Central nervous system commitment in Chagas disease

Autores
Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.
Fil: Useche, Yerly. Fundación Oswaldo Cruz; Brasil
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: de Meis, Juliana. Fundación Oswaldo Cruz; Brasil
Fil: Bonomo, Adriana. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil
Materia
BRAIN INFLAMMATION
CENTRAL NERVOUS SYSTEM
CHAGAS DISEASE
ENCEPHALITIS
NEUROIMMUNE INTERACTIONS
ORAL TRYPANOSOMA CRUZI TRANSMISSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211532

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spelling Central nervous system commitment in Chagas diseaseUseche, YerlyPerez, Ana Rosade Meis, JulianaBonomo, AdrianaSavino, WilsonBRAIN INFLAMMATIONCENTRAL NERVOUS SYSTEMCHAGAS DISEASEENCEPHALITISNEUROIMMUNE INTERACTIONSORAL TRYPANOSOMA CRUZI TRANSMISSIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.Fil: Useche, Yerly. Fundación Oswaldo Cruz; BrasilFil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: de Meis, Juliana. Fundación Oswaldo Cruz; BrasilFil: Bonomo, Adriana. Fundación Oswaldo Cruz; BrasilFil: Savino, Wilson. Fundación Oswaldo Cruz; BrasilFrontiers Media2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211532Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson; Central nervous system commitment in Chagas disease; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-91664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2022.975106/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.975106info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:41Zoai:ri.conicet.gov.ar:11336/211532instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:41.324CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Central nervous system commitment in Chagas disease
title Central nervous system commitment in Chagas disease
spellingShingle Central nervous system commitment in Chagas disease
Useche, Yerly
BRAIN INFLAMMATION
CENTRAL NERVOUS SYSTEM
CHAGAS DISEASE
ENCEPHALITIS
NEUROIMMUNE INTERACTIONS
ORAL TRYPANOSOMA CRUZI TRANSMISSION
title_short Central nervous system commitment in Chagas disease
title_full Central nervous system commitment in Chagas disease
title_fullStr Central nervous system commitment in Chagas disease
title_full_unstemmed Central nervous system commitment in Chagas disease
title_sort Central nervous system commitment in Chagas disease
dc.creator.none.fl_str_mv Useche, Yerly
Perez, Ana Rosa
de Meis, Juliana
Bonomo, Adriana
Savino, Wilson
author Useche, Yerly
author_facet Useche, Yerly
Perez, Ana Rosa
de Meis, Juliana
Bonomo, Adriana
Savino, Wilson
author_role author
author2 Perez, Ana Rosa
de Meis, Juliana
Bonomo, Adriana
Savino, Wilson
author2_role author
author
author
author
dc.subject.none.fl_str_mv BRAIN INFLAMMATION
CENTRAL NERVOUS SYSTEM
CHAGAS DISEASE
ENCEPHALITIS
NEUROIMMUNE INTERACTIONS
ORAL TRYPANOSOMA CRUZI TRANSMISSION
topic BRAIN INFLAMMATION
CENTRAL NERVOUS SYSTEM
CHAGAS DISEASE
ENCEPHALITIS
NEUROIMMUNE INTERACTIONS
ORAL TRYPANOSOMA CRUZI TRANSMISSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.
Fil: Useche, Yerly. Fundación Oswaldo Cruz; Brasil
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: de Meis, Juliana. Fundación Oswaldo Cruz; Brasil
Fil: Bonomo, Adriana. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil
description The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211532
Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson; Central nervous system commitment in Chagas disease; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-9
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211532
identifier_str_mv Useche, Yerly; Perez, Ana Rosa; de Meis, Juliana; Bonomo, Adriana; Savino, Wilson; Central nervous system commitment in Chagas disease; Frontiers Media; Frontiers in Immunology; 13; 10-2022; 1-9
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.975106
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
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