First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up

Autores
Blanchet, Denis; Brenière, Simone Frédérique; Schijman, Alejandro Gabriel; Bisio, Margarita María Catalina; Simon, Stéphane; Veron, Vincent; Mayence, Claire; Demar Pierre, Magalie; Djossou, Félix; Aznar, Christine
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The outbreak of acute Chagas disease due to oral transmission of the parasite is a well-known phenomenon mainly occurring in the Amazon. Such an event is described here for the first time in French Guiana. Eight patients of the same family, presenting epidemiological and clinical histories compatible with recent Trypanosoma cruzi infection of Chagas disease due to the ingestion of palm Oenocarpus bacaba juice were, rather late after the putative date of infection, underwent four parasitological and two serological specific tests for confirmation of the diagnosis. Real-time PCR results were positive for all the patients; strains were isolated by hemoculture from four patients, PCR identification of TcI DTU was made for six patients, while parasites were not detected in any of the patients by direct microscopic examination. The results of two serologic tests were positive. All patients were treated with benznidazole, and two patients were additionally given nifurtimox. A 6-year follow-up was possible for six patients. Real-time PCR was negative for these patients after 1 year, while the antibody rates decreased slowly and serology results were negative only after several years (1–5 years). Our findings confirm the occurrence of an outbreak of Chagas infection in members of the same family, with the oral mode of infection being the most likely hypothesis to explain this group of cases. Our results show the successful treatment of patients infected by TcI and the usefulness of real-time PCR for the emergency diagnosis of recent Chagas disease cases and in posttreatment follow-up.
Fil: Blanchet, Denis. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Brenière, Simone Frédérique. Institut de Recherche pour le Développement, Interactions hôtes-vecteurs-parasites dans les infections par trypanosomatidae; Francia
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Bisio, Margarita María Catalina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "R. Gutierrez". Servicio de Parasitología y Chagas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Simon, Stéphane. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Veron, Vincent. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Mayence, Claire. Centre Hospitalier de l’Ouest Guyanais. Service d’accueil des urgences; Guayana Francesa
Fil: Demar Pierre, Magalie. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Djossou, Félix. Centre Hospitalier Andrée Rosemon. Service de maladie infectieuse et tropicale; Guayana Francesa
Fil: Aznar, Christine. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Materia
Chagas Disease
Genotyping
Trypanosoma Cruzi
Oral Transmission
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3945
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/3945
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-upBlanchet, DenisBrenière, Simone FrédériqueSchijman, Alejandro GabrielBisio, Margarita María CatalinaSimon, StéphaneVeron, VincentMayence, ClaireDemar Pierre, MagalieDjossou, FélixAznar, ChristineChagas DiseaseGenotypingTrypanosoma CruziOral Transmissionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The outbreak of acute Chagas disease due to oral transmission of the parasite is a well-known phenomenon mainly occurring in the Amazon. Such an event is described here for the first time in French Guiana. Eight patients of the same family, presenting epidemiological and clinical histories compatible with recent Trypanosoma cruzi infection of Chagas disease due to the ingestion of palm Oenocarpus bacaba juice were, rather late after the putative date of infection, underwent four parasitological and two serological specific tests for confirmation of the diagnosis. Real-time PCR results were positive for all the patients; strains were isolated by hemoculture from four patients, PCR identification of TcI DTU was made for six patients, while parasites were not detected in any of the patients by direct microscopic examination. The results of two serologic tests were positive. All patients were treated with benznidazole, and two patients were additionally given nifurtimox. A 6-year follow-up was possible for six patients. Real-time PCR was negative for these patients after 1 year, while the antibody rates decreased slowly and serology results were negative only after several years (1–5 years). Our findings confirm the occurrence of an outbreak of Chagas infection in members of the same family, with the oral mode of infection being the most likely hypothesis to explain this group of cases. Our results show the successful treatment of patients infected by TcI and the usefulness of real-time PCR for the emergency diagnosis of recent Chagas disease cases and in posttreatment follow-up.Fil: Blanchet, Denis. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana FrancesaFil: Brenière, Simone Frédérique. Institut de Recherche pour le Développement, Interactions hôtes-vecteurs-parasites dans les infections par trypanosomatidae; FranciaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Bisio, Margarita María Catalina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "R. Gutierrez". Servicio de Parasitología y Chagas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Simon, Stéphane. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana FrancesaFil: Veron, Vincent. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana FrancesaFil: Mayence, Claire. Centre Hospitalier de l’Ouest Guyanais. Service d’accueil des urgences; Guayana FrancesaFil: Demar Pierre, Magalie. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana FrancesaFil: Djossou, Félix. Centre Hospitalier Andrée Rosemon. Service de maladie infectieuse et tropicale; Guayana FrancesaFil: Aznar, Christine. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana FrancesaElsevier2014-10-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3945Blanchet, Denis; Brenière, Simone Frédérique; Schijman, Alejandro Gabriel; Bisio, Margarita María Catalina; Simon, Stéphane; et al.; First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up; Elsevier; Infection, Genetics and Evolution; 28; 14-10-2014; 245-2501567-1348enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S156713481400375Xinfo:eu-repo/semantics/altIdentifier/issn/1567-1348info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2014.10.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:15Zoai:ri.conicet.gov.ar:11336/3945instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:15.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
