Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)

Autores
Miceli, Diego Daniel; Niessen, Stijn J M; Rey Amunategui, Juan P.; Zeugswetter, Florian K.; Pompili, Gustavo; Tavares, Flavia; Molina, Estela; Leal, Rodolfo; Espiñeira, Ignacio; Bota, Doroteia; Corsini, Andrea; Fracassi, Federico
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Hypersomatotropism (HST) in cats has predominantly been associated with diabetes mellitus (DM) and HST in nondiabetic cats is poorly described. Hypothesis/Objectives: To describe the clinical presentation, clinicopathologic findings, and outcome of nondiabetic cats with presumed HST. Animals: Twenty-eight client-owned cats. Methods: Multi-site retrospective study based on medical records of nondiabetic cats seen at 10 institutions between 2014 and 2024 with presumed HST (elevated serum insulin-like growth factor-1 [IGF-1] ± clinical signs compatible with acromegaly ± documented pituitary enlargement). Clinical presentation, diagnostic findings, and survival times were reviewed. Results: Twenty-eight cats with HST were included. Twenty-six cats were males, and 2 cats were females; mean age was 9.5 years (±SD 3.5 years); mean body weight was 7.1 kg (±SD 2.1 kg). The median serum IGF-1 concentration was 1236 ng/mL (range 704-2455 ng/mL). Nineteen of 28 cats (68%) had clinical signs possibly related to acromegaly: prognathia inferior (13/28), weight gain (12/28), broad facial features (10/28), abdominal enlargement (10/28), respiratory stridor (9/28), polyphagia (9/28), and signs of neurological disease (3/28). The most common clinicopathological abnormalities were hyperproteinemia (12/28), serum creatinine above the reference interval (RI) (10/28), and urinary specific gravity below the RI (9/28). Hypertrophic cardiomyopathy phenotype was identified in 8/17 cases. The most common comorbidity was chronic kidney disease (10/28). The median survival time after diagnosis was 24 months (range 1-103 months). Conclusions and clinical importance:Hypersomatotropism can present without DM and should be considered in cats with signs suggestive of growth hormone excess or a pituitary tumor.
Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Niessen, Stijn J M. University of London; Reino Unido. Michigan State University; Estados Unidos. Veterinary Specialist Consultations & VIN Europe; Países Bajos
Fil: Rey Amunategui, Juan P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Zeugswetter, Florian K.. University of Veterinary Medicine; Austria
Fil: Pompili, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Tavares, Flavia. E + VET Clinic; Brasil
Fil: Molina, Estela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Leal, Rodolfo. Universidade Nova de Lisboa; Portugal. Associate Laboratory for Animal and Veterinary Sciences; Portugal
Fil: Espiñeira, Ignacio. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Bota, Doroteia. AniCura Restelo Veterinary Hospital; Portugal
Fil: Corsini, Andrea. Università di Parma; Italia
Fil: Fracassi, Federico. Universidad de Bologna; Italia
Materia
ACROMEGALY
CATS
GH EXCESS
NONDIABETIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/289031
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/289031
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)Miceli, Diego DanielNiessen, Stijn J MRey Amunategui, Juan P.Zeugswetter, Florian K.Pompili, GustavoTavares, FlaviaMolina, EstelaLeal, RodolfoEspiñeira, IgnacioBota, DoroteiaCorsini, AndreaFracassi, FedericoACROMEGALYCATSGH EXCESSNONDIABETIChttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Background: Hypersomatotropism (HST) in cats has predominantly been associated with diabetes mellitus (DM) and HST in nondiabetic cats is poorly described. Hypothesis/Objectives: To describe the clinical presentation, clinicopathologic findings, and outcome of nondiabetic cats with presumed HST. Animals: Twenty-eight client-owned cats. Methods: Multi-site retrospective study based on medical records of nondiabetic cats seen at 10 institutions between 2014 and 2024 with presumed HST (elevated serum insulin-like growth factor-1 [IGF-1] ± clinical signs compatible with acromegaly ± documented pituitary enlargement). Clinical presentation, diagnostic findings, and survival times were reviewed. Results: Twenty-eight cats with HST were included. Twenty-six cats were males, and 2 cats were females; mean age was 9.5 years (±SD 3.5 years); mean body weight was 7.1 kg (±SD 2.1 kg). The median serum IGF-1 concentration was 1236 ng/mL (range 704-2455 ng/mL). Nineteen of 28 cats (68%) had clinical signs possibly related to acromegaly: prognathia inferior (13/28), weight gain (12/28), broad facial features (10/28), abdominal enlargement (10/28), respiratory stridor (9/28), polyphagia (9/28), and signs of neurological disease (3/28). The most common clinicopathological abnormalities were hyperproteinemia (12/28), serum creatinine above the reference interval (RI) (10/28), and urinary specific gravity below the RI (9/28). Hypertrophic cardiomyopathy phenotype was identified in 8/17 cases. The most common comorbidity was chronic kidney disease (10/28). The median survival time after diagnosis was 24 months (range 1-103 months). Conclusions and clinical importance:Hypersomatotropism can present without DM and should be considered in cats with signs suggestive of growth hormone excess or a pituitary tumor.Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Niessen, Stijn J M. University of London; Reino Unido. Michigan State University; Estados Unidos. Veterinary Specialist Consultations & VIN Europe; Países BajosFil: Rey Amunategui, Juan P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Zeugswetter, Florian K.. University of Veterinary Medicine; AustriaFil: Pompili, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Tavares, Flavia. E + VET Clinic; BrasilFil: Molina, Estela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Leal, Rodolfo. Universidade Nova de Lisboa; Portugal. Associate Laboratory for Animal and Veterinary Sciences; PortugalFil: Espiñeira, Ignacio. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Bota, Doroteia. AniCura Restelo Veterinary Hospital; PortugalFil: Corsini, Andrea. Università di Parma; ItaliaFil: Fracassi, Federico. Universidad de Bologna; ItaliaOxford University Press2026-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/289031Miceli, Diego Daniel; Niessen, Stijn J M; Rey Amunategui, Juan P.; Zeugswetter, Florian K.; Pompili, Gustavo; et al.; Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024); Oxford University Press; Journal of Veterinary Internal Medicine; 40; 1; 1-2026; 1-91939-1676CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jvim/article/40/1/aalaf050/8429749info:eu-repo/semantics/altIdentifier/doi/10.1093/jvimsj/aalaf050info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-06-17T09:42:12Zoai:ri.conicet.gov.ar:11336/289031instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-06-17 09:42:12.498CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
title Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
spellingShingle Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
Miceli, Diego Daniel
ACROMEGALY
CATS
GH EXCESS
NONDIABETIC
title_short Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
title_full Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
title_fullStr Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
title_full_unstemmed Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
title_sort Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)
dc.creator.none.fl_str_mv Miceli, Diego Daniel
Niessen, Stijn J M
Rey Amunategui, Juan P.
Zeugswetter, Florian K.
Pompili, Gustavo
Tavares, Flavia
Molina, Estela
Leal, Rodolfo
Espiñeira, Ignacio
Bota, Doroteia
Corsini, Andrea
Fracassi, Federico
author Miceli, Diego Daniel
author_facet Miceli, Diego Daniel
Niessen, Stijn J M
Rey Amunategui, Juan P.
Zeugswetter, Florian K.
Pompili, Gustavo
Tavares, Flavia
Molina, Estela
Leal, Rodolfo
Espiñeira, Ignacio
Bota, Doroteia
Corsini, Andrea
Fracassi, Federico
author_role author
author2 Niessen, Stijn J M
Rey Amunategui, Juan P.
Zeugswetter, Florian K.
Pompili, Gustavo
Tavares, Flavia
Molina, Estela
Leal, Rodolfo
Espiñeira, Ignacio
Bota, Doroteia
Corsini, Andrea
Fracassi, Federico
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACROMEGALY
CATS
GH EXCESS
NONDIABETIC
topic ACROMEGALY
CATS
GH EXCESS
NONDIABETIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Background: Hypersomatotropism (HST) in cats has predominantly been associated with diabetes mellitus (DM) and HST in nondiabetic cats is poorly described. Hypothesis/Objectives: To describe the clinical presentation, clinicopathologic findings, and outcome of nondiabetic cats with presumed HST. Animals: Twenty-eight client-owned cats. Methods: Multi-site retrospective study based on medical records of nondiabetic cats seen at 10 institutions between 2014 and 2024 with presumed HST (elevated serum insulin-like growth factor-1 [IGF-1] ± clinical signs compatible with acromegaly ± documented pituitary enlargement). Clinical presentation, diagnostic findings, and survival times were reviewed. Results: Twenty-eight cats with HST were included. Twenty-six cats were males, and 2 cats were females; mean age was 9.5 years (±SD 3.5 years); mean body weight was 7.1 kg (±SD 2.1 kg). The median serum IGF-1 concentration was 1236 ng/mL (range 704-2455 ng/mL). Nineteen of 28 cats (68%) had clinical signs possibly related to acromegaly: prognathia inferior (13/28), weight gain (12/28), broad facial features (10/28), abdominal enlargement (10/28), respiratory stridor (9/28), polyphagia (9/28), and signs of neurological disease (3/28). The most common clinicopathological abnormalities were hyperproteinemia (12/28), serum creatinine above the reference interval (RI) (10/28), and urinary specific gravity below the RI (9/28). Hypertrophic cardiomyopathy phenotype was identified in 8/17 cases. The most common comorbidity was chronic kidney disease (10/28). The median survival time after diagnosis was 24 months (range 1-103 months). Conclusions and clinical importance:Hypersomatotropism can present without DM and should be considered in cats with signs suggestive of growth hormone excess or a pituitary tumor.
Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Niessen, Stijn J M. University of London; Reino Unido. Michigan State University; Estados Unidos. Veterinary Specialist Consultations & VIN Europe; Países Bajos
Fil: Rey Amunategui, Juan P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Zeugswetter, Florian K.. University of Veterinary Medicine; Austria
Fil: Pompili, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Tavares, Flavia. E + VET Clinic; Brasil
Fil: Molina, Estela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Leal, Rodolfo. Universidade Nova de Lisboa; Portugal. Associate Laboratory for Animal and Veterinary Sciences; Portugal
Fil: Espiñeira, Ignacio. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Bota, Doroteia. AniCura Restelo Veterinary Hospital; Portugal
Fil: Corsini, Andrea. Università di Parma; Italia
Fil: Fracassi, Federico. Universidad de Bologna; Italia
description Background: Hypersomatotropism (HST) in cats has predominantly been associated with diabetes mellitus (DM) and HST in nondiabetic cats is poorly described. Hypothesis/Objectives: To describe the clinical presentation, clinicopathologic findings, and outcome of nondiabetic cats with presumed HST. Animals: Twenty-eight client-owned cats. Methods: Multi-site retrospective study based on medical records of nondiabetic cats seen at 10 institutions between 2014 and 2024 with presumed HST (elevated serum insulin-like growth factor-1 [IGF-1] ± clinical signs compatible with acromegaly ± documented pituitary enlargement). Clinical presentation, diagnostic findings, and survival times were reviewed. Results: Twenty-eight cats with HST were included. Twenty-six cats were males, and 2 cats were females; mean age was 9.5 years (±SD 3.5 years); mean body weight was 7.1 kg (±SD 2.1 kg). The median serum IGF-1 concentration was 1236 ng/mL (range 704-2455 ng/mL). Nineteen of 28 cats (68%) had clinical signs possibly related to acromegaly: prognathia inferior (13/28), weight gain (12/28), broad facial features (10/28), abdominal enlargement (10/28), respiratory stridor (9/28), polyphagia (9/28), and signs of neurological disease (3/28). The most common clinicopathological abnormalities were hyperproteinemia (12/28), serum creatinine above the reference interval (RI) (10/28), and urinary specific gravity below the RI (9/28). Hypertrophic cardiomyopathy phenotype was identified in 8/17 cases. The most common comorbidity was chronic kidney disease (10/28). The median survival time after diagnosis was 24 months (range 1-103 months). Conclusions and clinical importance:Hypersomatotropism can present without DM and should be considered in cats with signs suggestive of growth hormone excess or a pituitary tumor.
publishDate 2026
dc.date.none.fl_str_mv 2026-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/289031
Miceli, Diego Daniel; Niessen, Stijn J M; Rey Amunategui, Juan P.; Zeugswetter, Florian K.; Pompili, Gustavo; et al.; Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024); Oxford University Press; Journal of Veterinary Internal Medicine; 40; 1; 1-2026; 1-9
1939-1676
CONICET Digital
CONICET
url http://hdl.handle.net/11336/289031
identifier_str_mv Miceli, Diego Daniel; Niessen, Stijn J M; Rey Amunategui, Juan P.; Zeugswetter, Florian K.; Pompili, Gustavo; et al.; Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024); Oxford University Press; Journal of Veterinary Internal Medicine; 40; 1; 1-2026; 1-9
1939-1676
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jvim/article/40/1/aalaf050/8429749
info:eu-repo/semantics/altIdentifier/doi/10.1093/jvimsj/aalaf050
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.040872

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