Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms

Autores
Blake, Mariano Guillermo; Krawczyk, Maria del Carmen; Baratti, Carlos Maria; Boccia, Mariano Martin
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, extinction, retrieval and expression. Experiments from our laboratory are mainly focused on elucidating the mechanisms by which acetylcholine modulates memory processes. Blockade of hippocampal alpha-7-nicotinic receptors (α7-nAChRs) with the antagonist methyllycaconitine impairs memory reconsolidation. However, the administration of a α7-nAChR agonist (choline) produce a paradoxical modulation, causing memory enhancement in mice trained with a weak footshock, but memory impairment in animals trained with a strong footshock. All these effects are long-lasting, and depend on the age of the memory trace. This review summarizes and discusses some of our recent findings, particularly regarding the involvement of α7-nAChRs on memory reconsolidation.
Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Baratti, Carlos Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Boccia, Mariano Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Memory
Memory Consolidation
Memory Reconsolidation
Mice
Inhibitory Avoidance
Acetylcholine
Alpha 7 Nicotinic Receptors
Choline
Methyllicaconitine
Hippocampus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15738
Acceder
id CONICETDig_02b5fc9561a4f95da5ff786095d7df10
oai_identifier_str oai:ri.conicet.gov.ar:11336/15738
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanismsBlake, Mariano GuillermoKrawczyk, Maria del CarmenBaratti, Carlos MariaBoccia, Mariano MartinMemoryMemory ConsolidationMemory ReconsolidationMiceInhibitory AvoidanceAcetylcholineAlpha 7 Nicotinic ReceptorsCholineMethyllicaconitineHippocampushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, extinction, retrieval and expression. Experiments from our laboratory are mainly focused on elucidating the mechanisms by which acetylcholine modulates memory processes. Blockade of hippocampal alpha-7-nicotinic receptors (α7-nAChRs) with the antagonist methyllycaconitine impairs memory reconsolidation. However, the administration of a α7-nAChR agonist (choline) produce a paradoxical modulation, causing memory enhancement in mice trained with a weak footshock, but memory impairment in animals trained with a strong footshock. All these effects are long-lasting, and depend on the age of the memory trace. This review summarizes and discusses some of our recent findings, particularly regarding the involvement of α7-nAChRs on memory reconsolidation.Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Baratti, Carlos Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Boccia, Mariano Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15738Blake, Mariano Guillermo; Krawczyk, Maria del Carmen; Baratti, Carlos Maria; Boccia, Mariano Martin; Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms; Elsevier; Journal of Physiology; 108; 4-6; 12-2014; 286-2910928-4257enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0928425714000163info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphysparis.2014.04.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:06:18Zoai:ri.conicet.gov.ar:11336/15738instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:06:18.69CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
title Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
spellingShingle Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
Blake, Mariano Guillermo
Memory
Memory Consolidation
Memory Reconsolidation
Mice
Inhibitory Avoidance
Acetylcholine
Alpha 7 Nicotinic Receptors
Choline
Methyllicaconitine
Hippocampus
title_short Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
title_full Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
title_fullStr Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
title_full_unstemmed Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
title_sort Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
dc.creator.none.fl_str_mv Blake, Mariano Guillermo
Krawczyk, Maria del Carmen
Baratti, Carlos Maria
Boccia, Mariano Martin
author Blake, Mariano Guillermo
author_facet Blake, Mariano Guillermo
Krawczyk, Maria del Carmen
Baratti, Carlos Maria
Boccia, Mariano Martin
author_role author
author2 Krawczyk, Maria del Carmen
Baratti, Carlos Maria
Boccia, Mariano Martin
author2_role author
author
author
dc.subject.none.fl_str_mv Memory
Memory Consolidation
Memory Reconsolidation
Mice
Inhibitory Avoidance
Acetylcholine
Alpha 7 Nicotinic Receptors
Choline
Methyllicaconitine
Hippocampus
topic Memory
Memory Consolidation
Memory Reconsolidation
Mice
Inhibitory Avoidance
Acetylcholine
Alpha 7 Nicotinic Receptors
Choline
Methyllicaconitine
Hippocampus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, extinction, retrieval and expression. Experiments from our laboratory are mainly focused on elucidating the mechanisms by which acetylcholine modulates memory processes. Blockade of hippocampal alpha-7-nicotinic receptors (α7-nAChRs) with the antagonist methyllycaconitine impairs memory reconsolidation. However, the administration of a α7-nAChR agonist (choline) produce a paradoxical modulation, causing memory enhancement in mice trained with a weak footshock, but memory impairment in animals trained with a strong footshock. All these effects are long-lasting, and depend on the age of the memory trace. This review summarizes and discusses some of our recent findings, particularly regarding the involvement of α7-nAChRs on memory reconsolidation.
Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Baratti, Carlos Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Boccia, Mariano Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, extinction, retrieval and expression. Experiments from our laboratory are mainly focused on elucidating the mechanisms by which acetylcholine modulates memory processes. Blockade of hippocampal alpha-7-nicotinic receptors (α7-nAChRs) with the antagonist methyllycaconitine impairs memory reconsolidation. However, the administration of a α7-nAChR agonist (choline) produce a paradoxical modulation, causing memory enhancement in mice trained with a weak footshock, but memory impairment in animals trained with a strong footshock. All these effects are long-lasting, and depend on the age of the memory trace. This review summarizes and discusses some of our recent findings, particularly regarding the involvement of α7-nAChRs on memory reconsolidation.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15738
Blake, Mariano Guillermo; Krawczyk, Maria del Carmen; Baratti, Carlos Maria; Boccia, Mariano Martin; Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms; Elsevier; Journal of Physiology; 108; 4-6; 12-2014; 286-291
0928-4257
url http://hdl.handle.net/11336/15738
identifier_str_mv Blake, Mariano Guillermo; Krawczyk, Maria del Carmen; Baratti, Carlos Maria; Boccia, Mariano Martin; Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms; Elsevier; Journal of Physiology; 108; 4-6; 12-2014; 286-291
0928-4257
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0928425714000163
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphysparis.2014.04.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980257492107264
score 12.993085

Publicaciones similares