Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy

Autores
Tomson, Torbjörn; Battino, Dina; Bromley, Rebecca; Kochen, Sara Silvia; Meador, Kimford; Pennell, Page; Thomas, Sanjeev V.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The risks associated with use of antiepileptic drugs during pregnancy are a major concern for all women with epilepsy with childbearing potential. These risks have to be balanced against foetal and maternal risks associated with uncontrolled seizures. This report from the International League Against Epilepsy Task Force on Women and Pregnancy aims to provide a summary of relevant data on these risks as a basis for expert opinion recommendations for the management of epilepsy in pregnancy. The report reviews data on maternal and foetal risks associated with seizures as well as teratogenic risks associated with antiepileptic drug exposure, including effects on intrauterine growth, major congenital malformations, and developmental and behavioural outcomes. The impact of pregnancy on seizure control and on the pharmacokinetics of antiepileptic drugs are also discussed. This information is used to discuss how treatment may be optimized before conception and further managed during pregnancy.
Fil: Tomson, Torbjörn. Karolinska University Hospital; Suecia
Fil: Battino, Dina. No especifíca;
Fil: Bromley, Rebecca. University of Manchester; Reino Unido
Fil: Kochen, Sara Silvia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Meador, Kimford. University of Stanford; Estados Unidos
Fil: Pennell, Page. Brigham And Women's Hospital; Estados Unidos
Fil: Thomas, Sanjeev V.. Sree Chitra Tirunal Institute For Medical Sciences And Technology; India
Materia
ANTIEPILEPTIC DRUGS
EPILEPSY
FOETAL RISKS
PREGNANCY
TERATOGENESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/119061
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/119061
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and PregnancyTomson, TorbjörnBattino, DinaBromley, RebeccaKochen, Sara SilviaMeador, KimfordPennell, PageThomas, Sanjeev V.ANTIEPILEPTIC DRUGSEPILEPSYFOETAL RISKSPREGNANCYTERATOGENESIShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The risks associated with use of antiepileptic drugs during pregnancy are a major concern for all women with epilepsy with childbearing potential. These risks have to be balanced against foetal and maternal risks associated with uncontrolled seizures. This report from the International League Against Epilepsy Task Force on Women and Pregnancy aims to provide a summary of relevant data on these risks as a basis for expert opinion recommendations for the management of epilepsy in pregnancy. The report reviews data on maternal and foetal risks associated with seizures as well as teratogenic risks associated with antiepileptic drug exposure, including effects on intrauterine growth, major congenital malformations, and developmental and behavioural outcomes. The impact of pregnancy on seizure control and on the pharmacokinetics of antiepileptic drugs are also discussed. This information is used to discuss how treatment may be optimized before conception and further managed during pregnancy.Fil: Tomson, Torbjörn. Karolinska University Hospital; SueciaFil: Battino, Dina. No especifíca;Fil: Bromley, Rebecca. University of Manchester; Reino UnidoFil: Kochen, Sara Silvia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Meador, Kimford. University of Stanford; Estados UnidosFil: Pennell, Page. Brigham And Women's Hospital; Estados UnidosFil: Thomas, Sanjeev V.. Sree Chitra Tirunal Institute For Medical Sciences And Technology; IndiaInternational League Against Epilepsy2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/119061Tomson, Torbjörn; Battino, Dina; Bromley, Rebecca; Kochen, Sara Silvia; Meador, Kimford; et al.; Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy; International League Against Epilepsy; Epileptic Disorders; 21; 6; 12-2019; 497-5171950-6945CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jle.com/fr/revues/epd/e-docs/management_of_epilepsy_in_pregnancy_a_report_from_the_international_league_against_epilepsy_task_force_on_women_and_pregnancy_315740/article.phtmlinfo:eu-repo/semantics/altIdentifier/doi/10.1684/epd.2019.1105info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:41Zoai:ri.conicet.gov.ar:11336/119061instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:41.891CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
title Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
spellingShingle Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
Tomson, Torbjörn
ANTIEPILEPTIC DRUGS
EPILEPSY
FOETAL RISKS
PREGNANCY
TERATOGENESIS
title_short Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
title_full Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
title_fullStr Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
title_full_unstemmed Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
title_sort Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy
dc.creator.none.fl_str_mv Tomson, Torbjörn
Battino, Dina
Bromley, Rebecca
Kochen, Sara Silvia
Meador, Kimford
Pennell, Page
Thomas, Sanjeev V.
