Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Autores
Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; Gomes, Karina S.; Anderzhanova, Elmira; Pöhlmann, Max L.; Chang, Simon; Kolarz, Adam; Vogl, Annette M.; Dine, Julien; Metzger, Michael W.; Schmid, Bianca; Almada, Rafael C.; Ressler, Kerry J.; Wotjak, Carsten T.; Grinevich, Valery; Chen, Alon; Schmidt, Mathias V.; Wurst, Wolfgang; Refojo, Damian; Deussing, Jan M.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
Fil: Dedic, Nina. Max Planck Institute Of Psychiatry; Alemania
Fil: Kühne, Claudia. Max Planck Institute Of Psychiatry; Alemania
Fil: Jakovcevski, Mira. Max Planck Institute Of Psychiatry; Alemania
Fil: Hartmann, Jakob. Max Planck Institute Of Psychiatry; Alemania
Fil: Genewsky, Andreas J.. Max Planck Institut Of Psychiatry; Alemania
Fil: Gomes, Karina S.. Max Planck Institute Of Psychiatry; Alemania
Fil: Anderzhanova, Elmira. Max Planck Institute Of Psychiatry; Alemania
Fil: Pöhlmann, Max L.. Max Planck Institute Of Psychiatry; Alemania
Fil: Chang, Simon. Max Planck Institute Of Psychiatry; Alemania
Fil: Kolarz, Adam. Max Planck Institute Of Psychiatry; Alemania
Fil: Vogl, Annette M.. Max Planck Institute Of Psychiatry; Alemania
Fil: Dine, Julien. Max Planck Institute Of Psychiatry; Alemania
Fil: Metzger, Michael W.. Max Planck Institute of Psychiatry; Armenia
Fil: Schmid, Bianca. Max Planck Institute Of Psychiatry; Alemania
Fil: Almada, Rafael C.. Max Planck Institute Of Psychiatry; Alemania
Fil: Ressler, Kerry J.. Harvard Medical School; Estados Unidos
Fil: Wotjak, Carsten T.. Max Planck Institute Of Psychiatry; Alemania
Fil: Grinevich, Valery. University of Heidelberg; Alemania
Fil: Chen, Alon. Max Planck Institute Of Psychiatry; Alemania
Fil: Schmidt, Mathias V.. Institute Of Developmental Genetics, Helmholtz Zentrum; Alemania
Fil: Wurst, Wolfgang. German Center for Neurodegenerative Diseases; Alemania
Fil: Refojo, Damian. Max Planck Institute Of Psychiatry; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Deussing, Jan M.. Max Planck Institute Of Psychiatry; Alemania
Materia
CRH
CRF
depression
behavior
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125820
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125820
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxietyDedic, NinaKühne, ClaudiaJakovcevski, MiraHartmann, JakobGenewsky, Andreas J.Gomes, Karina S.Anderzhanova, ElmiraPöhlmann, Max L.Chang, SimonKolarz, AdamVogl, Annette M.Dine, JulienMetzger, Michael W.Schmid, BiancaAlmada, Rafael C.Ressler, Kerry J.Wotjak, Carsten T.Grinevich, ValeryChen, AlonSchmidt, Mathias V.Wurst, WolfgangRefojo, DamianDeussing, Jan M.CRHCRFdepressionbehaviorhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.Fil: Dedic, Nina. Max Planck Institute Of Psychiatry; AlemaniaFil: Kühne, Claudia. Max Planck Institute Of Psychiatry; AlemaniaFil: Jakovcevski, Mira. Max Planck Institute Of Psychiatry; AlemaniaFil: Hartmann, Jakob. Max Planck Institute Of Psychiatry; AlemaniaFil: Genewsky, Andreas J.. Max Planck Institut Of Psychiatry; AlemaniaFil: Gomes, Karina S.. Max Planck Institute Of Psychiatry; AlemaniaFil: Anderzhanova, Elmira. Max Planck Institute Of Psychiatry; AlemaniaFil: Pöhlmann, Max L.. Max Planck Institute Of Psychiatry; AlemaniaFil: Chang, Simon. Max Planck Institute Of Psychiatry; AlemaniaFil: Kolarz, Adam. Max Planck Institute Of Psychiatry; AlemaniaFil: Vogl, Annette M.. Max Planck Institute Of Psychiatry; AlemaniaFil: Dine, Julien. Max Planck Institute Of Psychiatry; AlemaniaFil: Metzger, Michael W.. Max Planck Institute of Psychiatry; ArmeniaFil: Schmid, Bianca. Max Planck Institute Of Psychiatry; AlemaniaFil: Almada, Rafael C.. Max Planck Institute Of Psychiatry; AlemaniaFil: Ressler, Kerry J.. Harvard Medical School; Estados UnidosFil: Wotjak, Carsten T.. Max Planck Institute Of Psychiatry; AlemaniaFil: Grinevich, Valery. University of Heidelberg; AlemaniaFil: Chen, Alon. Max Planck Institute Of Psychiatry; AlemaniaFil: Schmidt, Mathias V.. Institute Of Developmental Genetics, Helmholtz Zentrum; AlemaniaFil: Wurst, Wolfgang. German Center for Neurodegenerative Diseases; AlemaniaFil: Refojo, Damian. Max Planck Institute Of Psychiatry; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Deussing, Jan M.. Max Planck Institute Of Psychiatry; AlemaniaNature Publishing Group2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125820Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; et al.; Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety; Nature Publishing Group; Nature Neuroscience.; 21; 6; 5-2018; 803-8071097-6256CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41593-018-0151-zinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41593-018-0151-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:00Zoai:ri.conicet.gov.ar:11336/125820instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:00.36CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
title Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
spellingShingle Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Dedic, Nina
CRH
CRF
depression
behavior
title_short Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
title_full Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
title_fullStr Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
title_full_unstemmed Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
title_sort Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
dc.creator.none.fl_str_mv Dedic, Nina
Kühne, Claudia
Jakovcevski, Mira
Hartmann, Jakob
Genewsky, Andreas J.
