Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
- Autores
- Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility.
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Ganzinelli, Sabrina Belen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; Argentina - Materia
-
AUTOANTIBODIES
CONTRACTILITY
HEART RATE VARIABILITY
MYOCARDIUM
PEPTIDES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/189030
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oai:ri.conicet.gov.ar:11336/189030 |
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CONICET Digital (CONICET) |
spelling |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunctionSegovia, MarcelaGanzinelli, Sabrina BelenReina, Silvia LorenaBorda, Enri SantiagoSterin Borda, LeonorAUTOANTIBODIESCONTRACTILITYHEART RATE VARIABILITYMYOCARDIUMPEPTIDEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility.Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Ganzinelli, Sabrina Belen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaWiley Blackwell Publishing, Inc2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/189030Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor; Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 41; 3; 3-2012; 242-2480904-2512CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01090.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0714.2011.01090.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:34Zoai:ri.conicet.gov.ar:11336/189030instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:34.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
title |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
spellingShingle |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction Segovia, Marcela AUTOANTIBODIES CONTRACTILITY HEART RATE VARIABILITY MYOCARDIUM PEPTIDES |
title_short |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
title_full |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
title_fullStr |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
title_full_unstemmed |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
title_sort |
Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction |
dc.creator.none.fl_str_mv |
Segovia, Marcela Ganzinelli, Sabrina Belen Reina, Silvia Lorena Borda, Enri Santiago Sterin Borda, Leonor |
author |
Segovia, Marcela |
author_facet |
Segovia, Marcela Ganzinelli, Sabrina Belen Reina, Silvia Lorena Borda, Enri Santiago Sterin Borda, Leonor |
author_role |
author |
author2 |
Ganzinelli, Sabrina Belen Reina, Silvia Lorena Borda, Enri Santiago Sterin Borda, Leonor |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
AUTOANTIBODIES CONTRACTILITY HEART RATE VARIABILITY MYOCARDIUM PEPTIDES |
topic |
AUTOANTIBODIES CONTRACTILITY HEART RATE VARIABILITY MYOCARDIUM PEPTIDES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility. Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología; Argentina Fil: Ganzinelli, Sabrina Belen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; Argentina |
description |
Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/189030 Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor; Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 41; 3; 3-2012; 242-248 0904-2512 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/189030 |
identifier_str_mv |
Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor; Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 41; 3; 3-2012; 242-248 0904-2512 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01090.x info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0714.2011.01090.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613788332982272 |
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13.070432 |