title First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
spellingShingle First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
Blanchet, Denis
Chagas Disease
Genotyping
Trypanosoma Cruzi
Oral Transmission
title_short First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
title_full First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
title_fullStr First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
title_full_unstemmed First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
title_sort First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up
dc.creator.none.fl_str_mv Blanchet, Denis
Brenière, Simone Frédérique
Schijman, Alejandro Gabriel
Bisio, Margarita María Catalina
Simon, Stéphane
Veron, Vincent
Mayence, Claire
Demar Pierre, Magalie
Djossou, Félix
Aznar, Christine
author Blanchet, Denis
author_facet Blanchet, Denis
Brenière, Simone Frédérique
Schijman, Alejandro Gabriel
Bisio, Margarita María Catalina
Simon, Stéphane
Veron, Vincent
Mayence, Claire
Demar Pierre, Magalie
Djossou, Félix
Aznar, Christine
author_role author
author2 Brenière, Simone Frédérique
Schijman, Alejandro Gabriel
Bisio, Margarita María Catalina
Simon, Stéphane
Veron, Vincent
Mayence, Claire
Demar Pierre, Magalie
Djossou, Félix
Aznar, Christine
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas Disease
Genotyping
Trypanosoma Cruzi
Oral Transmission
topic Chagas Disease
Genotyping
Trypanosoma Cruzi
Oral Transmission
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The outbreak of acute Chagas disease due to oral transmission of the parasite is a well-known phenomenon mainly occurring in the Amazon. Such an event is described here for the first time in French Guiana. Eight patients of the same family, presenting epidemiological and clinical histories compatible with recent Trypanosoma cruzi infection of Chagas disease due to the ingestion of palm Oenocarpus bacaba juice were, rather late after the putative date of infection, underwent four parasitological and two serological specific tests for confirmation of the diagnosis. Real-time PCR results were positive for all the patients; strains were isolated by hemoculture from four patients, PCR identification of TcI DTU was made for six patients, while parasites were not detected in any of the patients by direct microscopic examination. The results of two serologic tests were positive. All patients were treated with benznidazole, and two patients were additionally given nifurtimox. A 6-year follow-up was possible for six patients. Real-time PCR was negative for these patients after 1 year, while the antibody rates decreased slowly and serology results were negative only after several years (1–5 years). Our findings confirm the occurrence of an outbreak of Chagas infection in members of the same family, with the oral mode of infection being the most likely hypothesis to explain this group of cases. Our results show the successful treatment of patients infected by TcI and the usefulness of real-time PCR for the emergency diagnosis of recent Chagas disease cases and in posttreatment follow-up.
Fil: Blanchet, Denis. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Brenière, Simone Frédérique. Institut de Recherche pour le Développement, Interactions hôtes-vecteurs-parasites dans les infections par trypanosomatidae; Francia
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Bisio, Margarita María Catalina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "R. Gutierrez". Servicio de Parasitología y Chagas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Simon, Stéphane. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Veron, Vincent. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Mayence, Claire. Centre Hospitalier de l’Ouest Guyanais. Service d’accueil des urgences; Guayana Francesa
Fil: Demar Pierre, Magalie. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
Fil: Djossou, Félix. Centre Hospitalier Andrée Rosemon. Service de maladie infectieuse et tropicale; Guayana Francesa
Fil: Aznar, Christine. Centre Hospitalier Andrée Rosemon. Université des Antilles et de la Guyane. Laboratoire Hospitalier et Universitaire de Parasitologie et Mycologie Médicale; Guayana Francesa
description The outbreak of acute Chagas disease due to oral transmission of the parasite is a well-known phenomenon mainly occurring in the Amazon. Such an event is described here for the first time in French Guiana. Eight patients of the same family, presenting epidemiological and clinical histories compatible with recent Trypanosoma cruzi infection of Chagas disease due to the ingestion of palm Oenocarpus bacaba juice were, rather late after the putative date of infection, underwent four parasitological and two serological specific tests for confirmation of the diagnosis. Real-time PCR results were positive for all the patients; strains were isolated by hemoculture from four patients, PCR identification of TcI DTU was made for six patients, while parasites were not detected in any of the patients by direct microscopic examination. The results of two serologic tests were positive. All patients were treated with benznidazole, and two patients were additionally given nifurtimox. A 6-year follow-up was possible for six patients. Real-time PCR was negative for these patients after 1 year, while the antibody rates decreased slowly and serology results were negative only after several years (1–5 years). Our findings confirm the occurrence of an outbreak of Chagas infection in members of the same family, with the oral mode of infection being the most likely hypothesis to explain this group of cases. Our results show the successful treatment of patients infected by TcI and the usefulness of real-time PCR for the emergency diagnosis of recent Chagas disease cases and in posttreatment follow-up.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-14
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3945
Blanchet, Denis; Brenière, Simone Frédérique; Schijman, Alejandro Gabriel; Bisio, Margarita María Catalina; Simon, Stéphane; et al.; First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up; Elsevier; Infection, Genetics and Evolution; 28; 14-10-2014; 245-250
1567-1348
url http://hdl.handle.net/11336/3945
identifier_str_mv Blanchet, Denis; Brenière, Simone Frédérique; Schijman, Alejandro Gabriel; Bisio, Margarita María Catalina; Simon, Stéphane; et al.; First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up; Elsevier; Infection, Genetics and Evolution; 28; 14-10-2014; 245-250
1567-1348
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S156713481400375X
info:eu-repo/semantics/altIdentifier/issn/1567-1348
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2014.10.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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