Lipid peroxidation of membrane phospholipids in the vertebrate retina

Autores
Catala, Angel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Retina is very rich in membranes containing polyunsaturated fatty acids. Reactive oxygen species initiates chain reactions of lipid peroxidation which injure the retina, especially the membranes that play important roles in visual function. Furthermore, biomolecules such as proteins or amino lipids can be covalently modified by lipid decomposition products. In retinal membranes, peroxidation of lipids is also usually accompanied by oxidation of membrane proteins. In consequence, lipid peroxidation may alter the arrangement of proteins in bilayers and by that interfere with their physiological role on the membrane function. Here, we review several studies on the lipid peroxidation of membrane phospholipids in retina. Particular emphasis is placed on the molecular changes of very long chain polyunsaturated fatty acids associated with protein modifications during peroxidation of photoreceptor membranes. Furthermore we use liposomes to analyze peroxidation of retinal lipids. Conjugated dienes formed from oxidized PUFAs, and TBARS products derived from the breakdown of these fatty acids located in phospholipids can be analyzed during lipid peroxidation of liposomes made of retinal lipids using Fe2+ and Fe3+ as initiators.
Fil: Catala, Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Materia
retina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271425
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Lipid peroxidation of membrane phospholipids in the vertebrate retinaCatala, Angelretinahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Retina is very rich in membranes containing polyunsaturated fatty acids. Reactive oxygen species initiates chain reactions of lipid peroxidation which injure the retina, especially the membranes that play important roles in visual function. Furthermore, biomolecules such as proteins or amino lipids can be covalently modified by lipid decomposition products. In retinal membranes, peroxidation of lipids is also usually accompanied by oxidation of membrane proteins. In consequence, lipid peroxidation may alter the arrangement of proteins in bilayers and by that interfere with their physiological role on the membrane function. Here, we review several studies on the lipid peroxidation of membrane phospholipids in retina. Particular emphasis is placed on the molecular changes of very long chain polyunsaturated fatty acids associated with protein modifications during peroxidation of photoreceptor membranes. Furthermore we use liposomes to analyze peroxidation of retinal lipids. Conjugated dienes formed from oxidized PUFAs, and TBARS products derived from the breakdown of these fatty acids located in phospholipids can be analyzed during lipid peroxidation of liposomes made of retinal lipids using Fe2+ and Fe3+ as initiators.Fil: Catala, Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFrontiers in Bioscience2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/271425Catala, Angel; Lipid peroxidation of membrane phospholipids in the vertebrate retina; Frontiers in Bioscience; Frontiers in Bioscience; S3; 1; 1-2011; 52-601093-47151945-0524CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2741/s131info:eu-repo/semantics/altIdentifier/url/https://www.imrpress.com/journal/FBS/3/1/10.2741/S131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:18Zoai:ri.conicet.gov.ar:11336/271425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:18.811CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lipid peroxidation of membrane phospholipids in the vertebrate retina
title Lipid peroxidation of membrane phospholipids in the vertebrate retina
spellingShingle Lipid peroxidation of membrane phospholipids in the vertebrate retina
Catala, Angel
retina
title_short Lipid peroxidation of membrane phospholipids in the vertebrate retina
title_full Lipid peroxidation of membrane phospholipids in the vertebrate retina
title_fullStr Lipid peroxidation of membrane phospholipids in the vertebrate retina
title_full_unstemmed Lipid peroxidation of membrane phospholipids in the vertebrate retina
title_sort Lipid peroxidation of membrane phospholipids in the vertebrate retina
dc.creator.none.fl_str_mv Catala, Angel
author Catala, Angel
author_facet Catala, Angel
author_role author
dc.subject.none.fl_str_mv retina
topic retina
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Retina is very rich in membranes containing polyunsaturated fatty acids. Reactive oxygen species initiates chain reactions of lipid peroxidation which injure the retina, especially the membranes that play important roles in visual function. Furthermore, biomolecules such as proteins or amino lipids can be covalently modified by lipid decomposition products. In retinal membranes, peroxidation of lipids is also usually accompanied by oxidation of membrane proteins. In consequence, lipid peroxidation may alter the arrangement of proteins in bilayers and by that interfere with their physiological role on the membrane function. Here, we review several studies on the lipid peroxidation of membrane phospholipids in retina. Particular emphasis is placed on the molecular changes of very long chain polyunsaturated fatty acids associated with protein modifications during peroxidation of photoreceptor membranes. Furthermore we use liposomes to analyze peroxidation of retinal lipids. Conjugated dienes formed from oxidized PUFAs, and TBARS products derived from the breakdown of these fatty acids located in phospholipids can be analyzed during lipid peroxidation of liposomes made of retinal lipids using Fe2+ and Fe3+ as initiators.
Fil: Catala, Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
description Retina is very rich in membranes containing polyunsaturated fatty acids. Reactive oxygen species initiates chain reactions of lipid peroxidation which injure the retina, especially the membranes that play important roles in visual function. Furthermore, biomolecules such as proteins or amino lipids can be covalently modified by lipid decomposition products. In retinal membranes, peroxidation of lipids is also usually accompanied by oxidation of membrane proteins. In consequence, lipid peroxidation may alter the arrangement of proteins in bilayers and by that interfere with their physiological role on the membrane function. Here, we review several studies on the lipid peroxidation of membrane phospholipids in retina. Particular emphasis is placed on the molecular changes of very long chain polyunsaturated fatty acids associated with protein modifications during peroxidation of photoreceptor membranes. Furthermore we use liposomes to analyze peroxidation of retinal lipids. Conjugated dienes formed from oxidized PUFAs, and TBARS products derived from the breakdown of these fatty acids located in phospholipids can be analyzed during lipid peroxidation of liposomes made of retinal lipids using Fe2+ and Fe3+ as initiators.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271425
Catala, Angel; Lipid peroxidation of membrane phospholipids in the vertebrate retina; Frontiers in Bioscience; Frontiers in Bioscience; S3; 1; 1-2011; 52-60
1093-4715
1945-0524
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271425
identifier_str_mv Catala, Angel; Lipid peroxidation of membrane phospholipids in the vertebrate retina; Frontiers in Bioscience; Frontiers in Bioscience; S3; 1; 1-2011; 52-60
1093-4715
1945-0524
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2741/s131
info:eu-repo/semantics/altIdentifier/url/https://www.imrpress.com/journal/FBS/3/1/10.2741/S131
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience
publisher.none.fl_str_mv Frontiers in Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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