Gomes, Karina S.
Anderzhanova, Elmira
Pöhlmann, Max L.
Chang, Simon
Kolarz, Adam
Vogl, Annette M.
Dine, Julien
Metzger, Michael W.
Schmid, Bianca
Almada, Rafael C.
Ressler, Kerry J.
Wotjak, Carsten T.
Grinevich, Valery
Chen, Alon
Schmidt, Mathias V.
Wurst, Wolfgang
Refojo, Damian
Deussing, Jan M.
author Dedic, Nina
author_facet Dedic, Nina
Kühne, Claudia
Jakovcevski, Mira
Hartmann, Jakob
Genewsky, Andreas J.
Gomes, Karina S.
Anderzhanova, Elmira
Pöhlmann, Max L.
Chang, Simon
Kolarz, Adam
Vogl, Annette M.
Dine, Julien
Metzger, Michael W.
Schmid, Bianca
Almada, Rafael C.
Ressler, Kerry J.
Wotjak, Carsten T.
Grinevich, Valery
Chen, Alon
Schmidt, Mathias V.
Wurst, Wolfgang
Refojo, Damian
Deussing, Jan M.
author_role author
author2 Kühne, Claudia
Jakovcevski, Mira
Hartmann, Jakob
Genewsky, Andreas J.
Gomes, Karina S.
Anderzhanova, Elmira
Pöhlmann, Max L.
Chang, Simon
Kolarz, Adam
Vogl, Annette M.
Dine, Julien
Metzger, Michael W.
Schmid, Bianca
Almada, Rafael C.
Ressler, Kerry J.
Wotjak, Carsten T.
Grinevich, Valery
Chen, Alon
Schmidt, Mathias V.
Wurst, Wolfgang
Refojo, Damian
Deussing, Jan M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CRH
CRF
depression
behavior
topic CRH
CRF
depression
behavior
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
Fil: Dedic, Nina. Max Planck Institute Of Psychiatry; Alemania
Fil: Kühne, Claudia. Max Planck Institute Of Psychiatry; Alemania
Fil: Jakovcevski, Mira. Max Planck Institute Of Psychiatry; Alemania
Fil: Hartmann, Jakob. Max Planck Institute Of Psychiatry; Alemania
Fil: Genewsky, Andreas J.. Max Planck Institut Of Psychiatry; Alemania
Fil: Gomes, Karina S.. Max Planck Institute Of Psychiatry; Alemania
Fil: Anderzhanova, Elmira. Max Planck Institute Of Psychiatry; Alemania
Fil: Pöhlmann, Max L.. Max Planck Institute Of Psychiatry; Alemania
Fil: Chang, Simon. Max Planck Institute Of Psychiatry; Alemania
Fil: Kolarz, Adam. Max Planck Institute Of Psychiatry; Alemania
Fil: Vogl, Annette M.. Max Planck Institute Of Psychiatry; Alemania
Fil: Dine, Julien. Max Planck Institute Of Psychiatry; Alemania
Fil: Metzger, Michael W.. Max Planck Institute of Psychiatry; Armenia
Fil: Schmid, Bianca. Max Planck Institute Of Psychiatry; Alemania
Fil: Almada, Rafael C.. Max Planck Institute Of Psychiatry; Alemania
Fil: Ressler, Kerry J.. Harvard Medical School; Estados Unidos
Fil: Wotjak, Carsten T.. Max Planck Institute Of Psychiatry; Alemania
Fil: Grinevich, Valery. University of Heidelberg; Alemania
Fil: Chen, Alon. Max Planck Institute Of Psychiatry; Alemania
Fil: Schmidt, Mathias V.. Institute Of Developmental Genetics, Helmholtz Zentrum; Alemania
Fil: Wurst, Wolfgang. German Center for Neurodegenerative Diseases; Alemania
Fil: Refojo, Damian. Max Planck Institute Of Psychiatry; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Deussing, Jan M.. Max Planck Institute Of Psychiatry; Alemania
description The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125820
Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; et al.; Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety; Nature Publishing Group; Nature Neuroscience.; 21; 6; 5-2018; 803-807
1097-6256
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125820
identifier_str_mv Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; et al.; Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety; Nature Publishing Group; Nature Neuroscience.; 21; 6; 5-2018; 803-807
1097-6256
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41593-018-0151-z
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41593-018-0151-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613903212871680
score 13.070432

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