Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction

Autores
Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility.
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
AUTOANTIBODIES
PERIODONTITIS
CARDIAC FUNCTION
BETA 1 ADRENERGIC RECEPTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13307
Acceder
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spelling Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac DysfunctionSegovia, MarcelaReina, Silvia LorenaBorda, Enri SantiagoSterin, Leonor JosefinaAUTOANTIBODIESPERIODONTITISCARDIAC FUNCTIONBETA 1 ADRENERGIC RECEPTORhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility.Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaHindawi Publishing Corporation2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13307Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina; Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction; Hindawi Publishing Corporation; ISRN Dentistry; 2011; 791393; 9-2011; 1-92090-4371enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/isrn/2011/791393/info:eu-repo/semantics/altIdentifier/doi/10.5402/2011/791393info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:13:46Zoai:ri.conicet.gov.ar:11336/13307instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:13:46.352CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
title Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
spellingShingle Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
Segovia, Marcela
AUTOANTIBODIES
PERIODONTITIS
CARDIAC FUNCTION
BETA 1 ADRENERGIC RECEPTOR
title_short Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
title_full Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
title_fullStr Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
title_full_unstemmed Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
title_sort Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
dc.creator.none.fl_str_mv Segovia, Marcela
Reina, Silvia Lorena
Borda, Enri Santiago
Sterin, Leonor Josefina
author Segovia, Marcela
author_facet Segovia, Marcela
Reina, Silvia Lorena
Borda, Enri Santiago
Sterin, Leonor Josefina
author_role author
author2 Reina, Silvia Lorena
Borda, Enri Santiago
Sterin, Leonor Josefina
author2_role author
author
author
dc.subject.none.fl_str_mv AUTOANTIBODIES
PERIODONTITIS
CARDIAC FUNCTION
BETA 1 ADRENERGIC RECEPTOR
topic AUTOANTIBODIES
PERIODONTITIS
CARDIAC FUNCTION
BETA 1 ADRENERGIC RECEPTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility.
Fil: Segovia, Marcela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description The presence of serum autoantibodies in periodontitis (P) patients against â(1)-adrenoceptor (â(1)-AR), using cardiac membranes or a synthetic â(1)-AR peptide corresponding to the second extracellular loop of human â(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-â(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-â(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the â(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-â(1)-AR autoantibodies in alteration of myocardial contractility.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13307
Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina; Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction; Hindawi Publishing Corporation; ISRN Dentistry; 2011; 791393; 9-2011; 1-9
2090-4371
url http://hdl.handle.net/11336/13307
identifier_str_mv Segovia, Marcela; Reina, Silvia Lorena; Borda, Enri Santiago; Sterin, Leonor Josefina; Autoantibodies to the beta(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction; Hindawi Publishing Corporation; ISRN Dentistry; 2011; 791393; 9-2011; 1-9
2090-4371
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/isrn/2011/791393/
info:eu-repo/semantics/altIdentifier/doi/10.5402/2011/791393
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782541781008384
score 12.982451

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