Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
- Autores
- Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility.
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina - Materia
-
AUTOANTIBODIES
PERIODONTITIS
CARDIAC FUNCTION
BETA 1 ADRENERGIC RECEPTOR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/13307
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Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac DysfunctionSegovia, MarcelaReina, Silvia LorenaBorda, Enri SantiagoSterin, Leonor JosefinaAUTOANTIBODIESPERIODONTITISCARDIAC FUNCTIONBETA 1 ADRENERGIC RECEPTORhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility.Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaHindawi Publishing Corporation2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13307Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina; Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction; Hindawi Publishing Corporation; ISRN Dentistry; 2011; 791393; 9-2011; 1-92090-4371enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/isrn/2011/791393/info:eu-repo/semantics/altIdentifier/doi/10.5402/2011/791393info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:13Zoai:ri.conicet.gov.ar:11336/13307instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:13.649CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
title |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
spellingShingle |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction Segovia, Marcela AUTOANTIBODIES PERIODONTITIS CARDIAC FUNCTION BETA 1 ADRENERGIC RECEPTOR |
title_short |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
title_full |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
title_fullStr |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
title_full_unstemmed |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
title_sort |
Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction |
dc.creator.none.fl_str_mv |
Segovia, Marcela Reina, Silvia Lorena Borda, Enri Santiago Sterin, Leonor Josefina |
author |
Segovia, Marcela |
author_facet |
Segovia, Marcela Reina, Silvia Lorena Borda, Enri Santiago Sterin, Leonor Josefina |
author_role |
author |
author2 |
Reina, Silvia Lorena Borda, Enri Santiago Sterin, Leonor Josefina |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
AUTOANTIBODIES PERIODONTITIS CARDIAC FUNCTION BETA 1 ADRENERGIC RECEPTOR |
topic |
AUTOANTIBODIES PERIODONTITIS CARDIAC FUNCTION BETA 1 ADRENERGIC RECEPTOR |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility. Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina Fil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina |
description |
The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/13307 Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina; Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction; Hindawi Publishing Corporation; ISRN Dentistry; 2011; 791393; 9-2011; 1-9 2090-4371 |
url |
http://hdl.handle.net/11336/13307 |
identifier_str_mv |
Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina; Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction; Hindawi Publishing Corporation; ISRN Dentistry; 2011; 791393; 9-2011; 1-9 2090-4371 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/isrn/2011/791393/ info:eu-repo/semantics/altIdentifier/doi/10.5402/2011/791393 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614442632871936 |
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13.070432 |