Docking applied to the study of inhibitors of c-Met kinase

Autores
Gavernet, Luciana; Palestro, Pablo Hernán; Bruno Blanch, Luis Enrique
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this investigation we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.
Fil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina
Materia
Quinoxalines
Cancer
Docking
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/246370
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Docking applied to the study of inhibitors of c-Met kinaseGavernet, LucianaPalestro, Pablo HernánBruno Blanch, Luis EnriqueQuinoxalinesCancerDockinghttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this investigation we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.Fil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; ArgentinaInternational Scholarly Research Network2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246370Gavernet, Luciana; Palestro, Pablo Hernán; Bruno Blanch, Luis Enrique; Docking applied to the study of inhibitors of c-Met kinase; International Scholarly Research Network; ISRN Physical Chemistry; 2012; 391897; 12-2012; 1-52090-7761CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.5402/2012/391897info:eu-repo/semantics/altIdentifier/doi/10.5402/2012/391897info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:22:07Zoai:ri.conicet.gov.ar:11336/246370instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:22:08.185CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Docking applied to the study of inhibitors of c-Met kinase
title Docking applied to the study of inhibitors of c-Met kinase
spellingShingle Docking applied to the study of inhibitors of c-Met kinase
Gavernet, Luciana
Quinoxalines
Cancer
Docking
title_short Docking applied to the study of inhibitors of c-Met kinase
title_full Docking applied to the study of inhibitors of c-Met kinase
title_fullStr Docking applied to the study of inhibitors of c-Met kinase
title_full_unstemmed Docking applied to the study of inhibitors of c-Met kinase
title_sort Docking applied to the study of inhibitors of c-Met kinase
dc.creator.none.fl_str_mv Gavernet, Luciana
Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
author Gavernet, Luciana
author_facet Gavernet, Luciana
Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
author_role author
author2 Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
author2_role author
author
dc.subject.none.fl_str_mv Quinoxalines
Cancer
Docking
topic Quinoxalines
Cancer
Docking
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this investigation we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.
Fil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina
description Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this investigation we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/246370
Gavernet, Luciana; Palestro, Pablo Hernán; Bruno Blanch, Luis Enrique; Docking applied to the study of inhibitors of c-Met kinase; International Scholarly Research Network; ISRN Physical Chemistry; 2012; 391897; 12-2012; 1-5
2090-7761
CONICET Digital
CONICET
url http://hdl.handle.net/11336/246370
identifier_str_mv Gavernet, Luciana; Palestro, Pablo Hernán; Bruno Blanch, Luis Enrique; Docking applied to the study of inhibitors of c-Met kinase; International Scholarly Research Network; ISRN Physical Chemistry; 2012; 391897; 12-2012; 1-5
2090-7761
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.5402/2012/391897
info:eu-repo/semantics/altIdentifier/doi/10.5402/2012/391897
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Scholarly Research Network
publisher.none.fl_str_mv International Scholarly Research Network
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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