Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice

Autores
Blake, Mariano Guillermo; Boccia, Mariano Martín; Carcaboso, Ángel M.; Chiappetta, Diego Andrés; Höcht, Christian; Krawczyk, Maria del Carmen; Sosnik, Alejandro Dario; Baratti, Carlos Maria
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7 days impairs memory. This is in accordance with the observation that long-term clinical treatment with GBP may be associated with adverse cognitive side effects. In the present work we used a GBP-loaded poly(ε-caprolactone) implant, allowing controlled release of the drug and maintenance of constant plasma levels over 1 week. When GBP-loaded implants were inserted subcutaneously into mice, immediately after training in the IA task, memory consolidation was enhanced. Moreover, GBP released from implants had an anticonvulsant action against pentylenetetrazole-induced seizures. These results suggest that maintenance of stable GBP plasma levels could protect against seizures without causing memory impairment. Hence, the adverse cognitive effects might be avoided by stabilizing plasma levels of the drug.
Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Carcaboso, Ángel M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Baratti, Carlos Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Materia
ACETYLCHOLINE
ANTIEPILEPTIC DRUGS
DRUG DELIVERY SYSTEMS
EPILEPSY
GABAPENTIN
INHIBITORY AVOIDANCE
KINDLING
MEMORY
MICE
PENTYLENETETRAZOLE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112984
Acceder
id CONICETDig_03aa03bb877f780913fedad15ec983f9
oai_identifier_str oai:ri.conicet.gov.ar:11336/112984
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in miceBlake, Mariano GuillermoBoccia, Mariano MartínCarcaboso, Ángel M.Chiappetta, Diego AndrésHöcht, ChristianKrawczyk, Maria del CarmenSosnik, Alejandro DarioBaratti, Carlos MariaACETYLCHOLINEANTIEPILEPTIC DRUGSDRUG DELIVERY SYSTEMSEPILEPSYGABAPENTININHIBITORY AVOIDANCEKINDLINGMEMORYMICEPENTYLENETETRAZOLEhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7 days impairs memory. This is in accordance with the observation that long-term clinical treatment with GBP may be associated with adverse cognitive side effects. In the present work we used a GBP-loaded poly(ε-caprolactone) implant, allowing controlled release of the drug and maintenance of constant plasma levels over 1 week. When GBP-loaded implants were inserted subcutaneously into mice, immediately after training in the IA task, memory consolidation was enhanced. Moreover, GBP released from implants had an anticonvulsant action against pentylenetetrazole-induced seizures. These results suggest that maintenance of stable GBP plasma levels could protect against seizures without causing memory impairment. Hence, the adverse cognitive effects might be avoided by stabilizing plasma levels of the drug.Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Carcaboso, Ángel M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Baratti, Carlos Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaAcademic Press Inc Elsevier Science2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112984Blake, Mariano Guillermo; Boccia, Mariano Martín; Carcaboso, Ángel M.; Chiappetta, Diego Andrés; Höcht, Christian; et al.; Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice; Academic Press Inc Elsevier Science; Epilepsy & Behavior (print); 17; 2; 2-2010; 157-1641525-5050CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1525505009006817info:eu-repo/semantics/altIdentifier/doi/10.1016/j.yebeh.2009.12.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:28Zoai:ri.conicet.gov.ar:11336/112984instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:28.199CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
title Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
spellingShingle Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
Blake, Mariano Guillermo
ACETYLCHOLINE
ANTIEPILEPTIC DRUGS
DRUG DELIVERY SYSTEMS
EPILEPSY
GABAPENTIN
INHIBITORY AVOIDANCE
KINDLING
MEMORY
MICE
PENTYLENETETRAZOLE
title_short Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
title_full Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
title_fullStr Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
title_full_unstemmed Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
title_sort Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
dc.creator.none.fl_str_mv Blake, Mariano Guillermo
Boccia, Mariano Martín
Carcaboso, Ángel M.
Chiappetta, Diego Andrés
Höcht, Christian
Krawczyk, Maria del Carmen
Sosnik, Alejandro Dario
Baratti, Carlos Maria
author Blake, Mariano Guillermo
author_facet Blake, Mariano Guillermo
Boccia, Mariano Martín
Carcaboso, Ángel M.
Chiappetta, Diego Andrés
Höcht, Christian
Krawczyk, Maria del Carmen
Sosnik, Alejandro Dario
Baratti, Carlos Maria
author_role author
author2 Boccia, Mariano Martín
Carcaboso, Ángel M.
Chiappetta, Diego Andrés
Höcht, Christian
Krawczyk, Maria del Carmen
Sosnik, Alejandro Dario
Baratti, Carlos Maria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACETYLCHOLINE
ANTIEPILEPTIC DRUGS
DRUG DELIVERY SYSTEMS
EPILEPSY
GABAPENTIN
INHIBITORY AVOIDANCE
KINDLING
MEMORY
MICE
PENTYLENETETRAZOLE
topic ACETYLCHOLINE
ANTIEPILEPTIC DRUGS
DRUG DELIVERY SYSTEMS
EPILEPSY
GABAPENTIN
INHIBITORY AVOIDANCE
KINDLING
MEMORY
MICE
PENTYLENETETRAZOLE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7 days impairs memory. This is in accordance with the observation that long-term clinical treatment with GBP may be associated with adverse cognitive side effects. In the present work we used a GBP-loaded poly(ε-caprolactone) implant, allowing controlled release of the drug and maintenance of constant plasma levels over 1 week. When GBP-loaded implants were inserted subcutaneously into mice, immediately after training in the IA task, memory consolidation was enhanced. Moreover, GBP released from implants had an anticonvulsant action against pentylenetetrazole-induced seizures. These results suggest that maintenance of stable GBP plasma levels could protect against seizures without causing memory impairment. Hence, the adverse cognitive effects might be avoided by stabilizing plasma levels of the drug.
Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Carcaboso, Ángel M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Baratti, Carlos Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
description We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7 days impairs memory. This is in accordance with the observation that long-term clinical treatment with GBP may be associated with adverse cognitive side effects. In the present work we used a GBP-loaded poly(ε-caprolactone) implant, allowing controlled release of the drug and maintenance of constant plasma levels over 1 week. When GBP-loaded implants were inserted subcutaneously into mice, immediately after training in the IA task, memory consolidation was enhanced. Moreover, GBP released from implants had an anticonvulsant action against pentylenetetrazole-induced seizures. These results suggest that maintenance of stable GBP plasma levels could protect against seizures without causing memory impairment. Hence, the adverse cognitive effects might be avoided by stabilizing plasma levels of the drug.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112984
Blake, Mariano Guillermo; Boccia, Mariano Martín; Carcaboso, Ángel M.; Chiappetta, Diego Andrés; Höcht, Christian; et al.; Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice; Academic Press Inc Elsevier Science; Epilepsy & Behavior (print); 17; 2; 2-2010; 157-164
1525-5050
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112984
identifier_str_mv Blake, Mariano Guillermo; Boccia, Mariano Martín; Carcaboso, Ángel M.; Chiappetta, Diego Andrés; Höcht, Christian; et al.; Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice; Academic Press Inc Elsevier Science; Epilepsy & Behavior (print); 17; 2; 2-2010; 157-164
1525-5050
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1525505009006817
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.yebeh.2009.12.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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