Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"

Autores
Catalá, Ángel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind, I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by cholesterol and fatty acids; the "Lipid Whisker Model" and finally analyzed the changes induced by lipid peroxidation in membrane structure and dynamics, both at the lipid and protein level. Several reviews have appeared in recent years related to the kinetics and biology of lipid peroxidation products (Catala, 2010; Yin et al., 2011; Pinchuk and Lichtenberg, 2014; Vigor et al., 2014; Davies and Guo, 2014). The analysis of lipid peroxidation products has been particularly important in the advancement of research in this field because of the complexity of product mixtures. I also discuss the effect of other membrane modifications, triggered by lipid peroxidation products and reducing sugars. Contrary to what is expected by the LWM, Garrec et al. (2014) have recently investigated the validity of the "floating peroxyl radical" hypothesis by means of molecular modeling and predicted that the peroxyl radical does not "float" at the surface of the membrane.
Facultad de Ciencias Exactas
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86114
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/86114
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"Catalá, ÁngelCiencias ExactasFluid mosaic modelLipid peroxidationLipid whisker modelMembranesPUFAsThe aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind, I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by cholesterol and fatty acids; the "Lipid Whisker Model" and finally analyzed the changes induced by lipid peroxidation in membrane structure and dynamics, both at the lipid and protein level. Several reviews have appeared in recent years related to the kinetics and biology of lipid peroxidation products (Catala, 2010; Yin et al., 2011; Pinchuk and Lichtenberg, 2014; Vigor et al., 2014; Davies and Guo, 2014). The analysis of lipid peroxidation products has been particularly important in the advancement of research in this field because of the complexity of product mixtures. I also discuss the effect of other membrane modifications, triggered by lipid peroxidation products and reducing sugars. Contrary to what is expected by the LWM, Garrec et al. (2014) have recently investigated the validity of the "floating peroxyl radical" hypothesis by means of molecular modeling and predicted that the peroxyl radical does not "float" at the surface of the membrane.Facultad de Ciencias ExactasInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/86114enginfo:eu-repo/semantics/altIdentifier/issn/1664-042Xinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2014.00520info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:08:55Zoai:sedici.unlp.edu.ar:10915/86114Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:08:55.582SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
spellingShingle Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
Catalá, Ángel
Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
title_short Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_full Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_fullStr Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_full_unstemmed Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_sort Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
dc.creator.none.fl_str_mv Catalá, Ángel
author Catalá, Ángel
author_facet Catalá, Ángel
author_role author
dc.subject.none.fl_str_mv Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
topic Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
dc.description.none.fl_txt_mv The aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind, I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by cholesterol and fatty acids; the "Lipid Whisker Model" and finally analyzed the changes induced by lipid peroxidation in membrane structure and dynamics, both at the lipid and protein level. Several reviews have appeared in recent years related to the kinetics and biology of lipid peroxidation products (Catala, 2010; Yin et al., 2011; Pinchuk and Lichtenberg, 2014; Vigor et al., 2014; Davies and Guo, 2014). The analysis of lipid peroxidation products has been particularly important in the advancement of research in this field because of the complexity of product mixtures. I also discuss the effect of other membrane modifications, triggered by lipid peroxidation products and reducing sugars. Contrary to what is expected by the LWM, Garrec et al. (2014) have recently investigated the validity of the "floating peroxyl radical" hypothesis by means of molecular modeling and predicted that the peroxyl radical does not "float" at the surface of the membrane.
Facultad de Ciencias Exactas
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description The aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind, I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by cholesterol and fatty acids; the "Lipid Whisker Model" and finally analyzed the changes induced by lipid peroxidation in membrane structure and dynamics, both at the lipid and protein level. Several reviews have appeared in recent years related to the kinetics and biology of lipid peroxidation products (Catala, 2010; Yin et al., 2011; Pinchuk and Lichtenberg, 2014; Vigor et al., 2014; Davies and Guo, 2014). The analysis of lipid peroxidation products has been particularly important in the advancement of research in this field because of the complexity of product mixtures. I also discuss the effect of other membrane modifications, triggered by lipid peroxidation products and reducing sugars. Contrary to what is expected by the LWM, Garrec et al. (2014) have recently investigated the validity of the "floating peroxyl radical" hypothesis by means of molecular modeling and predicted that the peroxyl radical does not "float" at the surface of the membrane.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86114
url http://sedici.unlp.edu.ar/handle/10915/86114
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1664-042X
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2014.00520
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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