author Tomson, Torbjörn
author_facet Tomson, Torbjörn
Battino, Dina
Bromley, Rebecca
Kochen, Sara Silvia
Meador, Kimford
Pennell, Page
Thomas, Sanjeev V.
author_role author
author2 Battino, Dina
Bromley, Rebecca
Kochen, Sara Silvia
Meador, Kimford
Pennell, Page
Thomas, Sanjeev V.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIEPILEPTIC DRUGS
EPILEPSY
FOETAL RISKS
PREGNANCY
TERATOGENESIS
topic ANTIEPILEPTIC DRUGS
EPILEPSY
FOETAL RISKS
PREGNANCY
TERATOGENESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The risks associated with use of antiepileptic drugs during pregnancy are a major concern for all women with epilepsy with childbearing potential. These risks have to be balanced against foetal and maternal risks associated with uncontrolled seizures. This report from the International League Against Epilepsy Task Force on Women and Pregnancy aims to provide a summary of relevant data on these risks as a basis for expert opinion recommendations for the management of epilepsy in pregnancy. The report reviews data on maternal and foetal risks associated with seizures as well as teratogenic risks associated with antiepileptic drug exposure, including effects on intrauterine growth, major congenital malformations, and developmental and behavioural outcomes. The impact of pregnancy on seizure control and on the pharmacokinetics of antiepileptic drugs are also discussed. This information is used to discuss how treatment may be optimized before conception and further managed during pregnancy.
Fil: Tomson, Torbjörn. Karolinska University Hospital; Suecia
Fil: Battino, Dina. No especifíca;
Fil: Bromley, Rebecca. University of Manchester; Reino Unido
Fil: Kochen, Sara Silvia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Meador, Kimford. University of Stanford; Estados Unidos
Fil: Pennell, Page. Brigham And Women's Hospital; Estados Unidos
Fil: Thomas, Sanjeev V.. Sree Chitra Tirunal Institute For Medical Sciences And Technology; India
description The risks associated with use of antiepileptic drugs during pregnancy are a major concern for all women with epilepsy with childbearing potential. These risks have to be balanced against foetal and maternal risks associated with uncontrolled seizures. This report from the International League Against Epilepsy Task Force on Women and Pregnancy aims to provide a summary of relevant data on these risks as a basis for expert opinion recommendations for the management of epilepsy in pregnancy. The report reviews data on maternal and foetal risks associated with seizures as well as teratogenic risks associated with antiepileptic drug exposure, including effects on intrauterine growth, major congenital malformations, and developmental and behavioural outcomes. The impact of pregnancy on seizure control and on the pharmacokinetics of antiepileptic drugs are also discussed. This information is used to discuss how treatment may be optimized before conception and further managed during pregnancy.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/119061
Tomson, Torbjörn; Battino, Dina; Bromley, Rebecca; Kochen, Sara Silvia; Meador, Kimford; et al.; Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy; International League Against Epilepsy; Epileptic Disorders; 21; 6; 12-2019; 497-517
1950-6945
CONICET Digital
CONICET
url http://hdl.handle.net/11336/119061
identifier_str_mv Tomson, Torbjörn; Battino, Dina; Bromley, Rebecca; Kochen, Sara Silvia; Meador, Kimford; et al.; Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy; International League Against Epilepsy; Epileptic Disorders; 21; 6; 12-2019; 497-517
1950-6945
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.jle.com/fr/revues/epd/e-docs/management_of_epilepsy_in_pregnancy_a_report_from_the_international_league_against_epilepsy_task_force_on_women_and_pregnancy_315740/article.phtml
info:eu-repo/semantics/altIdentifier/doi/10.1684/epd.2019.1105
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv International League Against Epilepsy
publisher.none.fl_str_mv International League Against Epilepsy
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981076086030336
score 12.48226

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