Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction

Autores
Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility.
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Ganzinelli, Sabrina Belen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Materia
AUTOANTIBODIES
CONTRACTILITY
HEART RATE VARIABILITY
MYOCARDIUM
PEPTIDES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/189030

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunctionSegovia, MarcelaGanzinelli, Sabrina BelenReina, Silvia LorenaBorda, Enri SantiagoSterin Borda, LeonorAUTOANTIBODIESCONTRACTILITYHEART RATE VARIABILITYMYOCARDIUMPEPTIDEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility.Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Ganzinelli, Sabrina Belen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaWiley Blackwell Publishing, Inc2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/189030Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor; Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 41; 3; 3-2012; 242-2480904-2512CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01090.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0714.2011.01090.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:34Zoai:ri.conicet.gov.ar:11336/189030instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:34.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
title Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
spellingShingle Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
Segovia, Marcela
AUTOANTIBODIES
CONTRACTILITY
HEART RATE VARIABILITY
MYOCARDIUM
PEPTIDES
title_short Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
title_full Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
title_fullStr Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
title_full_unstemmed Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
title_sort Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction
dc.creator.none.fl_str_mv Segovia, Marcela
Ganzinelli, Sabrina Belen
Reina, Silvia Lorena
Borda, Enri Santiago
Sterin Borda, Leonor
author Segovia, Marcela
author_facet Segovia, Marcela
Ganzinelli, Sabrina Belen
Reina, Silvia Lorena
Borda, Enri Santiago
Sterin Borda, Leonor
author_role author
author2 Ganzinelli, Sabrina Belen
Reina, Silvia Lorena
Borda, Enri Santiago
Sterin Borda, Leonor
author2_role author
author
author
author
dc.subject.none.fl_str_mv AUTOANTIBODIES
CONTRACTILITY
HEART RATE VARIABILITY
MYOCARDIUM
PEPTIDES
topic AUTOANTIBODIES
CONTRACTILITY
HEART RATE VARIABILITY
MYOCARDIUM
PEPTIDES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility.
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Ganzinelli, Sabrina Belen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin Borda, Leonor. Universidad de Buenos Aires. Facultad de Odontología; Argentina
description Background: The presence of serum autoantibodies against β 1 adrenoreceptors (β 1-ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β 1-AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β 1-AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods: An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β 1-AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results: Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β 1-AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β 1-AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β 1-AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β 1-AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion: This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β 1-AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β 1-AR autoantibody that alters myocardial contractility.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/189030
Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor; Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 41; 3; 3-2012; 242-248
0904-2512
CONICET Digital
CONICET
url http://hdl.handle.net/11336/189030
identifier_str_mv Segovia, Marcela; Ganzinelli, Sabrina Belen; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin Borda, Leonor; Role of anti-β 1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 41; 3; 3-2012; 242-248
0904-2512
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01090.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0714.2011.01090.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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