeletal bone formation and bone density in a secluded microenvironment with and without microperforations. At 60 days after surgery, tibias with marrow blood supply reached higher bone volumes and density and they were consistent with the cellular activity. Our results suggest that piezoelectric PVDF films have osteogenic characteristics and can be used to enhance new bone formation in a secluded space, thus reinforcing their biocompatibility nature. Additional studies are required to analyze the benefits of ultrasound stimulation.
Fil: Zuchuat, Jésica Itatí. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
Fil: Halter, Christian. Universidad Nacional de Entre Ríos; Argentina
Fil: Zalazar, Martin. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
Materia
BONE TISSUE ENGINEERING
OSTEOGENESIS
PIEZOELECTRIC
POLYVINYLIDENE FLUORIDE
ULTRASOUND
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225847
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulationZuchuat, Jésica ItatíHalter, ChristianZalazar, MartinBONE TISSUE ENGINEERINGOSTEOGENESISPIEZOELECTRICPOLYVINYLIDENE FLUORIDEULTRASOUNDhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Electric fields used in bone stimulation are based on the application of direct current, but some drawbacks exist, such as the need for an external power source. Piezoelectric poly(vinylidene fluoride) (PVDF) has attracted interest for biomedical applications due to its flexibility, low toxicity, and the piezoelectric response to mechanical stimuli. This study aimed to investigate the effects of PVDF films on bone regeneration in rabbit tibias to assess the potential improvement in osteogenesis. An initial exploratory experiment was performed to determine optimal parameters for regulating the marrow blood supply. The second experiment focused on examining the effects of ultrasound stimulation on the implant's osteogenic capacity. The results showed that PVDF films have a notable impact on the extraskeletal bone formation and bone density in a secluded microenvironment with and without microperforations. At 60 days after surgery, tibias with marrow blood supply reached higher bone volumes and density and they were consistent with the cellular activity. Our results suggest that piezoelectric PVDF films have osteogenic characteristics and can be used to enhance new bone formation in a secluded space, thus reinforcing their biocompatibility nature. Additional studies are required to analyze the benefits of ultrasound stimulation.Fil: Zuchuat, Jésica Itatí. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; ArgentinaFil: Halter, Christian. Universidad Nacional de Entre Ríos; ArgentinaFil: Zalazar, Martin. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; ArgentinaJohn Wiley & Sons2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225847Zuchuat, Jésica Itatí; Halter, Christian; Zalazar, Martin; Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation; John Wiley & Sons; SPE Polymers; 4; 4; 7-2023; 175-1852690-3857CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://4spepublications.onlinelibrary.wiley.com/doi/10.1002/pls2.10099info:eu-repo/semantics/altIdentifier/doi/10.1002/pls2.10099info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:04:29Zoai:ri.conicet.gov.ar:11336/225847instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:04:29.492CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
title Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
spellingShingle Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
Zuchuat, Jésica Itatí
BONE TISSUE ENGINEERING
OSTEOGENESIS
PIEZOELECTRIC
POLYVINYLIDENE FLUORIDE
ULTRASOUND
title_short Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
title_full Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
title_fullStr Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
title_full_unstemmed Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
title_sort Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation
dc.creator.none.fl_str_mv Zuchuat, Jésica Itatí
Halter, Christian
Zalazar, Martin
author Zuchuat, Jésica Itatí
author_facet Zuchuat, Jésica Itatí
Halter, Christian
Zalazar, Martin
author_role author
author2 Halter, Christian
Zalazar, Martin
author2_role author
author
dc.subject.none.fl_str_mv BONE TISSUE ENGINEERING
OSTEOGENESIS
PIEZOELECTRIC
POLYVINYLIDENE FLUORIDE
ULTRASOUND
topic BONE TISSUE ENGINEERING
OSTEOGENESIS
PIEZOELECTRIC
POLYVINYLIDENE FLUORIDE
ULTRASOUND
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Electric fields used in bone stimulation are based on the application of direct current, but some drawbacks exist, such as the need for an external power source. Piezoelectric poly(vinylidene fluoride) (PVDF) has attracted interest for biomedical applications due to its flexibility, low toxicity, and the piezoelectric response to mechanical stimuli. This study aimed to investigate the effects of PVDF films on bone regeneration in rabbit tibias to assess the potential improvement in osteogenesis. An initial exploratory experiment was performed to determine optimal parameters for regulating the marrow blood supply. The second experiment focused on examining the effects of ultrasound stimulation on the implant's osteogenic capacity. The results showed that PVDF films have a notable impact on the extraskeletal bone formation and bone density in a secluded microenvironment with and without microperforations. At 60 days after surgery, tibias with marrow blood supply reached higher bone volumes and density and they were consistent with the cellular activity. Our results suggest that piezoelectric PVDF films have osteogenic characteristics and can be used to enhance new bone formation in a secluded space, thus reinforcing their biocompatibility nature. Additional studies are required to analyze the benefits of ultrasound stimulation.
Fil: Zuchuat, Jésica Itatí. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
Fil: Halter, Christian. Universidad Nacional de Entre Ríos; Argentina
Fil: Zalazar, Martin. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
description Electric fields used in bone stimulation are based on the application of direct current, but some drawbacks exist, such as the need for an external power source. Piezoelectric poly(vinylidene fluoride) (PVDF) has attracted interest for biomedical applications due to its flexibility, low toxicity, and the piezoelectric response to mechanical stimuli. This study aimed to investigate the effects of PVDF films on bone regeneration in rabbit tibias to assess the potential improvement in osteogenesis. An initial exploratory experiment was performed to determine optimal parameters for regulating the marrow blood supply. The second experiment focused on examining the effects of ultrasound stimulation on the implant's osteogenic capacity. The results showed that PVDF films have a notable impact on the extraskeletal bone formation and bone density in a secluded microenvironment with and without microperforations. At 60 days after surgery, tibias with marrow blood supply reached higher bone volumes and density and they were consistent with the cellular activity. Our results suggest that piezoelectric PVDF films have osteogenic characteristics and can be used to enhance new bone formation in a secluded space, thus reinforcing their biocompatibility nature. Additional studies are required to analyze the benefits of ultrasound stimulation.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225847
Zuchuat, Jésica Itatí; Halter, Christian; Zalazar, Martin; Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation; John Wiley & Sons; SPE Polymers; 4; 4; 7-2023; 175-185
2690-3857
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225847
identifier_str_mv Zuchuat, Jésica Itatí; Halter, Christian; Zalazar, Martin; Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation; John Wiley & Sons; SPE Polymers; 4; 4; 7-2023; 175-185
2690-3857
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://4spepublications.onlinelibrary.wiley.com/doi/10.1002/pls2.10099
info:eu-repo/semantics/altIdentifier/doi/10.1002/pls2.10099
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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