Central nervous system commitment in Chagas disease
- Autores
- Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.
Fil: Useche, Yerly. Fundación Oswaldo Cruz; Brasil
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: de Meis, Juliana. Fundación Oswaldo Cruz; Brasil
Fil: Bonomo, Adriana. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil - Materia
-
BRAIN INFLAMMATION
CENTRAL NERVOUS SYSTEM
CHAGAS DISEASE
ENCEPHALITIS
NEUROIMMUNE INTERACTIONS
ORAL TRYPANOSOMA CRUZI TRANSMISSION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/211532
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Central nervous system commitment in Chagas diseaseUseche, YerlyPerez, Ana Rosade Meis, JulianaBonomo, AdrianaSavino, WilsonBRAIN INFLAMMATIONCENTRAL NERVOUS SYSTEMCHAGAS DISEASEENCEPHALITISNEUROIMMUNE INTERACTIONSORAL TRYPANOSOMA CRUZI TRANSMISSIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.Fil: Useche, Yerly. Fundación Oswaldo Cruz; BrasilFil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: de Meis, Juliana. Fundación Oswaldo Cruz; BrasilFil: Bonomo, Adriana. Fundación Oswaldo Cruz; BrasilFil: Savino, Wilson. Fundación Oswaldo Cruz; BrasilFrontiers Media2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211532Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson; Central nervous system commitment in Chagas disease; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-91664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2022.975106/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.975106info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:41Zoai:ri.conicet.gov.ar:11336/211532instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:41.324CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Central nervous system commitment in Chagas disease |
title |
Central nervous system commitment in Chagas disease |
spellingShingle |
Central nervous system commitment in Chagas disease Useche, Yerly BRAIN INFLAMMATION CENTRAL NERVOUS SYSTEM CHAGAS DISEASE ENCEPHALITIS NEUROIMMUNE INTERACTIONS ORAL TRYPANOSOMA CRUZI TRANSMISSION |
title_short |
Central nervous system commitment in Chagas disease |
title_full |
Central nervous system commitment in Chagas disease |
title_fullStr |
Central nervous system commitment in Chagas disease |
title_full_unstemmed |
Central nervous system commitment in Chagas disease |
title_sort |
Central nervous system commitment in Chagas disease |
dc.creator.none.fl_str_mv |
Useche, Yerly Perez, Ana Rosa de Meis, Juliana Bonomo, Adriana Savino, Wilson |
author |
Useche, Yerly |
author_facet |
Useche, Yerly Perez, Ana Rosa de Meis, Juliana Bonomo, Adriana Savino, Wilson |
author_role |
author |
author2 |
Perez, Ana Rosa de Meis, Juliana Bonomo, Adriana Savino, Wilson |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
BRAIN INFLAMMATION CENTRAL NERVOUS SYSTEM CHAGAS DISEASE ENCEPHALITIS NEUROIMMUNE INTERACTIONS ORAL TRYPANOSOMA CRUZI TRANSMISSION |
topic |
BRAIN INFLAMMATION CENTRAL NERVOUS SYSTEM CHAGAS DISEASE ENCEPHALITIS NEUROIMMUNE INTERACTIONS ORAL TRYPANOSOMA CRUZI TRANSMISSION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil. Fil: Useche, Yerly. Fundación Oswaldo Cruz; Brasil Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina Fil: de Meis, Juliana. Fundación Oswaldo Cruz; Brasil Fil: Bonomo, Adriana. Fundación Oswaldo Cruz; Brasil Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil |
description |
The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/211532 Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson; Central nervous system commitment in Chagas disease; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-9 1664-3224 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/211532 |
identifier_str_mv |
Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson; Central nervous system commitment in Chagas disease; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-9 1664-3224 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2022.975106/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.975106 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |